Journal of Oral and Maxillofacial Surgery Medicine and Pathology最新文献

Is elective neck dissection effective for clinical cervical node-negative oral squamous cell carcinoma? A systematic review and meta-analysis for the update of the 2019 Japanese Oral Cancer Clinical Practice Guidelines

IF 0.4 Q4 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Oral and Maxillofacial Surgery Medicine and Pathology

Pub Date : 2024-10-02 DOI: 10.1016/j.ajoms.2024.09.012

Daisuke Takeda , Nobuhiro Ueda , Shintaro Sukegawa , Masatoshi Adachi , Hidemichi Yuasa , Taiki Suzuki , Narikazu Uzawa , Hiroshi Kurita

Objective

There is no consensus on whether elective neck dissection should be performed for potential cervical lymph node metastases in patients with clinical cervical node-negative oral cancer. The aim of the present updated systematic review was to clarify the efficacy of elective neck dissection concurrently with resection of the primary tumor in patients with clinical cervical node-negative oral cancer.

Methods

The MEDLINE, Cochrane Central Register of Controlled Trials, and Ichushi-Web databases were searched to identify relevant randomized controlled trials (RCTs). We performed a statistical analysis using the Review Manager 5.4 computer program and assessed the certainty of evidence using the Grading of Recommendations Assessment, Development and Evaluation approach.

Results

Five RCTs were included. The meta-analysis revealed that the hazard ratios for overall survival, disease-free survival, and locoregional control were significantly in favor of elective neck dissection concurrently with resection of the primary tumor. Additionally, the risk difference for shoulder dysfunction after neck dissection was significantly in favor of resection of the primary tumor alone, although this outcome was only investigated in one RCT. The certainty of evidence was low for overall survival, disease-free survival, locoregional control, and shoulder dysfunction after neck dissection.

Conclusion

The present updated systematic review suggests that elective neck dissection should be performed concurrently with resection of the primary tumor in patients with clinical cervical node-negative oral cancer; however, the certainty of evidence was low. Future systematic reviews, including RCTs with larger samples, are expected to confirm the present findings.

{"title":"Is elective neck dissection effective for clinical cervical node-negative oral squamous cell carcinoma? A systematic review and meta-analysis for the update of the 2019 Japanese Oral Cancer Clinical Practice Guidelines","authors":"Daisuke Takeda , Nobuhiro Ueda , Shintaro Sukegawa , Masatoshi Adachi , Hidemichi Yuasa , Taiki Suzuki , Narikazu Uzawa , Hiroshi Kurita","doi":"10.1016/j.ajoms.2024.09.012","DOIUrl":"10.1016/j.ajoms.2024.09.012","url":null,"abstract":"<div><h3>Objective</h3><div>There is no consensus on whether elective neck dissection should be performed for potential cervical lymph node metastases in patients with clinical cervical node-negative oral cancer. The aim of the present updated systematic review was to clarify the efficacy of elective neck dissection concurrently with resection of the primary tumor in patients with clinical cervical node-negative oral cancer.</div></div><div><h3>Methods</h3><div>The MEDLINE, Cochrane Central Register of Controlled Trials, and Ichushi-Web databases were searched to identify relevant randomized controlled trials (RCTs). We performed a statistical analysis using the Review Manager 5.4 computer program and assessed the certainty of evidence using the Grading of Recommendations Assessment, Development and Evaluation approach.</div></div><div><h3>Results</h3><div>Five RCTs were included. The meta-analysis revealed that the hazard ratios for overall survival, disease-free survival, and locoregional control were significantly in favor of elective neck dissection concurrently with resection of the primary tumor. Additionally, the risk difference for shoulder dysfunction after neck dissection was significantly in favor of resection of the primary tumor alone, although this outcome was only investigated in one RCT. The certainty of evidence was low for overall survival, disease-free survival, locoregional control, and shoulder dysfunction after neck dissection.</div></div><div><h3>Conclusion</h3><div>The present updated systematic review suggests that elective neck dissection should be performed concurrently with resection of the primary tumor in patients with clinical cervical node-negative oral cancer; however, the certainty of evidence was low. Future systematic reviews, including RCTs with larger samples, are expected to confirm the present findings.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 2","pages":"Pages 263-271"},"PeriodicalIF":0.4,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143150355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combination treatment with hyaluronic acid synthesis and Bcl-2 inhibitors induces senolytic elimination of oral squamous cell carcinoma cells in vitro

IF 0.4 Q4 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Oral and Maxillofacial Surgery Medicine and Pathology

Pub Date : 2024-09-10 DOI: 10.1016/j.ajoms.2024.09.003

Kumiko Kamada , Naito Kurio , Yasuhiro Mouri , Yasusei Kudo

Objective

Hyaluronic acid (HA) is a major glycosaminoglycan in the extracellular matrix and plays a vital role in cancer progression. HA interacts with cell membrane receptors, such as receptor for HA-mediated motility (RHAMM), to regulate the cell cycle and cell division. 4-Methylumbelliferone (4-MU) is a well-known HA synthesis inhibitor and a promising cancer therapy alternative. 4-MU is a coumarin derivative with no obvious side effects and has been studied in several cancers. However, little is known about its use in oral squamous cell carcinoma (OSCC). In this study, we evaluated the antitumor effects of 4-MU on OSCC cells.

Methods

The effects of 4-MU on HAS gene and HA-related protein expression were evaluated with RT-qPCR and Western blotting. The effects on HA secretion was confirmed by ELISA. The effects on cell proliferation were confirmed by MTS assay. Trypan blue exclusion assay was used for cell viability assay. Cell cycle analysis, cell-clock cell cycle assay, and apoptosis assay were used to determine the effects on cell cycle and apoptosis. SA-β-gal staining was used to evaluate senescence.

Results

4-MU induced senescence change in OSCC cells by overexpression of the anti-apoptotic protein Bcl-2 and markedly suppressed their proliferation. Furthermore, following administration of Bcl-2 inhibitor, ABT-263 known as a senescent cell eliminator can specifically induce apoptosis and eliminate the senescent OSCC cells.

Conclusions

These findings highlight the potential use of 4-MU in OSCC chemotherapy as a senescence-inducing agent that not only potently suppresses OSCC cell proliferation but also enhances the efficacy of Bcl-2 inhibitor.

{"title":"Combination treatment with hyaluronic acid synthesis and Bcl-2 inhibitors induces senolytic elimination of oral squamous cell carcinoma cells in vitro","authors":"Kumiko Kamada , Naito Kurio , Yasuhiro Mouri , Yasusei Kudo","doi":"10.1016/j.ajoms.2024.09.003","DOIUrl":"10.1016/j.ajoms.2024.09.003","url":null,"abstract":"<div><h3>Objective</h3><div>Hyaluronic acid (HA) is a major glycosaminoglycan in the extracellular matrix and plays a vital role in cancer progression. HA interacts with cell membrane receptors, such as receptor for HA-mediated motility (RHAMM), to regulate the cell cycle and cell division. 4-Methylumbelliferone (4-MU) is a well-known HA synthesis inhibitor and a promising cancer therapy alternative. 4-MU is a coumarin derivative with no obvious side effects and has been studied in several cancers. However, little is known about its use in oral squamous cell carcinoma (OSCC). In this study, we evaluated the antitumor effects of 4-MU on OSCC cells.</div></div><div><h3>Methods</h3><div>The effects of 4-MU on HAS gene and HA-related protein expression were evaluated with RT-qPCR and Western blotting. The effects on HA secretion was confirmed by ELISA. The effects on cell proliferation were confirmed by MTS assay. Trypan blue exclusion assay was used for cell viability assay. Cell cycle analysis, cell-clock cell cycle assay, and apoptosis assay were used to determine the effects on cell cycle and apoptosis. SA-β-gal staining was used to evaluate senescence.</div></div><div><h3>Results</h3><div>4-MU induced senescence change in OSCC cells by overexpression of the anti-apoptotic protein Bcl-2 and markedly suppressed their proliferation. Furthermore, following administration of Bcl-2 inhibitor, ABT-263 known as a senescent cell eliminator can specifically induce apoptosis and eliminate the senescent OSCC cells.</div></div><div><h3>Conclusions</h3><div>These findings highlight the potential use of 4-MU in OSCC chemotherapy as a senescence-inducing agent that not only potently suppresses OSCC cell proliferation but also enhances the efficacy of Bcl-2 inhibitor.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 2","pages":"Pages 289-296"},"PeriodicalIF":0.4,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143150319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical and diagnostic features of salivary glands disease related to COVID-19 infection: A systematic review of the literature 与COVID-19感染相关的唾液腺疾病的临床和诊断特征：文献系统回顾

IF 0.4 Q4 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Oral and Maxillofacial Surgery Medicine and Pathology

Pub Date : 2024-09-07 DOI: 10.1016/j.ajoms.2024.08.011

Pierre Guarino , Francesco Chiari , Claudio Donadio Caporale , Livio Presutti , Gabriele Molteni

Purpose

Coronavirus disease 2019 (COVID-19) results from primary infection by severe acute respiratory syndrome coronavirus 2 (Sars COV-2). The transmission thereof is based on mucosal inoculation of infected droplets or direct contact from carriers. However, coronavirus viral loads can be found in throat wash and saliva specimens. The aim of this work is to make an overview about clinical and diagnostic information of patients affected by sialadenitis related to Sars COV-2 infection.

Methods

A systematic literature review has been performed following PRISMA 2020 checklist statement. A computerized search has been carried on by an extensive set of queries on the Embase/Pubmed, Scopus and Cochrane databases, relating to articles published from January 2020 to February 2024.

Results

Information reported within ten papers has been processed in this review. The total amount of patients included was 27 (55 % females), with a mean age of 35.6 years. All patients showed a parotid gland infection, which was described bilaterally in 45 % of cases. However, submandibular and sublingual gland infections were reported only as of a single patient. Sialadenitis diagnosis was made through clinical examination, radiological tools and laboratory tests. The diagnosis of parotitis was contextual or delayed to COVID-19 detection in 78 % and 22 % of cases, respectively. The therapeutic management thereof consisted of symptomatic therapies as in Sars COV-2 infection. Antibiotics were reserved in a few cases (12 %).

Conclusions

Sialadenitis in patients affected by Sars COV-2 is an uncommon manifestation of COVID-19 infection. Its treatment and prognosis do not differ from those used to treat patients affected by Sars COV-2.

目的 2019 年冠状病毒病（COVID-19）是由严重急性呼吸系统综合征冠状病毒 2（Sars COV-2）原发感染引起的。其传播途径是通过粘膜接种受感染的飞沫或直接接触带毒者。然而，冠状病毒病毒载量可在咽喉洗液和唾液标本中发现。本文旨在概述与萨斯COV-2感染相关的唾液腺炎患者的临床和诊断信息。通过在 Embase/Pubmed、Scopus 和 Cochrane 数据库中进行大量查询，对 2020 年 1 月至 2024 年 2 月期间发表的相关文章进行了计算机检索。共纳入 27 名患者（55% 为女性），平均年龄为 35.6 岁。所有患者均表现为腮腺感染，45%的病例为双侧感染。然而，仅有一名患者报告了颌下腺和舌下腺感染。腮腺炎症的诊断是通过临床检查、放射学工具和实验室检测做出的。78% 和 22% 的腮腺炎诊断与 COVID-19 检测相关或延迟。其治疗方法与萨斯COV-2感染一样，包括对症治疗。结论Sars COV-2感染者的咽鼓管炎是COVID-19感染的一种不常见表现。其治疗方法和预后与治疗 Sars COV-2 患者的方法并无不同。

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引用次数: 0

Dendritic cells and vascular endothelial growth factor-C in human oral squamous cell carcinoma

IF 0.4 Q4 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Oral and Maxillofacial Surgery Medicine and Pathology

Pub Date : 2024-09-05 DOI: 10.1016/j.ajoms.2024.09.002

Ayako Okuyama , Kenko Okamoto , Miki Haruyama , Shinnichi Sakamoto , Miyako Hoshino , Michiko Nishimura , Yuji Miyazaki , Takahiko Furuya , Nobuharu Yamamoto , Kentaro Kikuchi

Objective

Dendritic cells (DCs) are antigen-presenting cells that can activate naive T cells and thus play a role in tumor immunity. Vascular endothelial growth factors (VEGFs) produced and secreted by various cancers have been reported to inhibit DC differentiation from progenitor cells. However, the relationship between VEGF-C and DCs in oral squamous cell carcinoma (OSCC) remains unclear.

Methods

Formalin-fixed paraffin-embedded samples of 172 OSCCs were studied. Immunohistological staining was performed to determine the density of S100- and CD1a- positive DCs, D2–40-positive lymphatic vessels, and the grade of VEGF-C expression in OSCCs. OSCC cell lines were cultured and examined for VEGF-C secretion using ELISA.

Results

In comparison to pathological lymph node-negative (PN-) cases, the density of DCs in cancer tissues was significantly lower in PN-positive (PN+) cases, whereas the lymphatic vessel density of cancer tissues was significantly higher in PN+ cases. The density of DCs decreased significantly with increasing VEGF-C expression, indicating a weak inverse relationship. There was a strong positive correlation between VEGF-C expression and lymphatic vessel density. ELISA revealed VEGF-C secretion in various OSCC cell lines, particularly HSC-3, and this increased over time.

Conclusions

These results indicate that VEGF-C expressed by OSCC may increase lymphangiogenesis and create an environment that promotes lymph node metastasis.

{"title":"Dendritic cells and vascular endothelial growth factor-C in human oral squamous cell carcinoma","authors":"Ayako Okuyama , Kenko Okamoto , Miki Haruyama , Shinnichi Sakamoto , Miyako Hoshino , Michiko Nishimura , Yuji Miyazaki , Takahiko Furuya , Nobuharu Yamamoto , Kentaro Kikuchi","doi":"10.1016/j.ajoms.2024.09.002","DOIUrl":"10.1016/j.ajoms.2024.09.002","url":null,"abstract":"<div><h3>Objective</h3><div>Dendritic cells (DCs) are antigen-presenting cells that can activate naive T cells and thus play a role in tumor immunity. Vascular endothelial growth factors (VEGFs) produced and secreted by various cancers have been reported to inhibit DC differentiation from progenitor cells. However, the relationship between VEGF-C and DCs in oral squamous cell carcinoma (OSCC) remains unclear.</div></div><div><h3>Methods</h3><div>Formalin-fixed paraffin-embedded samples of 172 OSCCs were studied. Immunohistological staining was performed to determine the density of S100- and CD1a- positive DCs, D2–40-positive lymphatic vessels, and the grade of VEGF-C expression in OSCCs. OSCC cell lines were cultured and examined for VEGF-C secretion using ELISA.</div></div><div><h3>Results</h3><div>In comparison to pathological lymph node-negative (PN-) cases, the density of DCs in cancer tissues was significantly lower in PN-positive (PN+) cases, whereas the lymphatic vessel density of cancer tissues was significantly higher in PN+ cases. The density of DCs decreased significantly with increasing VEGF-C expression, indicating a weak inverse relationship. There was a strong positive correlation between VEGF-C expression and lymphatic vessel density. ELISA revealed VEGF-C secretion in various OSCC cell lines, particularly HSC-3, and this increased over time.</div></div><div><h3>Conclusions</h3><div>These results indicate that VEGF-C expressed by OSCC may increase lymphangiogenesis and create an environment that promotes lymph node metastasis.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 2","pages":"Pages 278-288"},"PeriodicalIF":0.4,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143150357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chondrolipoma arising in the tongue and related literature review: A report of two cases

IF 0.4 Q4 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Oral and Maxillofacial Surgery Medicine and Pathology

Pub Date : 2024-08-30 DOI: 10.1016/j.ajoms.2024.08.017

Takashi Baba , Yu Yamaguma , Takehito Fukui , Takeshi Kaneuji , Koji Kashima , Yoshihiro Yamashita

Chondrolipomas are rare benign tumors composed of mature adipocytes, a metaplastic chondromatrix, and cartilaginous chondrocytes. Herein, we present two cases of chondrolipoma of the tongue. The first case involved a 62-year-old woman who had a painless mass on the border of her tongue for four years; the second patient was a 74-year-old woman with a painless mass on the dorsal aspect of her tongue that had persisted for approximately six decades. Both cases were clinically diagnosed as benign tumors and the patients underwent surgical excision under general anesthesia. No local recurrence was observed during their 5-year postoperative follow-up periods. We further investigated 19 cases of chondrolipoma arising in the lip and oral cavity, including 17 previously reported cases and the two presented cases. The cartilage found in these tumors likely represents metaplastic changes or hamartomatous proliferation, attributed to the multipotentiality of mesenchymal stem cells.

引用次数: 0

Open reduction internal fixation versus closed reduction for the management of mandibular intra-capsular fractures in adult patients: A systematic review and meta-analysis

IF 0.4 Q4 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Oral and Maxillofacial Surgery Medicine and Pathology

Pub Date : 2024-08-30 DOI: 10.1016/j.ajoms.2024.08.018

Sameer Pandey , Saurabh S. Simre , Srinivedha CV , Ram Sundar Chaulagain , Akansha Vyas , Abiskar Basnet

Purpose

The management of mandibular condylar head/intra-capsular fractures is a controversial subject. Many centres still prescribe closed/ conservative management of this fracture based upon reasonably good functional rehabilitation and fear of surgical complications. The study aims to generate evidence for the selection of the best treatment (open reduction internal fixation, or closed reduction).

Material and methods

A systematic review of the literature was performed by searching four electronic databases. The protocol was registered in Prospero (CRD42022365919). Using well-defined PICOS criteria, all randomised and non-randomised studies comparing Open reduction internal fixation to a closed reduction of mandible condylar head fracture were included in the study. Eight were selected for final data analysis. The two treatment methods were compared using post-treatment TMJ dysfunction, malocclusion, facial nerve weakness and condylar resorption as outcomes. The statistical analysis was done using Revman 5.4 and MedCalc software.

Results

The meta-analysis results suggested better clinical TMJ function and less malocclusion with open reduction. Better mouth opening associated with closed reduction group. The proportional meta-analysis revealed a 3 % incidence of temporary facial nerve weakness and 47 % condylar resorption associated with open reduction internal fixation.

Conclusion

Open reduction internal fixation of mandible condylar head/intra-capsular fractures are associated with less clinical TMJ dysfunction and malocclusion than the closed reduction/conservative treatment.

{"title":"Open reduction internal fixation versus closed reduction for the management of mandibular intra-capsular fractures in adult patients: A systematic review and meta-analysis","authors":"Sameer Pandey , Saurabh S. Simre , Srinivedha CV , Ram Sundar Chaulagain , Akansha Vyas , Abiskar Basnet","doi":"10.1016/j.ajoms.2024.08.018","DOIUrl":"10.1016/j.ajoms.2024.08.018","url":null,"abstract":"<div><h3>Purpose</h3><div>The management of mandibular condylar head/intra-capsular fractures is a controversial subject. Many centres still prescribe closed/ conservative management of this fracture based upon reasonably good functional rehabilitation and fear of surgical complications. The study aims to generate evidence for the selection of the best treatment (open reduction internal fixation, or closed reduction).</div></div><div><h3>Material and methods</h3><div>A systematic review of the literature was performed by searching four electronic databases. The protocol was registered in Prospero (CRD42022365919). Using well-defined PICOS criteria, all randomised and non-randomised studies comparing Open reduction internal fixation to a closed reduction of mandible condylar head fracture were included in the study. Eight were selected for final data analysis. The two treatment methods were compared using post-treatment TMJ dysfunction, malocclusion, facial nerve weakness and condylar resorption as outcomes. The statistical analysis was done using Revman 5.4 and MedCalc software.</div></div><div><h3>Results</h3><div>The meta-analysis results suggested better clinical TMJ function and less malocclusion with open reduction. Better mouth opening associated with closed reduction group. The proportional meta-analysis revealed a 3 % incidence of temporary facial nerve weakness and 47 % condylar resorption associated with open reduction internal fixation.</div></div><div><h3>Conclusion</h3><div>Open reduction internal fixation of mandible condylar head/intra-capsular fractures are associated with less clinical TMJ dysfunction and malocclusion than the closed reduction/conservative treatment.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 2","pages":"Pages 255-262"},"PeriodicalIF":0.4,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143150354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tube feeding in patients with head and neck cancer undergoing chemoradio-/radio therapy: A systematic review and meta-analysis based on the GRADE approach 接受化疗/放疗的头颈部癌症患者的管饲：基于GRADE方法的系统综述和荟萃分析

IF 0.4 Q4 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Oral and Maxillofacial Surgery Medicine and Pathology

Pub Date : 2024-08-30 DOI: 10.1016/j.ajoms.2024.08.015

Taiki Suzuki , Souichi Yanamoto , Daisuke Takeda , Hirokazu Saito , Haruki Sato , Seiji Asoda , Masatoshi Adachi , Hidemichi Yuasa , Narikazu Uzawa , Hiroshi Kurita

Scope

The scope of this systematic review (SR) was to determine whether a nasogastric tube (NGT) or percutaneous endoscopic gastrostomy (PEG) is a more useful supportive therapy in patients with oral cancer undergoing chemoradio-/radio therapy.

Methods

For the review, two authors searched MEDLINE, Cochrane CENTRAL and Ichushi-Web to identify clinical practice guidelines, SRs and randomised controlled trials (RCTs) according to pre-determined criteria. RevMan Web was used to combine trials and analyse the data. We evaluated the certainty of the evidence using the Grading of Recommendations, Assessment, Development and Evaluation system approach.

Results

It was not possible to perform a meta-analysis of only treatment completion based on the included RCTs; therefore, we performed a meta-analysis of treatment breaks as a surrogate outcome. A meta-analysis of potential treatment breaks, including treatment discontinuation, revealed no superiority between PEG and NGT (risk ratio=0.64 [0.23, 1.79]). A meta-analysis was conducted on two RCTs regarding the harms of infection. There does not appear to be a significant increase in the risk of infection with either PEG or NGT (risk ratio=1.18 [0.45, 3.08]). The certainty of the evidence for two outcomes was judged to be very low. Further, meta-analyses of quality of life and nutritional status were not possible because of differences in assessment methods.

Conclusion

We could not determine the superiority of NGT or PEG in the supportive care of oral cancer patients who received chemoradio-/radio therapy. The effect of PEG feeding is uncertain, and it is necessary to consider indications for each case.

范围本系统综述（SR）的范围是确定对于接受化疗/放疗的口腔癌患者，鼻胃管 (NGT) 还是经皮内镜胃造瘘术 (PEG) 是一种更有用的支持疗法。方法在综述中，两位作者按照预先确定的标准检索了 MEDLINE、Cochrane CENTRAL 和 Ichushi-Web 以确定临床实践指南、SR 和随机对照试验 (RCT)。RevMan Web 用于合并试验和分析数据。我们采用推荐、评估、发展和评价系统分级法对证据的确定性进行了评估。结果根据纳入的随机对照试验，我们无法仅对治疗完成情况进行荟萃分析；因此，我们对治疗中断作为替代结果进行了荟萃分析。对包括治疗中断在内的潜在治疗中断进行的荟萃分析表明，PEG 和 NGT 之间没有优劣之分（风险比=0.64 [0.23, 1.79]）。对两项研究性试验进行了有关感染危害的荟萃分析。无论是 PEG 还是 NGT，感染风险似乎都没有显著增加（风险比=1.18 [0.45, 3.08]）。两项结果的证据确定性被认为很低。此外，由于评估方法不同，无法对生活质量和营养状况进行荟萃分析。结论我们无法确定 NGT 或 PEG 在对接受化疗/放疗的口腔癌患者进行支持性护理方面的优越性。PEG喂养的效果尚不确定，有必要考虑每个病例的适应症。

{"title":"Tube feeding in patients with head and neck cancer undergoing chemoradio-/radio therapy: A systematic review and meta-analysis based on the GRADE approach","authors":"Taiki Suzuki , Souichi Yanamoto , Daisuke Takeda , Hirokazu Saito , Haruki Sato , Seiji Asoda , Masatoshi Adachi , Hidemichi Yuasa , Narikazu Uzawa , Hiroshi Kurita","doi":"10.1016/j.ajoms.2024.08.015","DOIUrl":"10.1016/j.ajoms.2024.08.015","url":null,"abstract":"<div><h3>Scope</h3><div>The scope of this systematic review (SR) was to determine whether a nasogastric tube (NGT) or percutaneous endoscopic gastrostomy (PEG) is a more useful supportive therapy in patients with oral cancer undergoing chemoradio-/radio therapy.</div></div><div><h3>Methods</h3><div>For the review, two authors searched MEDLINE, Cochrane CENTRAL and Ichushi-Web to identify clinical practice guidelines, SRs and randomised controlled trials (RCTs) according to pre-determined criteria. RevMan Web was used to combine trials and analyse the data. We evaluated the certainty of the evidence using the Grading of Recommendations, Assessment, Development and Evaluation system approach.</div></div><div><h3>Results</h3><div>It was not possible to perform a meta-analysis of only treatment completion based on the included RCTs; therefore, we performed a meta-analysis of treatment breaks as a surrogate outcome. A meta-analysis of potential treatment breaks, including treatment discontinuation, revealed no superiority between PEG and NGT (risk ratio=0.64 [0.23, 1.79]). A meta-analysis was conducted on two RCTs regarding the harms of infection. There does not appear to be a significant increase in the risk of infection with either PEG or NGT (risk ratio=1.18 [0.45, 3.08]). The certainty of the evidence for two outcomes was judged to be very low. Further, meta-analyses of quality of life and nutritional status were not possible because of differences in assessment methods.</div></div><div><h3>Conclusion</h3><div>We could not determine the superiority of NGT or PEG in the supportive care of oral cancer patients who received chemoradio-/radio therapy. The effect of PEG feeding is uncertain, and it is necessary to consider indications for each case.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 1","pages":"Pages 92-98"},"PeriodicalIF":0.4,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142660156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tumor budding and complete epithelial mesenchymal transition correlate with late nodal metastasis in early-stage tongue squamous cell carcinoma 肿瘤出芽和完全上皮间质转化与早期舌鳞状细胞癌晚期结节转移有关

IF 0.4 Q4 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Oral and Maxillofacial Surgery Medicine and Pathology

Pub Date : 2024-08-30 DOI: 10.1016/j.ajoms.2024.08.012

Takayoshi Kikuchi , Kinue Kurihara , Homare Kawachi , Satoru Ogane , Kazuhiko Hashimoto , Takahiko Shibahara , Takeshi Nomura

Background

Late nodal metastasis is a poor prognostic factor for early-stage tongue squamous cell carcinoma. However, for most early-stage patients, there is a low risk for late nodal metastasis, which currently lacks a diagnostic marker. Tumor budding is a nodal metastasis risk factor in other human cancers. Here, we evaluated tumor budding by partial or complete epithelial-mesenchymal transition and Ovol2 expression, a transcription factor that directly suppresses epithelial-mesenchymal transition.

Methods

Sixty-six T1–2N0 patients were enrolled in this retrospective study. Tumor expressions of E-cadherin and vimentin (epithelial-mesenchymal transition markers) and Ovol2 were assessed by immunohistochemistry. Tumor histopathological and immunohistochemical features, mode of invasion, and tumor budding were assessed. Correlations between these potential predictive factors and late nodal metastasis were determined statistically.

Results

Univariate analysis demonstrated lymphoid infiltrate, perineural invasion, infiltrative growth pattern, tumor budding, vimentin positive, and complete epithelial-mesenchymal transition were significant factors of late nodal metastasis (all P < 0.05), observed in 25.8 % of patients. Multivariate analysis identified tumor budding and vimentin positive were independent prognostic factors (both P < 0.025). Ovol2 expression was significantly decreased in partial and complete epithelial-mesenchymal transition cells (both P < 0.01) compared with normal epithelia. Univariate analysis, but not multivariate analysis, showed Ovol2 correlated with depth of invasion and tumor budding (both P < 0.05).

Conclusion

Tumor budding and vimentin expression are risk factors for late nodal metastasis in T1–2N0 tongue squamous cell carcinoma. Ovol2 might be involved in the early stages of epithelial-mesenchymal transition. Evaluation of these factors might identify patients susceptible to late nodal metastasis who require elective neck dissection.

背景晚期结节转移是早期舌鳞状细胞癌的一个不良预后因素。然而，对于大多数早期患者来说，晚期结节转移的风险较低，目前缺乏诊断标志物。肿瘤萌芽是其他人类癌症的结节转移风险因素。在此，我们通过部分或完全的上皮-间质转化和Ovol2（一种直接抑制上皮-间质转化的转录因子）的表达来评估肿瘤萌芽。免疫组化法评估了肿瘤中E-cadherin和vimentin（上皮-间质转化标志物）以及Ovol2的表达。对肿瘤组织病理学和免疫组化特征、侵袭方式和肿瘤出芽进行了评估。结果单变量分析表明，淋巴细胞浸润、神经周围浸润、浸润生长模式、肿瘤出芽、波形蛋白阳性和完全上皮-间质转化是晚期结节转移的重要因素（均为 P < 0.05），在 25.8% 的患者中观察到。多变量分析发现，肿瘤出芽和波形蛋白阳性是独立的预后因素（均为 P < 0.025）。与正常上皮细胞相比，部分上皮-间质转化细胞和完全上皮-间质转化细胞中的 Ovol2 表达明显减少（均为 P < 0.01）。结论肿瘤出芽和波形蛋白表达是 T1-2N0 舌鳞癌晚期结节转移的危险因素。Ovol2可能参与了上皮-间质转化的早期阶段。对这些因素进行评估可能会发现哪些患者容易发生晚期结节转移，需要进行选择性颈部切除术。

{"title":"Tumor budding and complete epithelial mesenchymal transition correlate with late nodal metastasis in early-stage tongue squamous cell carcinoma","authors":"Takayoshi Kikuchi , Kinue Kurihara , Homare Kawachi , Satoru Ogane , Kazuhiko Hashimoto , Takahiko Shibahara , Takeshi Nomura","doi":"10.1016/j.ajoms.2024.08.012","DOIUrl":"10.1016/j.ajoms.2024.08.012","url":null,"abstract":"<div><h3>Background</h3><div>Late nodal metastasis is a poor prognostic factor for early-stage tongue squamous cell carcinoma. However, for most early-stage patients, there is a low risk for late nodal metastasis, which currently lacks a diagnostic marker. Tumor budding is a nodal metastasis risk factor in other human cancers. Here, we evaluated tumor budding by partial or complete epithelial-mesenchymal transition and Ovol2 expression, a transcription factor that directly suppresses epithelial-mesenchymal transition.</div></div><div><h3>Methods</h3><div>Sixty-six T1–2N0 patients were enrolled in this retrospective study. Tumor expressions of E-cadherin and vimentin (epithelial-mesenchymal transition markers) and Ovol2 were assessed by immunohistochemistry. Tumor histopathological and immunohistochemical features, mode of invasion, and tumor budding were assessed. Correlations between these potential predictive factors and late nodal metastasis were determined statistically.</div></div><div><h3>Results</h3><div>Univariate analysis demonstrated lymphoid infiltrate, perineural invasion, infiltrative growth pattern, tumor budding, vimentin positive, and complete epithelial-mesenchymal transition were significant factors of late nodal metastasis (all P < 0.05), observed in 25.8 % of patients. Multivariate analysis identified tumor budding and vimentin positive were independent prognostic factors (both P < 0.025). Ovol2 expression was significantly decreased in partial and complete epithelial-mesenchymal transition cells (both P < 0.01) compared with normal epithelia. Univariate analysis, but not multivariate analysis, showed Ovol2 correlated with depth of invasion and tumor budding (both P < 0.05).</div></div><div><h3>Conclusion</h3><div>Tumor budding and vimentin expression are risk factors for late nodal metastasis in T1–2N0 tongue squamous cell carcinoma. Ovol2 might be involved in the early stages of epithelial-mesenchymal transition. Evaluation of these factors might identify patients susceptible to late nodal metastasis who require elective neck dissection.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 1","pages":"Pages 201-209"},"PeriodicalIF":0.4,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142660441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of mantle cell lymphoma (MCL) detected with initial symptoms in the oral region

IF 0.4 Q4 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Oral and Maxillofacial Surgery Medicine and Pathology

Pub Date : 2024-08-26 DOI: 10.1016/j.ajoms.2024.08.016

Shingo Hara, Shohei Domae, Hideka Kanemoto, Yoshihisa Tateishi, Yukihiro Tatemoto

We encountered a case of mantle cell lymphoma (MCL) located in the oral cavity, diagnosed through the analysis of a biopsy sample from a palatal mass. The patient was an 85-year-old female who was referred to our department due to a palatal mass. Contrast-enhanced computed tomography (CT) showed a shadow of a mass in the palate and several enlarged lymph nodes on both sides of the neck. Magnetic resonance imaging revealed diffuse enlargement of the palatal soft tissue, with a faint and uniform signal on T2-weighted imaging. The signal was markedly hyperintense on diffusion-weighted imaging, with multiple lymph node enlargements in the bilateral parotid glands, neck, submental area, and clavicular fossa. Histopathological findings showed dense infiltration of small lymphocyte-like tumor cells beneath the epithelium. Immunostaining was positive for CD20, CD5, and cyclinD1, confirming the diagnosis of MCL. Fluorescence in situ hybridization using a bone marrow aspirate showed positive BCL translocation and negative p53 deletion. Positron emission tomography-CT indicated higher fluorine-18-deoxyglucose accumulation in the palate, as well as in the bilateral cervical, axillary, mesenteric, iliac, and enlarged inguinal lymph nodes, compared to the liver. The Lugano classification was advanced Stage IV, and the patient underwent six courses of combination therapy of bendamustine and rituximab, resulting in complete remission.

{"title":"A case of mantle cell lymphoma (MCL) detected with initial symptoms in the oral region","authors":"Shingo Hara, Shohei Domae, Hideka Kanemoto, Yoshihisa Tateishi, Yukihiro Tatemoto","doi":"10.1016/j.ajoms.2024.08.016","DOIUrl":"10.1016/j.ajoms.2024.08.016","url":null,"abstract":"<div><div>We encountered a case of mantle cell lymphoma (MCL) located in the oral cavity, diagnosed through the analysis of a biopsy sample from a palatal mass. The patient was an 85-year-old female who was referred to our department due to a palatal mass. Contrast-enhanced computed tomography (CT) showed a shadow of a mass in the palate and several enlarged lymph nodes on both sides of the neck. Magnetic resonance imaging revealed diffuse enlargement of the palatal soft tissue, with a faint and uniform signal on T2-weighted imaging. The signal was markedly hyperintense on diffusion-weighted imaging, with multiple lymph node enlargements in the bilateral parotid glands, neck, submental area, and clavicular fossa. Histopathological findings showed dense infiltration of small lymphocyte-like tumor cells beneath the epithelium. Immunostaining was positive for CD20, CD5, and cyclinD1, confirming the diagnosis of MCL. Fluorescence in situ hybridization using a bone marrow aspirate showed positive BCL translocation and negative p53 deletion. Positron emission tomography-CT indicated higher fluorine-18-deoxyglucose accumulation in the palate, as well as in the bilateral cervical, axillary, mesenteric, iliac, and enlarged inguinal lymph nodes, compared to the liver. The Lugano classification was advanced Stage IV, and the patient underwent six courses of combination therapy of bendamustine and rituximab, resulting in complete remission.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 2","pages":"Pages 323-330"},"PeriodicalIF":0.4,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143150325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunohistochemical assessment of stem cell-related Sox2 and Klf4 in ameloblastomas 对骨髓母细胞瘤中干细胞相关的 Sox2 和 Klf4 进行免疫组化评估

IF 0.4 Q4 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Oral and Maxillofacial Surgery Medicine and Pathology

Pub Date : 2024-08-22 DOI: 10.1016/j.ajoms.2024.08.014

Kanako Kuroda , Atsumu Kouketsu , Haruka Saito , Tetsu Takahashi , Kensuke Yamauchi , Tsuyoshi Sugiura , Hiroyuki Kumamoto

Purpose

We aimed to investigate the potential roles of sex-determining region Y-related high mobility group-box 2 (Sox2) and Krüppel-like factor 4 (Klf4), two stem cell-related molecules, in odontogenic tissues.

Methods

Immunohistochemical reactivity to Sox2 and Klf4 was examined in 10 dental follicle and 54 ameloblastoma specimens. The association between these molecules and clinical variables was analyzed in ameloblastoma cases.

Results

Dental follicles showed immunoreactivity to Sox2 and Klf4 predominantly in the dental lamina. In ameloblastomas, Sox2 and Klf4 expression was detected in 48 of the 54 cases, and was predominantly localized in neoplastic cells adjacent to the basement membrane. Sox2 showed substantially higher expression in dental follicles than in ameloblastomas. Granular cell ameloblastomas presented lower levels of Sox2 and Klf4 than acanthomatous ameloblastomas. Moreover, immunoreactivity of ameloblastomas to Sox2 and Klf4 was slightly higher in recurrent cases than in non-recurrent cases.

Conclusions

The differential expression patterns of Sox2 and Klf4 in dental follicles and ameloblastomas indicate that these transcription factors may be involved in the regulation of odontogenic tissues. As these transcription factors are associated with cell proliferation and differentiation in the odontogenic epithelium, they may contribute to tumorigenesis or disease prognosis.

目的我们旨在研究性决定区Y相关高迁移率组盒2（Sox2）和类克鲁珀因子4（Klf4）这两种干细胞相关分子在牙源性组织中的潜在作用。结果在牙槽骨瘤病例中，Sox2 和 Klf4 的免疫反应主要出现在牙层。在 54 例牙釉质母细胞瘤中，有 48 例检测到 Sox2 和 Klf4 的表达，并且主要定位于邻近基底膜的肿瘤细胞。Sox2在牙泡中的表达量远高于在成釉细胞瘤中的表达量。粒细胞性母细胞瘤的 Sox2 和 Klf4 水平低于棘细胞性母细胞瘤。结论 Sox2 和 Klf4 在牙泡和成釉细胞瘤中的不同表达模式表明，这些转录因子可能参与了牙源性组织的调控。由于这些转录因子与牙源性上皮细胞的增殖和分化有关，它们可能有助于肿瘤的发生或疾病的预后。

{"title":"Immunohistochemical assessment of stem cell-related Sox2 and Klf4 in ameloblastomas","authors":"Kanako Kuroda , Atsumu Kouketsu , Haruka Saito , Tetsu Takahashi , Kensuke Yamauchi , Tsuyoshi Sugiura , Hiroyuki Kumamoto","doi":"10.1016/j.ajoms.2024.08.014","DOIUrl":"10.1016/j.ajoms.2024.08.014","url":null,"abstract":"<div><h3>Purpose</h3><div>We aimed to investigate the potential roles of sex-determining region Y-related high mobility group-box 2 (Sox2) and Krüppel-like factor 4 (Klf4), two stem cell-related molecules, in odontogenic tissues.</div></div><div><h3>Methods</h3><div>Immunohistochemical reactivity to Sox2 and Klf4 was examined in 10 dental follicle and 54 ameloblastoma specimens. The association between these molecules and clinical variables was analyzed in ameloblastoma cases.</div></div><div><h3>Results</h3><div>Dental follicles showed immunoreactivity to Sox2 and Klf4 predominantly in the dental lamina. In ameloblastomas, Sox2 and Klf4 expression was detected in 48 of the 54 cases, and was predominantly localized in neoplastic cells adjacent to the basement membrane. Sox2 showed substantially higher expression in dental follicles than in ameloblastomas. Granular cell ameloblastomas presented lower levels of Sox2 and Klf4 than acanthomatous ameloblastomas. Moreover, immunoreactivity of ameloblastomas to Sox2 and Klf4 was slightly higher in recurrent cases than in non-recurrent cases.</div></div><div><h3>Conclusions</h3><div>The differential expression patterns of Sox2 and Klf4 in dental follicles and ameloblastomas indicate that these transcription factors may be involved in the regulation of odontogenic tissues. As these transcription factors are associated with cell proliferation and differentiation in the odontogenic epithelium, they may contribute to tumorigenesis or disease prognosis.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 1","pages":"Pages 228-233"},"PeriodicalIF":0.4,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142660611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0