Cerasorb® for filling critical peri-implant defects

IF 0.4 Q4 DENTISTRY, ORAL SURGERY & MEDICINE Journal of Oral and Maxillofacial Surgery Medicine and Pathology Pub Date : 2023-10-15 DOI:10.1016/j.ajoms.2023.10.008
Ana Paula de Souza Faloni , Daniela Oliveira Marques , Thallita Pereira Queiroz , João Paulo Lima Machado , Yasmin Mayara Justo , Eloá Rodrigues Luvizuto , Roberta Okamoto , Pâmela Letícia dos Santos
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Abstract

Objective

Bone loss is a substantial challenge for oral rehabilitation, and immediate implants associated with biomaterials are a treatment option to minimize this condition. This study aimed to assess the repair of peri-implant defects filled with β-tricalcium phosphate.

Material and Method

Fifteen rabbits received two osteotomies in each tibia using a 6.1-mm-diameter trephine bur. Next, lance and helical drills were used to prepare the host tissues, and two implants were installed. The defects were filled per groups BC (blood clot) and Ce (Cerasorb®). After 15, 30, and 60 days, the animals were euthanized, and biomechanical, histological, and immunohistochemical analyses were performed.

Results

The biomechanical analysis did not show statistical differences intergroup. The morphological analysis showed bone neoformation around Cerasorb® particles and inside their pores only in the regions where the biomaterial was close to the host bone tissue. In all investigated periods, next to the host tissue, there were TRAP-positive osteoclasts in close contact with β-TCP particles, apparently reabsorbing them. However, the biomaterial caused an inflammatory response characterized by several mononucleated cells at 30 days and TRAP-negative multinucleated giant cells at 60 days.

Conclusion

Cerasorb® worked as an osteoconductor, considering that regions of bone neoformation were in close contact with the biomaterial around the host tissue.

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Cerasorb® 用于填补关键的种植体周围缺陷
目的骨质流失是口腔修复的一大挑战,而与生物材料相关的即刻种植体是减少这种情况的一种治疗选择。本研究旨在评估用 β-磷酸三钙填充的种植体周围缺损的修复效果。然后使用长枪钻和螺旋钻准备宿主组织,并安装两个植入物。按 BC 组(血块)和 Ce 组(Cerasorb®)填充缺损。15、30 和 60 天后,动物被安乐死,并进行生物力学、组织学和免疫组化分析。形态学分析表明,只有在生物材料接近宿主骨组织的区域,Cerasorb® 颗粒周围及其孔隙内才有骨新生。在所有调查期间,在宿主组织旁边都有 TRAP 阳性的破骨细胞与 β-TCP 颗粒密切接触,显然是在重新吸收这些颗粒。结论考虑到骨新生区域与宿主组织周围的生物材料密切接触,Cerasorb® 可作为骨诱导剂发挥作用。
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来源期刊
CiteScore
0.80
自引率
0.00%
发文量
129
审稿时长
83 days
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