Evaluation of ameliorative potential of antioxidants and/or immunomodulators in contagious caprine pleuropneumonia affected Himalayan Pashmina goats

IF 0.2 4区 农林科学 Q4 AGRICULTURE, DAIRY & ANIMAL SCIENCE Indian Journal of Animal Sciences Pub Date : 2023-09-13 DOI:10.56093/ijans.v93i9.110402
OVEAS RAFFIQ PARRAY, None MUHEET, RIYAZ AHMAD BHAT, HAMID ULLAH MALIK, SABIA QURESHI, SHAFAYAT AHMAD BEIG, QURAT UL AIN NAZIR, MAJID SHAFI KAWOOSA, IZHAR AHMAD RATHER, AMATUL MUHEE, TAWHEED SHAFI, MOHD IQBAL YATOO
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Abstract

Contagious caprine pleuropneumonia causes oxidative stress and immune disturbances in affected goats. Hence these derogative alterations aggravate the pathogenesis and severity of this disease, thus, necessitating utilization of antioxidants and/or immunomodulators in the therapeutic regimes of contagious caprine pleuropneumonia. Present study evaluated ameliorative effects of N-acetyl cysteine (NAC) and alpha tocopherol (vitamin E) in association with primary antibiotic tylosin treatment in contagious caprine pleuropneumonia affected test goats in comparison to antibiotic only treated goats (n=6) and healthy goats (n=6). N-acetyl cysteine given at a dose of 12 mg per kg of body weight orally daily for 7 days, showed better antioxidant effect by significantly ameliorating oxidative stress (41.4%) compared to other treatments; besides, decreasing total oxidative status (TOS) and increasing total antioxidant status (TAS). Immunomodulatory potential of alpha tocopherol given at a dose of 10 mg per kg of body weight orally daily for 7 days, was found to be comparatively better than NAC in decreasing percentage of neutrophils and increasing percentage of lymphocytes; besides, decreasing the levels of tumor necrosis factor-α (TNF-α) and immunoglobulin G (IgG) when the modulation of total leukocyte count and differential leukocyte count was comparable between the two. Thus, it can be concluded from this study that NAC acts as a comparatively better antioxidant and alpha tocopherol as better immunomodulator when used in the therapeutic regimes of contagious caprine pleuropneumonia.
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抗氧化剂和/或免疫调节剂对喜马拉雅帕什米娜山羊传染性胸膜肺炎的改善潜力的评价
传染性山羊胸膜肺炎引起受感染山羊的氧化应激和免疫紊乱。因此,这些有害的改变加重了这种疾病的发病机制和严重程度,因此,有必要在传染性羊胸膜肺炎的治疗方案中使用抗氧化剂和/或免疫调节剂。本研究评估了n -乙酰半胱氨酸(NAC)和α -生育酚(维生素E)与初级抗生素泰络素治疗对传染性山羊胸膜肺炎感染试验山羊的改善作用,并将其与仅抗生素治疗的山羊(n=6)和健康山羊(n=6)进行了比较。n -乙酰半胱氨酸(N-acetyl半胱氨酸)每公斤体重12 mg,每天口服7天,与其他治疗相比,显示出更好的抗氧化作用,显著改善氧化应激(41.4%);总氧化状态(TOS)降低,总抗氧化状态(TAS)升高。研究发现,α -生育酚在降低中性粒细胞百分比和增加淋巴细胞百分比方面优于NAC,每日口服剂量为每公斤体重10 mg,连续7天;此外,总白细胞计数和差异白细胞计数的调节对肿瘤坏死因子-α (TNF-α)和免疫球蛋白G (IgG)水平的降低具有可比性。因此,本研究可以得出结论,NAC作为相对较好的抗氧化剂,α -生育酚作为较好的免疫调节剂用于传染性羊胸膜肺炎的治疗方案。
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来源期刊
Indian Journal of Animal Sciences
Indian Journal of Animal Sciences 农林科学-奶制品与动物科学
CiteScore
0.60
自引率
25.00%
发文量
220
审稿时长
8 months
期刊介绍: Articles published in The Indian Journal of Animal Sciences encompass a broad range of research topics in animal health and production related to cattle, buffalo, sheep, goat, camel, equines, pig, rabbit, yak, mithun, poultry and fisheries. Studies involving wildlife species and laboratory animal species that address fundamental questions about their biology will also be considered for publication. All manuscripts must present some new development and must be original, timely, significant and scientifically excellent. Papers will be rejected if standards of care of, or procedures performed on animals are not up to those expected of humane veterinary scientists. At a minimum, standards must meet the International Guiding Principles for Biomedical Research involving Animals, as issued by the Council for International Organizations of Medical Sciences. (C.I.O.M.S., c/o WHO, CH 1211 Geneva 27, Switzerland). Articles reporting new animal disease must follow GOI directive as given in detail in Guidelines to Authors.
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