Exploring the impact of mulberry fruits on metabolic syndrome: A systematic review of current evidence

IF 2.4 Q3 NUTRITION & DIETETICS PharmaNutrition Pub Date : 2023-11-14 DOI:10.1016/j.phanu.2023.100363
Matilde Tornaghi , Ali Ali Redha , Mariangela Rondanelli , Simone Perna
{"title":"Exploring the impact of mulberry fruits on metabolic syndrome: A systematic review of current evidence","authors":"Matilde Tornaghi ,&nbsp;Ali Ali Redha ,&nbsp;Mariangela Rondanelli ,&nbsp;Simone Perna","doi":"10.1016/j.phanu.2023.100363","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>Mulberries are rich in nutrients including a wide range of polyphenols that possess different bioactive properties. This systematic review illustrates mulberry's potential as a promising plant food for mitigating the perturbations associated with metabolic syndrome.</p></div><div><h3>Methods</h3><p>A systematic search was conducted on 1st March 2023 in Scopus and PubMed. A total of 15 eligible studies (in vitro and in vivo<em>)</em> studies evaluating the effect of mulberries on metabolic syndrome-related factors such as obesity, diabetes, high cholesterol and high blood pressure were included.</p></div><div><h3>Results</h3><p>Predominantly, the studies have centred around its anti-visceral-obesity and lipid-reducing effects. The interventions in these studies spanned 8–12 weeks, employing modest oral doses—ranging from 10 to 800 of mg/kg of body weight per day—of mulberry extracts, powders, or freeze-dried fruits. The favorable effects of mulberry are predominantly ascribed to its rich polyphenolic content, which interacts with diverse metabolic pathways. In terms of its anti-visceral-obesity effect, these polyphenolic compounds, particularly anthocyanins, exhibit the capacity to modulate fatty acid and triglyceride synthesis, enhance mitochondrial function, and attenuate reactive oxygen species accumulation. In vivo, constituents such as resveratrol, rutin, and anthocyanins demonstrate efficacy in inhibiting lipid synthesis, accumulation, and oxidation, leveraging their free radical scavenging ability, while concurrently orchestrating metabolic modulation in tandem with prebiotic agents.</p></div><div><h3>Conclusions</h3><p>Based on these data, it can be inferred that the utilization of white mulberry holds greater promise in the management of ailments like hypertension and dyslipidemia. Conversely, black mulberry displays efficacy in addressing diabetes and obesity.</p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":"26 ","pages":"Article 100363"},"PeriodicalIF":2.4000,"publicationDate":"2023-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S221343442300035X/pdfft?md5=b9203f7984fc633eeaa3c077971b7171&pid=1-s2.0-S221343442300035X-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"PharmaNutrition","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S221343442300035X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}
引用次数: 0

Abstract

Background

Mulberries are rich in nutrients including a wide range of polyphenols that possess different bioactive properties. This systematic review illustrates mulberry's potential as a promising plant food for mitigating the perturbations associated with metabolic syndrome.

Methods

A systematic search was conducted on 1st March 2023 in Scopus and PubMed. A total of 15 eligible studies (in vitro and in vivo) studies evaluating the effect of mulberries on metabolic syndrome-related factors such as obesity, diabetes, high cholesterol and high blood pressure were included.

Results

Predominantly, the studies have centred around its anti-visceral-obesity and lipid-reducing effects. The interventions in these studies spanned 8–12 weeks, employing modest oral doses—ranging from 10 to 800 of mg/kg of body weight per day—of mulberry extracts, powders, or freeze-dried fruits. The favorable effects of mulberry are predominantly ascribed to its rich polyphenolic content, which interacts with diverse metabolic pathways. In terms of its anti-visceral-obesity effect, these polyphenolic compounds, particularly anthocyanins, exhibit the capacity to modulate fatty acid and triglyceride synthesis, enhance mitochondrial function, and attenuate reactive oxygen species accumulation. In vivo, constituents such as resveratrol, rutin, and anthocyanins demonstrate efficacy in inhibiting lipid synthesis, accumulation, and oxidation, leveraging their free radical scavenging ability, while concurrently orchestrating metabolic modulation in tandem with prebiotic agents.

Conclusions

Based on these data, it can be inferred that the utilization of white mulberry holds greater promise in the management of ailments like hypertension and dyslipidemia. Conversely, black mulberry displays efficacy in addressing diabetes and obesity.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
探索桑葚果实对代谢综合征的影响:对现有证据的系统回顾
桑葚含有丰富的营养物质,包括多种具有不同生物活性的多酚。这篇系统的综述说明了桑树作为一种有前途的植物性食物的潜力,可以减轻与代谢综合征相关的扰动。系统检索于2023年3月1日在Scopus和PubMed中进行。共纳入15项符合条件的研究(体外和体内),评估桑葚对代谢综合征相关因素(如肥胖、糖尿病、高胆固醇和高血压)的影响。这些研究主要集中在其抗内脏肥胖和降脂作用上。这些研究的干预措施持续了8-12周,采用适度的口服剂量——每天10 - 800毫克/千克体重的桑树提取物、粉末或冻干水果。桑树的有益作用主要归因于其丰富的多酚含量,多酚与多种代谢途径相互作用。就其抗内脏肥胖作用而言,这些多酚类化合物,特别是花青素,具有调节脂肪酸和甘油三酯合成、增强线粒体功能和减弱活性氧积累的能力。在体内,白藜芦醇、芦丁和花青素等成分显示出抑制脂质合成、积累和氧化的功效,利用它们的自由基清除能力,同时与益生元制剂协同协调代谢调节。基于这些数据,可以推断,白桑葚的利用在高血压和血脂异常等疾病的管理中具有更大的希望。相反,黑桑在治疗糖尿病和肥胖方面显示出功效。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
PharmaNutrition
PharmaNutrition Agricultural and Biological Sciences-Food Science
CiteScore
5.70
自引率
3.10%
发文量
33
审稿时长
12 days
期刊最新文献
A therapeutic approach to identify leading molecules from natural products and therapeutic targets in CKD by network pharmacology Efficacy and safety of crocin supplementation in patients with central serous chorioretinopathy, a pilot randomized double blinded clinical trial Dietitians’ knowledge and practice regarding inflammaging and related interventions: A pilot survey Exploring the molecular mechanisms and therapeutic benefits of L-theanine in counteracting inflammation Enhanced absorption of omega-3 fatty acids from a novel krill oil-derived phospholipid formulation compared to fish oil ethyl esters: A randomized, two-way crossover pharmacokinetic study
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1