Evaluation of Diuretic Activity of Siddha Poly Herbal Formulation <i>Vithu Vagai Chooranam</i> in Rodents

Q4 Pharmacology, Toxicology and Pharmaceutics Journal of Natural Remedies Pub Date : 2023-11-06 DOI:10.18311/jnr/2023/33995
I. Sundara Ganesh, R. S. Parvathy, Divya Jayachandran, P. Hrudayakumari, V. Shalini
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Abstract

The current pharmacological investigation was performed to study the diuretic activity of Siddha polyherbal formulation Vithu Vagai Chooranam (VVC) in Wistar albino rats using the Lipschitz method. The animals were divided into four Groups (I, II, III, and IV) of six rats (n = 6) each. Group I served as control treated with milk (1ml/kg p.o), and Group II received Standard furosemide (10 mg/kg, p.o). Groups III and Group IV were treated with test drug at a dose of 70mg/kg and 90mg/kg, p.o, respectively. The urine volume, pH, and electrolyte concentration (Na+, K+ and Cl-) were estimated at the end of 24 hours. Diuretic index, Lipschitz values, and natriuretic index were also calculated from the results to make a comparison with control and furosemide-treated groups. Statistical analysis was carried out using a one-way analysis of variance, followed by Dunnett’s ‘t’ test. Oral administration of VVC at both doses significantly increased the urine output and concentration of urinary electrolytes (p < 0.01). The VVC-induced diuresis pattern was almost like that of frusemide. The findings revealed that the Vithu vagai chooranam possessed significant diuretic activity in experimental rats.
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七陀多草药制剂的利尿活性评价[lt;i>;在啮齿动物
本实验采用Lipschitz方法,对西陀复方VVC (Vithu Vagai Chooranam)对Wistar白化大鼠的利尿作用进行药理学研究。动物分为四组(I、II、III、IV),每组6只,n = 6。ⅰ组作为对照,给予牛奶(1ml/kg p.o)处理,ⅱ组给予标准呋塞米(10mg /kg, p.o)处理。第三组和第四组分别给予试验药物70mg/kg和90mg/kg, p.o。在24小时结束时评估尿量、pH值和电解质浓度(Na+、K+和Cl-)。计算利尿指数、Lipschitz值和利钠指数,并与对照组和速尿组进行比较。统计分析采用单因素方差分析,然后进行Dunnett ' t检验。口服两种剂量的VVC可显著增加尿量和尿电解质浓度(p <0.01)。vc诱导的利尿模式与氟塞胺相似。结果表明,迷走草对实验大鼠具有明显的利尿作用。
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来源期刊
Journal of Natural Remedies
Journal of Natural Remedies Pharmacology, Toxicology and Pharmaceutics-Pharmacology
CiteScore
0.40
自引率
0.00%
发文量
27
期刊介绍: Nature can provide all the remedies, for all. All substances produced by nature can be recognized; all cells talk the same language as we all are from the same mother cell. Journal of Natural Remedies is devoted toward the understandings of all remedies from nature. Journal of Natural Remedies publishes original articles related to utilisation of any natural source for remedy including bioactive natural products. Studies related to the resources, chemistry (including analytical), biological activity, biotechnology and pharmacology (including toxicology) of archaea, bacteria, protistas, fungi, plants, animals, viruses and minerals fall within the journal’s scope.
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