P. Shrivastav, Suyog Yawale, Suraj Tichkule, S. Parwe
The present case report was a 25-year-old male patient with severe pain at the right index finger, fever, oedema, and discharge, not having any history of surgery, hypertension, diabetes, or any systemic disorder was diagnosed with kotha roga (necrotizing fasciitis). Presently available treatment for this is broad-spectrum intravenous antibiotics, appropriate hydration support, and meticulous surgical debridement with regular wound packing. But because of contaminated wounds and poor prognosis, herbal therapies have a possibility to cure kotha as they are readily available, and inexpensive. In this case, a kshara formulation i.e., modified ksharpichu was chosen as an atrial medication to be applied locally after everyday cleaning and dressing. It was observed that ksharpichu acted as a debriding agent and healing as well. The case was followed up for 30 days. This study employed pretty simple criteria to gain preliminary observations on the effectiveness of this Kshara taila on kotha roga.
{"title":"Management of Kotha Roga (Necrotizing Fasciitis) by Modified Ksharapichu (Wound Packing): A Case Report","authors":"P. Shrivastav, Suyog Yawale, Suraj Tichkule, S. Parwe","doi":"10.18311/jnr/2024/34920","DOIUrl":"https://doi.org/10.18311/jnr/2024/34920","url":null,"abstract":"The present case report was a 25-year-old male patient with severe pain at the right index finger, fever, oedema, and discharge, not having any history of surgery, hypertension, diabetes, or any systemic disorder was diagnosed with kotha roga (necrotizing fasciitis). Presently available treatment for this is broad-spectrum intravenous antibiotics, appropriate hydration support, and meticulous surgical debridement with regular wound packing. But because of contaminated wounds and poor prognosis, herbal therapies have a possibility to cure kotha as they are readily available, and inexpensive. In this case, a kshara formulation i.e., modified ksharpichu was chosen as an atrial medication to be applied locally after everyday cleaning and dressing. It was observed that ksharpichu acted as a debriding agent and healing as well. The case was followed up for 30 days. This study employed pretty simple criteria to gain preliminary observations on the effectiveness of this Kshara taila on kotha roga.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"19 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139818581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In this overview, information on the chemistry, sources, contents, and pharmacological properties of two flavones, namely, tricetin (TCT) and tricin (TC), is updated. TCT occurs mainly in honey and pollen of plant species belonging to the genus Eucalyptus of the family Myrtaceae. TC is found in monocotyledon species of the family Poaceae, occurring mainly in cereal crops such as oats, barley, rice, wheat, and corn, and in bamboo species. The chemical structure of TCT contains two hydroxyl (OH) groups at C5 and C7 of ring A and three OH groups at C3’, C4’, and C5’ of ring B, with no methoxy (OCH3) groups. TC has two OH groups at C5 and C7 of ring A, two OCH3 groups at C3’ and C5’, and one OH group at C4’ of ring B, i.e., at both sides of the C4’ OH group. This renders greater bioavailability, higher metabolic stability, and better intestinal absorption to TC than TCT. In this overview, TCT and TC have eight and seven studies on anti-cancer properties, and 14 and 31 studies on other pharmacological properties, respectively. Both flavones are equally strong in terms of cytotoxicity towards cancer cells. With greater bioavailability, higher metabolic stability, and better intestinal absorption, the other pharmacological properties of TC are stronger than TCT, but not for anti-cancer properties.
{"title":"Tricetin and Tricin: An Overview of the Chemistry, Sources, Contents, and Pharmacological Properties of these Flavones","authors":"Eric Wei Chiang Chan","doi":"10.18311/jnr/2024/33085","DOIUrl":"https://doi.org/10.18311/jnr/2024/33085","url":null,"abstract":"In this overview, information on the chemistry, sources, contents, and pharmacological properties of two flavones, namely, tricetin (TCT) and tricin (TC), is updated. TCT occurs mainly in honey and pollen of plant species belonging to the genus Eucalyptus of the family Myrtaceae. TC is found in monocotyledon species of the family Poaceae, occurring mainly in cereal crops such as oats, barley, rice, wheat, and corn, and in bamboo species. The chemical structure of TCT contains two hydroxyl (OH) groups at C5 and C7 of ring A and three OH groups at C3’, C4’, and C5’ of ring B, with no methoxy (OCH3) groups. TC has two OH groups at C5 and C7 of ring A, two OCH3 groups at C3’ and C5’, and one OH group at C4’ of ring B, i.e., at both sides of the C4’ OH group. This renders greater bioavailability, higher metabolic stability, and better intestinal absorption to TC than TCT. In this overview, TCT and TC have eight and seven studies on anti-cancer properties, and 14 and 31 studies on other pharmacological properties, respectively. Both flavones are equally strong in terms of cytotoxicity towards cancer cells. With greater bioavailability, higher metabolic stability, and better intestinal absorption, the other pharmacological properties of TC are stronger than TCT, but not for anti-cancer properties.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"39 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139821019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background Crocus sativus is popular herb used to improve and treat the memory, cognition related functions of brain and thereby impose significant role in improve and maintain brain health. The medicinal important part of Crocus sativus is stigma of flower which is rich in apocarotenoids crocin, picrocrocin, safranal and many more volatile compounds. The pharmacological actions such as antioxidant, anti-amyloidogenic, anti-depressant, anti depressant, anti cancer, anti inflammatory etc. properties are attributed due to of presence of caratenoids. However the poor stability, solubility and enzymatic degradation of bioactives of Crocus sativus have substantially limited their therapeutic application. In this study, a saffron nano emulsion of carotenoid rich fraction of Crocus sativus extract was assessed for its safety and efficacy. Methodology The single dose acute oral toxicity assessment of nanoemulsion was performed as per OECD 420 to determine the lethal dose (LD50). The subacute repeated 28 days oral toxicity was performed to provide the effective dose for the preclinical assessment as per OECD guideline 407 The animals were observed during the entire toxicity experimentation for any toxic signs and changes of hematological, biochemistry parameters. The efficacy study of saffron nano emulsion was evaluated by two behavioral test models- Passive avoidance test and Morris water maze test using scopolamine induced memory impairment. Results & Conclusions Animals administered 500 mg/kg/day as single dose orally did not cause any signs of toxicity or mortality in rats and results of acute toxicity assessment of saffron nano emulsion has indicated that the NOAEL (No Observed Adverse Effective Level) of saffron nano emulsion was found to be 500 mg/kg. In subacute toxicity study three different dose of 75, 100 & 125 mg/kg/day for 28 days administered orally in animals revealed no significant changes in body weight, hematological, biochemical parameters. The histopathological study has indicated no pathological changes observed in the vital organs of rats treated with the 125 mg/kg/day. The efficacy assessment of saffron nano emulsion using two behavioral models have suggested that nano emulsion at the dose of 10 mg/kg/day was significantly reduced the Scopolamine induced memory impairment.
{"title":"Preclinical Assessment of Crocus sativus Extract Loaded Nano Emulsion for Scopolamine Induced Cognitive Impairment: A Comprehensive Safety and Efficacy Study","authors":"Namrata Parikh, Komal Patel","doi":"10.18311/jnr/2024/34995","DOIUrl":"https://doi.org/10.18311/jnr/2024/34995","url":null,"abstract":"Background \u0000Crocus sativus is popular herb used to improve and treat the memory, cognition related functions of brain and thereby impose significant role in improve and maintain brain health. The medicinal important part of Crocus sativus is stigma of flower which is rich in apocarotenoids crocin, picrocrocin, safranal and many more volatile compounds. The pharmacological actions such as antioxidant, anti-amyloidogenic, anti-depressant, anti depressant, anti cancer, anti inflammatory etc. properties are attributed due to of presence of caratenoids. However the poor stability, solubility and enzymatic degradation of bioactives of Crocus sativus have substantially limited their therapeutic application. In this study, a saffron nano emulsion of carotenoid rich fraction of Crocus sativus extract was assessed for its safety and efficacy. \u0000Methodology \u0000The single dose acute oral toxicity assessment of nanoemulsion was performed as per OECD 420 to determine the lethal dose (LD50). The subacute repeated 28 days oral toxicity was performed to provide the effective dose for the preclinical assessment as per OECD guideline 407 The animals were observed during the entire toxicity experimentation for any toxic signs and changes of hematological, biochemistry parameters. The efficacy study of saffron nano emulsion was evaluated by two behavioral test models- Passive avoidance test and Morris water maze test using scopolamine induced memory impairment. \u0000Results & Conclusions \u0000Animals administered 500 mg/kg/day as single dose orally did not cause any signs of toxicity or mortality in rats and results of acute toxicity assessment of saffron nano emulsion has indicated that the NOAEL (No Observed Adverse Effective Level) of saffron nano emulsion was found to be 500 mg/kg. In subacute toxicity study three different dose of 75, 100 & 125 mg/kg/day for 28 days administered orally in animals revealed no significant changes in body weight, hematological, biochemical parameters. The histopathological study has indicated no pathological changes observed in the vital organs of rats treated with the 125 mg/kg/day. \u0000The efficacy assessment of saffron nano emulsion using two behavioral models have suggested that nano emulsion at the dose of 10 mg/kg/day was significantly reduced the Scopolamine induced memory impairment.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"205 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139821526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Stroke is one of the leading causes of adult neurological disability across the globe. Currently, Intracranial Haemorrhage (ICH) has the highest mortality rate of all stroke subtypes. An ICH accounts for only 15% of all stroke subtypes but is one of the most disabling forms of stroke. Over one-third of patients with ICH do not survive and only 20% regain functional independence. This high rate of morbidity and mortality has prompted investigations into new medical and alternative medical therapies for ICH. The stroke is defined in the context of pakshaghata as a vatavyadhi affecting the madhyama rogamarga in which the siras and snayus are affected. The patient was administered to Rookshana followed by oleation, fomentation, purification, enema, and nasal purgation along with selected samana drugs. Assessments were done before and after treatment using Medical Research Council (MRC) Scales, Modified Rankin Scale (mRS), and National Institutes of Health Stroke Scales (NIHSS). The assessments revealed a positive approach to external and internal Ayurvedic treatments as a supporting treatment for the management of stroke due to ICH. The gradual recovery was promising and worth documenting.
中风是导致全球成人神经残疾的主要原因之一。目前，在所有中风亚型中，颅内出血（ICH）的死亡率最高。ICH 仅占所有中风亚型的 15%，但却是致残率最高的中风形式之一。超过三分之一的 ICH 患者无法存活，只有 20% 的患者能恢复功能独立。如此高的发病率和死亡率促使人们研究治疗 ICH 的新医疗方法和替代疗法。中风在 pakshaghata 中被定义为影响 madhyama rogamarga 的 vatavyadhi，其中 siras 和 snayus 受到影响。在对患者进行 Rookshana 治疗后，还使用了发油、熏蒸、净化、灌肠和鼻腔净化等方法，并使用了选定的 Samana 药物。治疗前后使用医学研究委员会（MRC）量表、改良朗肯量表（mRS）和美国国立卫生研究院卒中量表（NIHSS）进行了评估。评估结果显示，患者积极采用内外阿育吠陀疗法作为治疗 ICH 引起的中风的辅助疗法。患者逐渐恢复的情况令人鼓舞，值得记录在案。
{"title":"Ayurveda as a Supportive Treatment: A Case Report on Integrative Management of Intracranial Haemorrhage","authors":"Preethy Bhasimon, Aswathy Mohan, Radhika Sourabh","doi":"10.18311/jnr/2024/33818","DOIUrl":"https://doi.org/10.18311/jnr/2024/33818","url":null,"abstract":"Stroke is one of the leading causes of adult neurological disability across the globe. Currently, Intracranial Haemorrhage (ICH) has the highest mortality rate of all stroke subtypes. An ICH accounts for only 15% of all stroke subtypes but is one of the most disabling forms of stroke. Over one-third of patients with ICH do not survive and only 20% regain functional independence. This high rate of morbidity and mortality has prompted investigations into new medical and alternative medical therapies for ICH. The stroke is defined in the context of pakshaghata as a vatavyadhi affecting the madhyama rogamarga in which the siras and snayus are affected. The patient was administered to Rookshana followed by oleation, fomentation, purification, enema, and nasal purgation along with selected samana drugs. Assessments were done before and after treatment using Medical Research Council (MRC) Scales, Modified Rankin Scale (mRS), and National Institutes of Health Stroke Scales (NIHSS). The assessments revealed a positive approach to external and internal Ayurvedic treatments as a supporting treatment for the management of stroke due to ICH. The gradual recovery was promising and worth documenting.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"63 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139873070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L. S. Kuchkarova, Khasan Yusuf Ogli Kayumov, N. Ergashev, Gulchekhra Telgenbaevna Kudeshovа
Aim: This work aims to investigate the effect of quercetin on the development of small intestine disaccharidase activity in the offspring intoxicated with lead acetate. Material and Methods: The experiments were carried out on white outbred rats. Rats were divided into control and three experimental groups. In the control and 3rd experimental group, rats were nursed by intact mothers. In the 1st and 2nd experimental groups, rats were nursed by mothers who replaced drinking water with a 0.2% lead acetate solution. All experimental groups of rats were orally treated with quercetin (20 mg/kg/24 h) from the 3rd to 20th days of postnatal life. Body weight, small intestine weight as well as the activities of intestinal maltase and lactase were determined on the 7th, 14th, and 21st days after birth. Results: In rats nursed by mothers who used a solution of lead acetate instead of drinking water а body weight and the small intestine mucosa weight decreased, but intestinal maltase and lactase activity increased. Treatment of lead-intoxicated growing rats with quercetin restored the body weight, small intestine mucosa weight, and development rate of maltase and lactase activity. Conclusion: The effect of quercetin on the activity of intestinal maltase and sucrase in growing rats nursed by lead acetate consumed mother is mediated through the restoration of intoxication damage since treatment of intact growing rats with quercetin in the same way and at the same time did not affect on the intestinal disaccharidases activity.
{"title":"Effect of Quercetin on the Intestinal Carbohydrases Activity in the Offspring of the Lead Intoxicated Mother","authors":"L. S. Kuchkarova, Khasan Yusuf Ogli Kayumov, N. Ergashev, Gulchekhra Telgenbaevna Kudeshovа","doi":"10.18311/jnr/2024/32682","DOIUrl":"https://doi.org/10.18311/jnr/2024/32682","url":null,"abstract":"Aim: This work aims to investigate the effect of quercetin on the development of small intestine disaccharidase activity in the offspring intoxicated with lead acetate.\u0000Material and Methods: The experiments were carried out on white outbred rats. Rats were divided into control and three experimental groups. In the control and 3rd experimental group, rats were nursed by intact mothers. In the 1st and 2nd experimental groups, rats were nursed by mothers who replaced drinking water with a 0.2% lead acetate solution. All experimental groups of rats were orally treated with quercetin (20 mg/kg/24 h) from the 3rd to 20th days of postnatal life. Body weight, small intestine weight as well as the activities of intestinal maltase and lactase were determined on the 7th, 14th, and 21st days after birth.\u0000Results: In rats nursed by mothers who used a solution of lead acetate instead of drinking water а body weight and the small intestine mucosa weight decreased, but intestinal maltase and lactase activity increased. Treatment of lead-intoxicated growing rats with quercetin restored the body weight, small intestine mucosa weight, and development rate of maltase and lactase activity.\u0000Conclusion: The effect of quercetin on the activity of intestinal maltase and sucrase in growing rats nursed by lead acetate consumed mother is mediated through the restoration of intoxication damage since treatment of intact growing rats with quercetin in the same way and at the same time did not affect on the intestinal disaccharidases activity.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"20 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139882455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background Crocus sativus is popular herb used to improve and treat the memory, cognition related functions of brain and thereby impose significant role in improve and maintain brain health. The medicinal important part of Crocus sativus is stigma of flower which is rich in apocarotenoids crocin, picrocrocin, safranal and many more volatile compounds. The pharmacological actions such as antioxidant, anti-amyloidogenic, anti-depressant, anti depressant, anti cancer, anti inflammatory etc. properties are attributed due to of presence of caratenoids. However the poor stability, solubility and enzymatic degradation of bioactives of Crocus sativus have substantially limited their therapeutic application. In this study, a saffron nano emulsion of carotenoid rich fraction of Crocus sativus extract was assessed for its safety and efficacy. Methodology The single dose acute oral toxicity assessment of nanoemulsion was performed as per OECD 420 to determine the lethal dose (LD50). The subacute repeated 28 days oral toxicity was performed to provide the effective dose for the preclinical assessment as per OECD guideline 407 The animals were observed during the entire toxicity experimentation for any toxic signs and changes of hematological, biochemistry parameters. The efficacy study of saffron nano emulsion was evaluated by two behavioral test models- Passive avoidance test and Morris water maze test using scopolamine induced memory impairment. Results & Conclusions Animals administered 500 mg/kg/day as single dose orally did not cause any signs of toxicity or mortality in rats and results of acute toxicity assessment of saffron nano emulsion has indicated that the NOAEL (No Observed Adverse Effective Level) of saffron nano emulsion was found to be 500 mg/kg. In subacute toxicity study three different dose of 75, 100 & 125 mg/kg/day for 28 days administered orally in animals revealed no significant changes in body weight, hematological, biochemical parameters. The histopathological study has indicated no pathological changes observed in the vital organs of rats treated with the 125 mg/kg/day. The efficacy assessment of saffron nano emulsion using two behavioral models have suggested that nano emulsion at the dose of 10 mg/kg/day was significantly reduced the Scopolamine induced memory impairment.
{"title":"Preclinical Assessment of Crocus sativus Extract Loaded Nano Emulsion for Scopolamine Induced Cognitive Impairment: A Comprehensive Safety and Efficacy Study","authors":"Namrata Parikh, Komal Patel","doi":"10.18311/jnr/2024/34995","DOIUrl":"https://doi.org/10.18311/jnr/2024/34995","url":null,"abstract":"Background \u0000Crocus sativus is popular herb used to improve and treat the memory, cognition related functions of brain and thereby impose significant role in improve and maintain brain health. The medicinal important part of Crocus sativus is stigma of flower which is rich in apocarotenoids crocin, picrocrocin, safranal and many more volatile compounds. The pharmacological actions such as antioxidant, anti-amyloidogenic, anti-depressant, anti depressant, anti cancer, anti inflammatory etc. properties are attributed due to of presence of caratenoids. However the poor stability, solubility and enzymatic degradation of bioactives of Crocus sativus have substantially limited their therapeutic application. In this study, a saffron nano emulsion of carotenoid rich fraction of Crocus sativus extract was assessed for its safety and efficacy. \u0000Methodology \u0000The single dose acute oral toxicity assessment of nanoemulsion was performed as per OECD 420 to determine the lethal dose (LD50). The subacute repeated 28 days oral toxicity was performed to provide the effective dose for the preclinical assessment as per OECD guideline 407 The animals were observed during the entire toxicity experimentation for any toxic signs and changes of hematological, biochemistry parameters. The efficacy study of saffron nano emulsion was evaluated by two behavioral test models- Passive avoidance test and Morris water maze test using scopolamine induced memory impairment. \u0000Results & Conclusions \u0000Animals administered 500 mg/kg/day as single dose orally did not cause any signs of toxicity or mortality in rats and results of acute toxicity assessment of saffron nano emulsion has indicated that the NOAEL (No Observed Adverse Effective Level) of saffron nano emulsion was found to be 500 mg/kg. In subacute toxicity study three different dose of 75, 100 & 125 mg/kg/day for 28 days administered orally in animals revealed no significant changes in body weight, hematological, biochemical parameters. The histopathological study has indicated no pathological changes observed in the vital organs of rats treated with the 125 mg/kg/day. \u0000The efficacy assessment of saffron nano emulsion using two behavioral models have suggested that nano emulsion at the dose of 10 mg/kg/day was significantly reduced the Scopolamine induced memory impairment.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"18 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139881132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kombucha is a traditional carbonated tea obtained by fermentation with Symbiotic Culture of Bacteria and Yeast(SCOBY). The SCOBY consumes sugar in tea and produces enzymes and organic acids. The process typically takes one or two weeks and changes tea into a fizzy, slightly sour fermented (generally non-alcoholic) beverage. Kombucha contains chemical and biologically active compounds such as polyphenols, antioxidants, and a source of probiotics (Lactobacillus) that show health-promoting properties. Kombucha has potential health benefits, but not all have been proven in studies with humans. It is being commercialized in India and can be prepared at home easily with precautions. It can be prepared by fermenting sweetened green or black tea using a Symbiotic Culture of Bacteria and Yeast (SCOBY). As the fermentation proceeds, the yeast in the SCOBY breaks down the sugar present in the tea and releases friendly probiotic bacteria. In this paper, we highlighted various factors affecting fermentation, where the pH shows a significant impact on the tea quality. Herein, we have also discussed the health benefits and toxicity of Kombucha tea along with the recent literature.
{"title":"Natural Carbonated Drink (Kombucha Tea) and its Health Benefits: A Review","authors":"Kalpana Gupta, Yogita Malhotra, Priyanka Choudhary","doi":"10.18311/jnr/2024/34587","DOIUrl":"https://doi.org/10.18311/jnr/2024/34587","url":null,"abstract":"Kombucha is a traditional carbonated tea obtained by fermentation with Symbiotic Culture of Bacteria and Yeast(SCOBY). The SCOBY consumes sugar in tea and produces enzymes and organic acids. The process typically takes one or two weeks and changes tea into a fizzy, slightly sour fermented (generally non-alcoholic) beverage. Kombucha contains chemical and biologically active compounds such as polyphenols, antioxidants, and a source of probiotics (Lactobacillus) that show health-promoting properties. Kombucha has potential health benefits, but not all have been proven in studies with humans. It is being commercialized in India and can be prepared at home easily with precautions. It can be prepared by fermenting sweetened green or black tea using a Symbiotic Culture of Bacteria and Yeast (SCOBY). As the fermentation proceeds, the yeast in the SCOBY breaks down the sugar present in the tea and releases friendly probiotic bacteria. In this paper, we highlighted various factors affecting fermentation, where the pH shows a significant impact on the tea quality. Herein, we have also discussed the health benefits and toxicity of Kombucha tea along with the recent literature.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"81 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139884782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Surya Prabha Matangi, R. Samineni, Kanhaiya Kumar, Ashutosh Kumar, Shantanu Kumar, M. Salmon Raju
Different plant components have been used in medicinal preparations in indigenous systems of medicine to clean teeth or treat oral diseases such as periodontal disease. Herbal toothpaste is equally as good at controlling plaque and gingivitis as dentifrices made according to standard formulas. Streptococcus mutants, out of all the examined bacteria, were shown towards the most susceptible to the created dentifrice, as evidenced by a zone inhibition (7-8 mm), followed by Escherichia coli (7 mm), as well as oral micro-biota (8mm). The created Poly-herbal dentifrice was successfully tested using a variety of industry-recognized standards to verify its high quality and physio-chemical qualities. According to the findings, the created Poly-herbal dentifrice shows promise for having antibacterial properties on both gramme-positive and gramme-negative organisms. Compared to completely synthetic dentifrice, it must be safer. For the development of Poly-herbal dentifrice to be proven safe and effective, more research is required. According to the study’s findings, herbal toothpaste is safer and has fewer side effects than synthetic preparations. It is also more commonly used in dentistry research. The toothpaste that is designed for oral hygiene and teeth shows antimicrobial activity against pathogens. The market preparation was contrasted with the formulation. Therefore, it demonstrates an equal amount of patronizing and engrossing passion for the promoted formulations. The development of herbal toothpaste has a promising future in the research of natural cures and general dental health.
{"title":"Plants as Regular Phytochemical Sources of Dentistry - Formulation and Evaluation of Polyherbal Tooth Paste","authors":"Surya Prabha Matangi, R. Samineni, Kanhaiya Kumar, Ashutosh Kumar, Shantanu Kumar, M. Salmon Raju","doi":"10.18311/jnr/2024/34575","DOIUrl":"https://doi.org/10.18311/jnr/2024/34575","url":null,"abstract":"Different plant components have been used in medicinal preparations in indigenous systems of medicine to clean teeth or treat oral diseases such as periodontal disease. Herbal toothpaste is equally as good at controlling plaque and gingivitis as dentifrices made according to standard formulas. Streptococcus mutants, out of all the examined bacteria, were shown towards the most susceptible to the created dentifrice, as evidenced by a zone inhibition (7-8 mm), followed by Escherichia coli (7 mm), as well as oral micro-biota (8mm). The created Poly-herbal dentifrice was successfully tested using a variety of industry-recognized standards to verify its high quality and physio-chemical qualities. According to the findings, the created Poly-herbal dentifrice shows promise for having antibacterial properties on both gramme-positive and gramme-negative organisms. Compared to completely synthetic dentifrice, it must be safer. For the development of Poly-herbal dentifrice to be proven safe and effective, more research is required. According to the study’s findings, herbal toothpaste is safer and has fewer side effects than synthetic preparations. It is also more commonly used in dentistry research. The toothpaste that is designed for oral hygiene and teeth shows antimicrobial activity against pathogens. The market preparation was contrasted with the formulation. Therefore, it demonstrates an equal amount of patronizing and engrossing passion for the promoted formulations. The development of herbal toothpaste has a promising future in the research of natural cures and general dental health.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"29 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139885839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Greeshma, R. Thamizselvi, S. Muthulingam, Sam John, Dhanya B. Sen
Nowadays, most antiviral drugs are plant-based due to their low toxicity and high resistance. Morinda citrifolia (Noni) is such a perennial shrub a popular plant based medicine due to its wide therapeutic applications. The phytochemicals present in its fruit as well as its leaf have many antiviral properties and can enhance the human immune system. Herein, we report the identification of bioactive components present in the Morinda citrifolia (Noni) ethanolic leaf extract by GC-MS analysis and their biological interaction with human parallel-stranded 7-mer g-quadruplex DNA of MCF-7 using Biovia Discovery Studio software. In vitro analysis by MTT assay of the same extract reported a living cells of 59.74% at 100 µg/ml. The GC-MS analysis of ethanolic leaf extract revealed the presence of 27 bioactive components, and out of these, six major components were interacted with cancer DNA. The molecular docking interaction identified the most active bio component Phytol, with a binding energy of -27.0796 Kcal/mol. this value is much better than the commercially available doxorubicin. This novel study will provide insight into the development of bioactive components from Morinda citrifolia leaf extract against human breast cancer with minimal side effects.
如今，大多数抗病毒药物都以植物为基础，因为它们毒性低、抗药性强。诺丽果（Morinda citrifolia）就是这样一种多年生灌木，因其广泛的治疗用途而成为一种流行的植物性药物。其果实和叶片中的植物化学物质具有多种抗病毒特性，并能增强人体免疫系统。在此，我们利用 Biovia Discovery Studio 软件，通过气相色谱-质谱（GC-MS）分析鉴定了海巴戟（诺丽）乙醇叶提取物中的生物活性成分，以及它们与 MCF-7 的人体平行链 7-mer g-quadruplex DNA 的生物相互作用。用 MTT 法对同一提取物进行体外分析，结果表明在 100 µg/ml 的浓度下，活细胞率为 59.74%。乙醇叶提取物的气相色谱-质谱（GC-MS）分析表明，其中含有 27 种生物活性成分，其中六种主要成分与癌症 DNA 有相互作用。分子对接相互作用确定了最具活性的生物成分植物醇，其结合能为 -27.0796 Kcal/mol。这项新颖的研究将为开发海巴戟叶提取物中的生物活性成分提供深入的见解，从而在最小的副作用下对抗人类乳腺癌。
{"title":"A Study on Biologically Active Components in Morinda citrifolia Leaf Extract and its Anti-cancer Effect by In Vitro Analysis and In Silico Molecular Docking Method","authors":"K. Greeshma, R. Thamizselvi, S. Muthulingam, Sam John, Dhanya B. Sen","doi":"10.18311/jnr/2024/33868","DOIUrl":"https://doi.org/10.18311/jnr/2024/33868","url":null,"abstract":"Nowadays, most antiviral drugs are plant-based due to their low toxicity and high resistance. Morinda citrifolia (Noni) is such a perennial shrub a popular plant based medicine due to its wide therapeutic applications. The phytochemicals present in its fruit as well as its leaf have many antiviral properties and can enhance the human immune system. Herein, we report the identification of bioactive components present in the Morinda citrifolia (Noni) ethanolic leaf extract by GC-MS analysis and their biological interaction with human parallel-stranded 7-mer g-quadruplex DNA of MCF-7 using Biovia Discovery Studio software. In vitro analysis by MTT assay of the same extract reported a living cells of 59.74% at 100 µg/ml. The GC-MS analysis of ethanolic leaf extract revealed the presence of 27 bioactive components, and out of these, six major components were interacted with cancer DNA. The molecular docking interaction identified the most active bio component Phytol, with a binding energy of -27.0796 Kcal/mol. this value is much better than the commercially available doxorubicin. This novel study will provide insight into the development of bioactive components from Morinda citrifolia leaf extract against human breast cancer with minimal side effects.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"27 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139872351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Purpose: The purpose of the research work was the extraction and isolation of Ursolic Acid (URA) from the leaves of Nerium oleander (N. oleander) and the assessment of its anti-inflammatory activity using an in-vitro model. Methods: Ursolic Acid (URA) is a bioactive molecule. It is a key component of N. oleander. The hydroalcoholic maceration method was used for extract preparation and was used to isolate the bioactive components of URA. The prepared extract, isolated URA were characterize and analyse by using pharmacognostic parameters, Fourier Transform Infrared (FTIR) and Thin Layer Chromatography (TLC) method. The carrageenan-induced inflammation rat paw oedema test in-vitro model was used for the assessment of anti-inflammatory properties of isolated bioactive compound URA. Results: The results of evaluation and characterization indicated that the extract’s ash value and extractive values were within the parameters specified in the Indian Ayurvedic Pharmacopoeia. The prepared hydroalcohalic extract has potential bioactive components such as flavonoids, saponins, and triterpinoids. The isolated compound was URA. The extract may be able to alleviate inflammation, according to the percentage inhibition. Conclusion: The URA was successfully removed from the leaves of N. oleander. The examination criteria revealed that the extract contained certain small contaminants, which may have anti-inflammatory effects.
目的：研究工作的目的是从夹竹桃叶中提取和分离熊果酸（URA），并利用体外模型评估其抗炎活性：方法：熊果酸（URA）是一种生物活性分子。方法：熊果酸（URA）是一种生物活性分子，是夹竹桃的主要成分。采用水醇浸泡法制备提取物，并分离出 URA 的生物活性成分。利用药理学参数、傅立叶变换红外光谱（FTIR）和薄层色谱法（TLC）对制备的提取物和分离的 URA 进行了表征和分析。使用卡拉胶诱导的炎症大鼠爪水肿体外模型来评估分离的生物活性化合物 URA 的抗炎特性：评估和表征结果表明，提取物的灰分值和萃取值均符合印度阿育吠陀药典规定的参数。所制备的水合提取物具有潜在的生物活性成分，如类黄酮、皂苷和三萜类化合物。分离出的化合物是 URA。根据抑制百分比，该提取物可以缓解炎症。结论成功地从夹竹桃叶中提取了 URA。检查标准显示，提取物中含有某些可能具有抗炎作用的小杂质。
{"title":"Isolation, Formulation and Assessment of Anti-inflammatory Properties of Ursolic Acid from Nerium oleander","authors":"Ajay Kumar Shukla, Manish Kumar Yadav, Komal Sharma","doi":"10.18311/jnr/2024/33540","DOIUrl":"https://doi.org/10.18311/jnr/2024/33540","url":null,"abstract":"Purpose: The purpose of the research work was the extraction and isolation of Ursolic Acid (URA) from the leaves of Nerium oleander (N. oleander) and the assessment of its anti-inflammatory activity using an in-vitro model.\u0000Methods: Ursolic Acid (URA) is a bioactive molecule. It is a key component of N. oleander. The hydroalcoholic maceration method was used for extract preparation and was used to isolate the bioactive components of URA. The prepared extract, isolated URA were characterize and analyse by using pharmacognostic parameters, Fourier Transform Infrared (FTIR) and Thin Layer Chromatography (TLC) method. The carrageenan-induced inflammation rat paw oedema test in-vitro model was used for the assessment of anti-inflammatory properties of isolated bioactive compound URA.\u0000Results: The results of evaluation and characterization indicated that the extract’s ash value and extractive values were within the parameters specified in the Indian Ayurvedic Pharmacopoeia. The prepared hydroalcohalic extract has potential bioactive components such as flavonoids, saponins, and triterpinoids. The isolated compound was URA. The extract may be able to alleviate inflammation, according to the percentage inhibition. Conclusion: The URA was successfully removed from the leaves of N. oleander. The examination criteria revealed that the extract contained certain small contaminants, which may have anti-inflammatory effects.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"171 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139824982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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