Synthesis, Characterization and In vitro Antibacterial Activity of Novel Ligand and its Metal Complexes

Abstract

1H-benzimidazole reacting with chloroacetone yielded 1-(1H-Benzo[d]imidazol-1-yl) propan-2-one.1-(1H-Benzo[d]imidazol-1-yl) propan-2-one further reacts with thiosemicarbazone to form novel ligand,2-(1-(1H- benzo[d] imidazol-1-yl) propan-2-ylidene) hydrazine carbo thioamide (BITS). Cu+2, Co+2, Ni+2, Mn+2 and Zn+2 metal complexes of BITS were synthesised from ligand BITS. Elemental analysis, IR-NMR spectral analysis, metal: ligand ratio and magnetic properties of all the ligand BITS and all metal complexes were characterized. The ligand BITS and all metal complexes also were screened for antibacterial Activity.