Polyphenol‐mediated construction of highly stable and bioactive selenium nanoparticles

IF 1.6 Q4 ENGINEERING, BIOMEDICAL Biosurface and Biotribology Pub Date : 2023-10-19 DOI:10.1049/bsb2.12067
Rong Hu, Xiao Wang, Lu Han, Xiong Lu
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Abstract

Abstract Selenium (Se), a well‐known essential element in human health, plays a vital role in regulating metabolism owing to its antioxidative nature. However, organic Se compounds are toxic and cannot be used for biomedical applications. Selenium nanoparticles (SeNPs) exhibit low biological toxicity and high bioavailability; however, they are prone to aggregation and are extremely unstable, thereby diminishing their bioactivity and bioavailability. To overcome these limitations, ultra‐small, highly stable, and bioactive SeNPs were synthesised based on an in‐situ hybridisation strategy by using polyphenol‐grafted‐chitosan (GA‐CS) to control and restrict crystal growth of Se nanoparticles. The resultant GA‐CS@nSe exhibited an average particle size of ∼30 nm and was highly stable in aqueous solutions. In addition, GA‐CS@nSe displayed improved biocompatibility and enhanced antioxidative activity. Taken together, the authors provide a basis for polyphenol‐mediated construction of Se‐based particles with increased bioactivity.
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多酚介导的高稳定性和生物活性硒纳米颗粒的构建
硒(Se)是一种众所周知的人体健康必需元素,由于其抗氧化性质,在调节代谢中起着至关重要的作用。然而,有机硒化合物是有毒的,不能用于生物医学应用。硒纳米颗粒具有低生物毒性和高生物利用度的特点;然而,它们容易聚集,极不稳定,从而降低了它们的生物活性和生物利用度。为了克服这些限制,基于原位杂交策略,利用多酚接枝壳聚糖(GA - CS)来控制和限制硒纳米粒子的晶体生长,合成了超小、高度稳定和具有生物活性的SeNPs。合成的GA‐CS@nSe平均粒径为~ 30 nm,在水溶液中高度稳定。此外,GA‐CS@nSe显示出更好的生物相容性和增强的抗氧化活性。综上所述,作者为多酚介导构建具有更高生物活性的硒基颗粒提供了基础。
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来源期刊
Biosurface and Biotribology
Biosurface and Biotribology Engineering-Mechanical Engineering
CiteScore
1.70
自引率
0.00%
发文量
27
审稿时长
11 weeks
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