PharmaNutrition最新文献

Milk fat globule membrane: Production, digestion, and health benefits evaluated through in vitro models 牛奶脂肪球膜：通过体外模型评估生产、消化和健康益处

IF 2.4 Q3 NUTRITION & DIETETICS

PharmaNutrition

Pub Date : 2024-10-31 DOI: 10.1016/j.phanu.2024.100418

Background

Milk is a biologically complex fluid with a primary function as a bioactive compound and energy source for the offspring in the early stages of life. This role is largely due to its high lipid content, encapsulated in globules known as milk fat globules (MFG). Extensive research has led to the conclusion that MFGs are not only energy carriers, as they are surrounded by a milk fat globule membrane (MFGM) which is characterized by its complex architecture and bioactive components such as polar lipids and glycoproteins.

Methods

This literature review was performed by an extensive search of Pubmed, Scopus or Google Scholar database for studies using keywords such as “lactation”, “milk production”, “MFG”, “MFGM”, “polar lipids”, “in vitro”, “milk lipids”, “health benefits”, “human health”, “digestion”, “bioaccessibility”, “bioavailability”.

Results

Brain and intestinal development, modulation of the microbiota or the correct immunological response to infections are some of the benefits that MFGM has in infants. In addition, its therapeutic potential is extended to the adult population through the attenuation of lipid metabolism disorders or the prevention of neurodegenerative diseases. Consequently, the trend in the food industry is to incorporate this MFGM concentrate as a bioactive ingredient in functional foods.

Conclusion

This review provides an overview of the natural and industrial production of MFGM and their relationship to the health benefits identified in in vitro studies. Furthermore, this review highlights the importance of further research to understand the assimilation of MFGM lipids to optimize its incorporation into the human diet.

背景牛奶是一种具有生物活性的复杂液体，其主要功能是作为生物活性化合物和生命早期阶段后代的能量来源。这种作用主要是由于牛奶中含有大量脂质，这些脂质包裹在被称为乳脂球（MFG）的球状物中。大量研究得出的结论是，乳脂球不仅是能量载体，还被乳脂球膜（MFGM）所包围，而乳脂球膜的特点是结构复杂，并含有极性脂质和糖蛋白等生物活性成分。方法通过在 Pubmed、Scopus 或 Google Scholar 数据库中使用 "泌乳"、"牛奶生产"、"MFG"、"MFGM"、"极性脂质"、"体外"、"牛奶脂质"、"健康益处"、"人类健康"、"消化"、"生物可及性"、"生物利用度 "等关键词广泛搜索相关研究，进行本文献综述。结果婴儿脑部和肠道发育、微生物群调节或对感染的正确免疫反应是牛奶中脂质对婴儿的一些益处。此外，通过减轻脂质代谢紊乱或预防神经退行性疾病，其治疗潜力也扩展到了成年人群。因此，食品行业的趋势是将这种 MFGM 浓缩物作为一种生物活性成分纳入功能性食品中。结论本综述概述了天然和工业生产的 MFGM 及其与体外研究发现的健康益处之间的关系。此外，本综述还强调了进一步研究了解 MFGM 脂类同化的重要性，以优化其在人类饮食中的应用。

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引用次数: 0

Advancements in psoriasis management: Integrating nutrient supplement with gut-brain-skin connection 牛皮癣治疗的进展：将营养补充剂与肠道-大脑-皮肤的联系结合起来

IF 2.4 Q3 NUTRITION & DIETETICS

PharmaNutrition

Pub Date : 2024-10-24 DOI: 10.1016/j.phanu.2024.100416

Background

Psoriasis is a chronic inflammatory skin disease that affects a large population globally and poses a significant challenge in clinical care due to its multifaceted characteristics. Recent studies show the relationship between the gut, brain, and skin, unveiling the potential for novel therapeutic approaches.

Methods

This review includes papers published from 1991 to 2024 exploring various advancements in psoriasis management. We also explored various techniques to encapsulate natural bioactive molecules with anti-psoriatic activity. The published articles were searched using various databases, including Scopus, Web of Science, Clinical Trials, and Google Scholar.

Results

The gut microbiome contains numerous microorganisms that influence immune regulation and inflammation. The pathogenesis of psoriasis has implicated an imbalance in gut microbes, known as gut dysbiosis. Probiotics, prebiotics, and other dietary interventions can help restore microbial balance and improve psoriasis symptoms. Furthermore, the gut microbiota can modulate neurotransmitters and neuropeptides, impacting communication between the gut, brain, and skin. Stress, a well-established trigger for psoriasis exacerbations, disrupts the gut-brain-skin axis. Nutrient supplements like omega-3 fatty acids, polyphenols, probiotic supplements, herbal supplements, etc. can reduce inflammation and enhance skin health. Deficiency in nutrients like vitamin D may contribute to psoriasis development. Targeting inflammatory pathways, balancing gut microbiomes, and addressing nutritional deficiencies can improve psoriasis treatment outcomes.

Conclusion

Natural bioactives have demonstrated antipsoriatic efficacy in several preclinical and clinical studies done in more recent years. Large-scale clinical trials using encapsulated natural bioactives are still needed to demonstrate their antipsoriatic activity and ability to regulate the gut-brain-skin axis.

背景银屑病是一种慢性炎症性皮肤病，影响着全球众多人群，由于其多方面的特点，给临床治疗带来了巨大挑战。最近的研究显示了肠道、大脑和皮肤之间的关系，揭示了新型治疗方法的潜力。方法本综述收录了 1991 年至 2024 年发表的论文，探讨了银屑病治疗的各种进展。我们还探讨了封装具有抗银屑病活性的天然生物活性分子的各种技术。我们使用 Scopus、Web of Science、Clinical Trials 和 Google Scholar 等多个数据库对已发表的文章进行了检索。银屑病的发病机制与肠道微生物失衡有关，即肠道菌群失调。益生菌、益生元和其他饮食干预措施有助于恢复微生物平衡，改善银屑病症状。此外，肠道微生物群还能调节神经递质和神经肽，影响肠道、大脑和皮肤之间的交流。压力是牛皮癣加重的公认诱因，会破坏肠道-大脑-皮肤轴。欧米伽-3 脂肪酸、多酚、益生菌补充剂、草药补充剂等营养补充剂可以减轻炎症，增强皮肤健康。缺乏维生素 D 等营养素可能会导致牛皮癣的发生。针对炎症途径、平衡肠道微生物群和解决营养缺乏问题可以改善银屑病的治疗效果。要证明天然生物活性物质的抗银屑病活性和调节肠道-大脑-皮肤轴的能力，还需要使用封装的天然生物活性物质进行大规模临床试验。

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引用次数: 0

Can L-Methionine and S-Adenosyl-L-Methionine Effectively Mitigate Scopolamine-Induced Cognitive and Motor Deficits in Mice? L-蛋氨酸和 S-腺苷-L-蛋氨酸能否有效缓解东莨菪碱诱导的小鼠认知和运动障碍？

IF 2.4 Q3 NUTRITION & DIETETICS

PharmaNutrition

Pub Date : 2024-10-10 DOI: 10.1016/j.phanu.2024.100415

Motor balance deficits often coincide with cognitive deficits in older adults. Current medications provide temporary relief with several potential side effects. Essential amino acids and their derivatives, such as S-Adenosyl-L-Methionine (SAMe), can improve nerve function, mood regulation, and neuroprotection against neurodegenerative diseases. This study investigated the protective effects of SAMe in scopolamine-degraded memory, and motor balance in an animal model.

To evaluate the possible effects of SAMe on cognitive and motor balance improvement, both Shuttle box and rotarod methods were performed in seven groups of animals (n=7). The mice groups received the saline (control), scopolamine, scopolamine+rivastigmine, scopolamine +methionine, and scopolamine+ three different doses of SAMe daily and separately for two weeks. Data were analyzed independently by one-way ANOVA and P<0.05 was considered significant.

SAMe 150 mg/kg worsened scopolamine-induced memory impairment (P<0.001), while methionine (100 mg/kg) or SAMe (only 100 mg/kg) together with scopolamine could reduce the duration of the animal's presence in the dark chamber (P<0.05). Daily administration of methionine and SAMe at the rate of 100 mg/kg daily could significantly improve the decrease in motor balance caused by scopolamine (P<0.05). Rivastigmine improved memory and motor balance impairment caused by scopolamine (P<0.05). No difference between SAMe and L-methionine for memory, and balance.

The results suggest that while L-methionine and SAMe may not be effective in improving memory impairments (Even SAMe high doses can aggravate the destruction of passive avoidance memory), they may be beneficial in enhancing motor balance.

运动平衡失调往往与老年人的认知障碍同时存在。目前的药物只能暂时缓解症状，但有一些潜在的副作用。必需氨基酸及其衍生物，如 S-腺苷-L-蛋氨酸（SAMe），可以改善神经功能、调节情绪，并对神经退行性疾病起到保护作用。为了评估 SAMe 对改善认知和运动平衡可能产生的影响，研究人员对七组动物（n=7）进行了梭箱法和旋转法实验。小鼠组每天分别接受生理盐水（对照组）、东莨菪碱、东莨菪碱+利伐斯的明、东莨菪碱+蛋氨酸和东莨菪碱+三种不同剂量的SAMe，持续两周。SAMe 150 mg/kg可加重东莨菪碱诱导的记忆损伤（P<0.001），而蛋氨酸（100 mg/kg）或SAMe（仅100 mg/kg）与东莨菪碱一起使用可缩短动物在暗室中的停留时间（P<0.05）。每天服用100毫克/千克蛋氨酸和SAMe可显著改善东莨菪碱导致的运动平衡能力下降（P<0.05）。利伐斯的明能改善东莨菪碱引起的记忆和运动平衡障碍（P<0.05）。结果表明，虽然L-蛋氨酸和SAMe可能无法有效改善记忆障碍（即使SAMe剂量过高也会加重被动回避记忆的破坏），但它们可能有益于增强运动平衡能力。

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引用次数: 0

Melatonin supplementation in preclinical colitis models: A systematic review and dose-response meta-analysis on inflammation, oxidative stress, and colon repair 在临床前结肠炎模型中补充褪黑素：关于炎症、氧化应激和结肠修复的系统综述和剂量反应荟萃分析

IF 2.4 Q3 NUTRITION & DIETETICS

PharmaNutrition

Pub Date : 2024-10-08 DOI: 10.1016/j.phanu.2024.100414

Background

Ulcerative colitis (UC), an autoimmune form of inflammatory bowel disease (IBD), leads to chronic inflammation of the colon. Existing treatments often fall short, highlighting the need for alternative or supplementary therapies. Melatonin, known for its antioxidant and anti-inflammatory effects, shows promise in this context. Thus, this study conducts a dose-response meta-analysis and systematic review of preclinical models to evaluate melatonin's effectiveness in UC.

Methods

Extensive searches in PubMed, Scopus, Embase, and Web of Science were performed, adhering to SYRCLE’s risk of bias guidelines, and registered with PROSPERO (CRD42024511595). Random-effects models calculated standard mean differences (SMD) and 95 % confidence intervals (CI) for disease activity indices, inflammatory markers, and antioxidant defenses.

Results

Out of 860 screened records, 72 studies met the inclusion criteria. Melatonin was found to significantly lower the ulcer index (SMD = −3.19) and malondialdehyde levels (SMD = −2.31). It also notably suppressed key pro-inflammatory mediators, including TNF-α (SMD = −1.14), IL-6 (SMD = −1.44), IL-1β (SMD = −1.63) and IL-17 (SMD = −1.77), while enhancing antioxidant defenses, particularly glutathione levels (SMD = 2.80). Furthermore, melatonin effectively modulated critical inflammatory regulators including nuclear factor kappa B (SMD = −1.97) and cyclooxygenase-2 (SMD = −1.34). The optimal therapeutic dose was identified as up to 10 mg/kg, with the highest efficacy observed via intraperitoneal and intracolonic administration routes.

Conclusion

Melatonin showed significant anti-inflammatory, antioxidant and tissue-repairing benefits in preclinical UC models, supporting clinical trials to confirm its therapeutic potential and optimal dosing.

背景溃疡性结肠炎（UC）是炎症性肠病（IBD）的一种自身免疫形式，会导致结肠慢性炎症。现有的治疗方法往往效果不佳，因此需要替代或辅助疗法。褪黑素以其抗氧化和抗炎作用而闻名，在这方面大有可为。因此，本研究对临床前模型进行了剂量反应荟萃分析和系统综述，以评估褪黑激素对 UC 的有效性。方法在 PubMed、Scopus、Embase 和 Web of Science 中进行了广泛的检索，遵守了 SYRCLE 的偏倚风险指南，并在 PROSPERO（CRD42024511595）上进行了注册。随机效应模型计算了疾病活动指数、炎症标志物和抗氧化防御能力的标准平均差（SMD）和95%置信区间（CI）。研究发现，褪黑素能明显降低溃疡指数（SMD = -3.19）和丙二醛水平（SMD = -2.31）。它还明显抑制了主要的促炎介质，包括TNF-α（SMD =-1.14）、IL-6（SMD =-1.44）、IL-1β（SMD =-1.63）和IL-17（SMD =-1.77），同时提高了抗氧化防御能力，特别是谷胱甘肽水平（SMD = 2.80）。此外，褪黑素还能有效调节关键的炎症调节因子，包括核因子卡巴B（SMD =-1.97）和环氧化酶-2（SMD =-1.34）。结论褪黑素在临床前 UC 模型中显示出显著的抗炎、抗氧化和组织修复功效，支持临床试验以确认其治疗潜力和最佳剂量。

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引用次数: 0

Efficacy and safety of liraglutide on C-reactive protein (CRP) in adults with type 2 diabetes: A GRADE-assessed systematic review and dose-response meta-analysis of controlled trials 利拉鲁肽对成人 2 型糖尿病患者 C 反应蛋白 (CRP) 的疗效和安全性：对对照试验进行GRADE评估的系统综述和剂量反应荟萃分析

IF 2.4 Q3 NUTRITION & DIETETICS

PharmaNutrition

Pub Date : 2024-09-18 DOI: 10.1016/j.phanu.2024.100409

Background

Liraglutide (LRG) is an analog of glucagon-like-peptide-1 which has beneficial effects on controlling glycemic in diabetes patients. However, the effect of liraglutide on the C-reactive protein (CRP) was controversial in different studies. So, this study aimed to investigate the effect of LRG on CRP in adults with type 2 diabetes (T2DM).

Methods

Through March 2024, Web of Science, PubMed, and Scopus electronic databases were searched for pertinent studies. Calculation of 95 % confidence intervals (CIs) and mean differences was done using random effects model. Standard methods assessed dose-response, meta-regression, sensitivity, and publication bias. GRADE (Grading of Recommendations Assessment, Development, and Evaluation) was used to calculate evidence certainty.

Results

Finally, after reviewing 9 eligible studies with 10 arms including 1494 participants, a significant decrease in CRP levels was observed after treatment with LRG (WMD = −0.692 mg/L, 95 % CI: −1.01, −0.37, P<0.001). According to the results of the subgroup, LRG had greater effects in obese patients (Body mass index ≥30), high-quality studies, dosages >1.6 mg/d and durations ≥24 weeks. Linear (P<0.001) and non-linear (P _{dose-response} =0.009) dose-response associations were observed between LRG dosages and CRP levels. According to the GRADE, evidence for CRP was high.

Conclusions

LRG had beneficial effects on CRP levels in adults with T2DM, especially in obese patients.

背景利拉鲁肽（LRG）是胰高血糖素样肽-1的类似物，对控制糖尿病患者的血糖有好处。然而，不同研究对利拉鲁肽对C反应蛋白（CRP）的影响存在争议。因此，本研究旨在探讨利拉鲁肽对成人 2 型糖尿病（T2DM）患者 CRP 的影响。方法截至 2024 年 3 月，在 Web of Science、PubMed 和 Scopus 电子数据库中检索了相关研究。使用随机效应模型计算95%置信区间（CI）和平均差异。采用标准方法评估剂量反应、元回归、敏感性和发表偏倚。结果最终，在回顾了9项符合条件的研究，共10个研究臂，包括1494名参与者后，观察到LRG治疗后CRP水平显著下降（WMD = -0.692 mg/L，95 % CI：-1.01，-0.37，P<0.001）。根据亚组结果，LRG对肥胖患者（体重指数≥30）、高质量研究、剂量>1.6 mg/d、持续时间≥24周的疗效更好。LRG剂量与CRP水平之间存在线性（P<0.001）和非线性（P剂量-反应=0.009）剂量-反应关系。结论LRG对患有T2DM的成人，尤其是肥胖患者的CRP水平有益处。

{"title":"Efficacy and safety of liraglutide on C-reactive protein (CRP) in adults with type 2 diabetes: A GRADE-assessed systematic review and dose-response meta-analysis of controlled trials","authors":"","doi":"10.1016/j.phanu.2024.100409","DOIUrl":"10.1016/j.phanu.2024.100409","url":null,"abstract":"<div><h3>Background</h3><p>Liraglutide (LRG) is an analog of glucagon-like-peptide-1 which has beneficial effects on controlling glycemic in diabetes patients. However, the effect of liraglutide on the C-reactive protein (CRP) was controversial in different studies. So, this study aimed to investigate the effect of LRG on CRP in adults with type 2 diabetes (T2DM).</p></div><div><h3>Methods</h3><p>Through March 2024, Web of Science, PubMed, and Scopus electronic databases were searched for pertinent studies. Calculation of 95 % confidence intervals (CIs) and mean differences was done using random effects model. Standard methods assessed dose-response, meta-regression, sensitivity, and publication bias. GRADE (Grading of Recommendations Assessment, Development, and Evaluation) was used to calculate evidence certainty.</p></div><div><h3>Results</h3><p>Finally, after reviewing 9 eligible studies with 10 arms including 1494 participants, a significant decrease in CRP levels was observed after treatment with LRG (WMD = −0.692 mg/L, 95 % CI: −1.01, −0.37, P<0.001). According to the results of the subgroup, LRG had greater effects in obese patients (Body mass index ≥30), high-quality studies, dosages >1.6 mg/d and durations ≥24 weeks. Linear (P<0.001) and non-linear (P <sub>dose-response</sub> =0.009) dose-response associations were observed between LRG dosages and CRP levels. According to the GRADE, evidence for CRP was high.</p></div><div><h3>Conclusions</h3><p>LRG had beneficial effects on CRP levels in adults with T2DM, especially in obese patients.</p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142274060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The guardians of macular health: Omega 3 fatty acids 黄斑健康的守护者奥米加 3 脂肪酸

IF 2.4 Q3 NUTRITION & DIETETICS

PharmaNutrition

Pub Date : 2024-09-01 DOI: 10.1016/j.phanu.2024.100408

引用次数: 0

Nurturing hope: Uncovering the potential of herbal remedies against amyotrophic lateral sclerosis 培育希望：挖掘草药治疗肌萎缩性脊髓侧索硬化症的潜力

IF 2.4 Q3 NUTRITION & DIETETICS

PharmaNutrition

Pub Date : 2024-09-01 DOI: 10.1016/j.phanu.2024.100406

Background

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, as currently available medications such as riluzole and edaravone aim to slow disease progression and manage symptoms, they are often expensive, have adverse side effects, and offer limited therapeutic outcomes. Therefore, it is crucial to explore complementary and alternative medicines in ALS treatment along with their possible mechanism(s). This paper investigates the potential benefits of herbal remedies in ALS management, focusing on their ability to alleviate symptoms, improve quality of life, and potentially delay disease progression.

Method

The review includes articles published from 1999 to 2024 and were searched using various databases including Web of Science, Scopus, Google Scholar and Clinical trial. The search was performed using different keywords such as ‘amyotrophic lateral sclerosis’, ‘pathogenesis’, ‘prevalence’, ‘herbal products’, ‘natural medicines’, ‘safety’, ‘efficacy’, ‘clinical trials’, ‘herbal-drug interaction’, ‘in vitro’, ‘in vivo’, phytochemicals, ‘alternative medicine’. Further studies were screening by assessing abstracts, cross references and previously published review and research articles.

Results

A number of herbal products are reported in preclinical and clinical studies indicating their efficacy against ALS. These prominent phytoconstituents exhibiting anti- amyotrophic lateral sclerosis effect are mainly present in different parts of the plant and include curcumin, epigallocatechin gallate, quercetin, resveratrol, tetrahydrocannabidiol, diallyl trisulfide, withanolides, genistein, and madecassoside. The plant extract containing these phytoconstituents exert their therapeutic effect via modulating inflammatory mediators, trapping free radicals, targeting various enzymes and/or by harnessing autophagy.

Conclusion

Although, various preclinical studies have shown beneficial effects of herbs in treating this debilitating disease. Further investigation is necessary to confirm the safety and efficacy of these botanical therapies in clinics.

背景肌萎缩性脊髓侧索硬化症（ALS）是一种致命的神经退行性疾病，目前可用的药物（如利鲁唑和依达拉奉）旨在延缓疾病进展和控制症状，但这些药物通常价格昂贵，有不良副作用，而且治疗效果有限。因此，探索辅助和替代药物在 ALS 治疗中的作用及其可能的机制至关重要。本文研究了草药在 ALS 治疗中的潜在益处，重点关注草药缓解症状、改善生活质量和潜在延缓疾病进展的能力。方法该综述包括 1999 年至 2024 年发表的文章，并使用各种数据库进行检索，包括 Web of Science、Scopus、Google Scholar 和 Clinical trial。检索时使用了不同的关键词，如 "肌萎缩侧索硬化症"、"发病机制"、"患病率"、"草药产品"、"天然药物"、"安全性"、"有效性"、"临床试验"、"草药与药物的相互作用"、"体外"、"体内"、植物化学物质、"替代医学"。通过评估摘要、交叉参考文献和以前发表的综述和研究文章，筛选出更多的研究结果。这些具有抗肌萎缩性脊髓侧索硬化症功效的植物成分主要存在于植物的不同部位，包括姜黄素、表没食子儿茶素没食子酸酯、槲皮素、白藜芦醇、四氢大麻酚、二烯丙基三硫化物、山檀内酯、染料木素和马德拉苷。含有这些植物成分的植物提取物通过调节炎症介质、捕获自由基、靶向各种酶和/或利用自噬作用发挥其治疗效果。有必要开展进一步调查，以确认这些植物疗法在临床中的安全性和有效性。

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引用次数: 0

Nano-curcumin supplementation for the management of migraine: A systematic scoping review and meta-analysis 补充纳米姜黄素治疗偏头痛：系统性范围审查和荟萃分析

IF 2.4 Q3 NUTRITION & DIETETICS

PharmaNutrition

Pub Date : 2024-09-01 DOI: 10.1016/j.phanu.2024.100407

Objectives

Migraine is a common neurological disorder contributing significantly to global disability. Nano-curcumin, known for its anti-inflammatory and neuroprotective properties, has emerged as a promising candidate for migraine prophylaxis. Herein, we assessed the effects of nano-curcumin supplementation on headache attack, severity, and duration in adult patients.

Methods

Five biomedical databases were searched until March 2024 for randomized controlled trials (RCTs). 13 records fulfilled the inclusion criteria, eight of which were considered for meta-analysis. The risk of bias was assessed using ROB2. Outcomes were quantified using both Standardized Mean Difference (SMD) and Mean Difference (MD) along with the 95 % Confidence Intervals (CIs). Pooled intervention effects were estimated using both common-effects and random-effects models.

Results

Our analysis revealed that 80 mg nano-curcumin supplementation per day for two months in young adults reduced migraine attacks (SMD −0.55; 95 % CI: −1.07 to −0.02), severity (SMD −0.64; 95 % CI: −1.10 to −0.19), and duration (MD −2.90; 95 % CI: −4.66 to −1.13) when compared with placebo. When combined with nutraceuticals such as omega-3 and coenzyme Q10, nano-curcumin demonstrated enhanced efficacy in reducing migraine attacks (SMD 1.19; 95 % CI: 0.90–1.48). Among those who received nano-curcumin supplementation only, a before and after intervention analysis showed a reduction in migraine attacks (SMD −0.77; 95 % CI: −1.00 to −0.54), severity (SMD −0.92; 95 % CI: −1.50 to −0.33), and duration (SMD −0.63; 95 % CI: −1.05 to −0.20).

Conclusions

Evidence from literature suggests that nano-curcumin supplementation might be effective in reducing migraine symptoms. However, caution is advised, and further research is recommended to confirm these findings, considering the single institutional source of all studies.

目的偏头痛是一种常见的神经系统疾病，严重导致全球残疾。纳米姜黄素以其抗炎和保护神经的特性而闻名，已成为预防偏头痛的一种有前途的候选药物。在此，我们评估了补充纳米姜黄素对成年患者头痛发作、严重程度和持续时间的影响。方法在 2024 年 3 月之前，我们在五个生物医学数据库中搜索了随机对照试验（RCT）。13条记录符合纳入标准，其中8条被考虑进行荟萃分析。使用 ROB2 对偏倚风险进行了评估。采用标准化平均差 (SMD) 和平均差 (MD) 以及 95 % 置信区间 (CI) 对结果进行量化。结果我们的分析表明，与安慰剂相比，每天补充 80 毫克纳米姜黄素两个月可减少年轻成人偏头痛的发作（SMD -0.55；95 % CI：-1.07 至 -0.02）、严重程度（SMD -0.64；95 % CI：-1.10 至 -0.19）和持续时间（MD -2.90；95 % CI：-4.66 至 -1.13）。当纳米姜黄素与欧米伽-3和辅酶Q10等营养保健品结合使用时，纳米姜黄素在减少偏头痛发作方面显示出更强的疗效（SMD 1.19；95 % CI：0.90-1.48）。在仅接受纳米姜黄素补充剂的人群中，干预前后分析显示偏头痛发作次数（SMD -0.77；95 % CI：-1.00 至 -0.54）、严重程度（SMD -0.92；95 % CI：-1.50 至 -0.33）和持续时间（SMD -0.63；95 % CI：-1.05 至 -0.20）均有所减少。然而，考虑到所有研究的单一机构来源，建议谨慎行事，并开展进一步研究以证实这些发现。

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引用次数: 0

Biological activities from açaí (Euterpe spp. Mart.) seeds and their pharmacological aspects: A systematic review and meta-analysis 阿萨伊（Euterpe spp. Mart.）种子的生物活性及其药理作用：系统回顾和荟萃分析

IF 2.4 Q3 NUTRITION & DIETETICS

PharmaNutrition

Pub Date : 2024-08-10 DOI: 10.1016/j.phanu.2024.100405

Background

Açaí seeds, a by-product of açaí processing (1445 tons year⁻¹), make up 85 % of the fruit's weight and are rich in phenolic compounds, such as phenolic acids, (epi)catechins, and procyanidins. Their chemical profile suggests significant pharmacological potential, leading to growing interest in their therapeutic applications.

Methods

A systematic review was conducted following PRISMA guidelines, covering studies from 2006 to 2023.

Results

The review included 72 studies, 13 of which were cluster randomized trials in rodents. Açaí seed extract (ASE) displayed a robust phenolic profile with varying polymerization degrees. Preclinical investigations demonstrated ASE's therapeutic efficacy, showing potent antioxidant activities, upregulation of antioxidant enzymes via Nrf2 activation, and selective cytotoxicity against various cancer cell lines. ASE also exhibited efficacy in reducing oxidative stress, inflammatory cytokines, and inhibiting adipogenesis, addressing metabolic syndrome in rodents. Promising effects were observed on hypertension, hyperglycemia, dyslipidemia, and liver diseases, indicating broad health benefits.

Conclusion

Despite study heterogeneity, ASE's shows potential as a therapeutic agent., necessitating further clinical investigations to comprehensively evaluate its safety and efficacy in human health.

背景阿萨伊种子是阿萨伊加工的副产品（年产量为 1445 吨），占水果重量的 85%，富含酚类化合物，如酚酸、（表）儿茶素和原花青素。方法按照 PRISMA 指南对 2006 年至 2023 年的研究进行了系统综述。结果综述包括 72 项研究，其中 13 项是在啮齿类动物中进行的分组随机试验。阿萨伊籽提取物（ASE）显示出不同聚合度的强大酚类特征。临床前研究证明了阿萨伊籽提取物的治疗功效，显示出强大的抗氧化活性、通过激活 Nrf2 上调抗氧化酶以及对各种癌细胞株的选择性细胞毒性。ASE 还具有降低氧化应激、炎症细胞因子和抑制脂肪生成的功效，可用于治疗啮齿动物的代谢综合征。尽管研究结果不尽相同，但 ASE 仍显示出作为治疗剂的潜力，有必要进一步开展临床研究，以全面评估其对人类健康的安全性和有效性。

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引用次数: 0

Combinations of bacterial probiotics and yeast postbiotics influence fat deposition and growth in the nematode C. elegans 细菌益生菌和酵母后益生菌的组合影响线虫的脂肪沉积和生长

IF 2.4 Q3 NUTRITION & DIETETICS

PharmaNutrition

Pub Date : 2024-08-05 DOI: 10.1016/j.phanu.2024.100404

Background

Probiotics are live microorganisms with intended benefits on human health including obesity. As a small and fast-growing whole organism model, Caenorhabditis elegans has been used to assess the health effects of probiotics where mechanisms can be assessed through available genetic tools. Results from C. elegans can provide data on the effect of specific probiotic strains and combinations with prebiotics and postbiotics on health-related physiology to inform selections of interventions for further study. We hypothesized that specific combinations with prebiotics and postbiotics could both speed up worm development and reduce fat deposition, suggesting they allow for more effective nutrient utilization.

Methods

Here we expose C. elegans to the ABB S20 strain of Lactiplantibacillus plantarum in combination with different prebiotics and postbiotics. We then measure how these affect growth and development speed as well as fat deposition by measuring the time until the appearance of progeny and measuring Oil Red O staining respectively.

Results

Our results show that the combination of probiotic L. plantarum ABB S20 plus the postbiotic inactive yeasts K. marxianus ABB S8 and S. boulardii ABB S3 resulted in fast growth and reduced fat deposition compared to L. plantarum ABB S20 alone.

Conclusion

These results demonstrate the usefulness of C. elegans as a model to efficiently screen though combinations of probiotics, prebiotics and postbiotics to find those that are candidates to help with effective nutrition use and therefore weight management.

背景益生菌是活的微生物，对人类健康（包括肥胖症）具有预期的益处。作为一种小型、快速生长的全生物体模型，秀丽隐杆线虫（Caenorhabditis elegans）已被用于评估益生菌对健康的影响，其机制可通过现有的遗传工具进行评估。线虫的研究结果可以提供特定益生菌菌株以及益生菌与益生元和益生元组合对健康相关生理学影响的数据，为选择干预措施进行进一步研究提供依据。我们假设，益生菌与益生元的特定组合既能加快蠕虫的生长发育，又能减少脂肪沉积，这表明它们能更有效地利用营养物质。结果我们的研究结果表明，益生菌植物乳杆菌 ABB S20 与后效益生菌非活性酵母 K. marxianus ABB S8 和 S. boulardii ABB S3 的结合使用会对生长和发育速度以及脂肪沉积产生影响。结论：这些结果表明，利用秀丽隐杆线虫作为模型，可以有效地筛选益生菌、益生元和益后元的组合，从而找到有助于有效利用营养和控制体重的候选益生菌。

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