Journal of Oral and Maxillofacial Surgery Medicine and Pathology最新文献

Clinical and diagnostic features of salivary glands disease related to COVID-19 infection: A systematic review of the literature 与COVID-19感染相关的唾液腺疾病的临床和诊断特征：文献系统回顾

IF 0.4 Q4 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Oral and Maxillofacial Surgery Medicine and Pathology

Pub Date : 2024-09-07 DOI: 10.1016/j.ajoms.2024.08.011

Pierre Guarino , Francesco Chiari , Claudio Donadio Caporale , Livio Presutti , Gabriele Molteni

Purpose

Coronavirus disease 2019 (COVID-19) results from primary infection by severe acute respiratory syndrome coronavirus 2 (Sars COV-2). The transmission thereof is based on mucosal inoculation of infected droplets or direct contact from carriers. However, coronavirus viral loads can be found in throat wash and saliva specimens. The aim of this work is to make an overview about clinical and diagnostic information of patients affected by sialadenitis related to Sars COV-2 infection.

Methods

A systematic literature review has been performed following PRISMA 2020 checklist statement. A computerized search has been carried on by an extensive set of queries on the Embase/Pubmed, Scopus and Cochrane databases, relating to articles published from January 2020 to February 2024.

Results

Information reported within ten papers has been processed in this review. The total amount of patients included was 27 (55 % females), with a mean age of 35.6 years. All patients showed a parotid gland infection, which was described bilaterally in 45 % of cases. However, submandibular and sublingual gland infections were reported only as of a single patient. Sialadenitis diagnosis was made through clinical examination, radiological tools and laboratory tests. The diagnosis of parotitis was contextual or delayed to COVID-19 detection in 78 % and 22 % of cases, respectively. The therapeutic management thereof consisted of symptomatic therapies as in Sars COV-2 infection. Antibiotics were reserved in a few cases (12 %).

Conclusions

Sialadenitis in patients affected by Sars COV-2 is an uncommon manifestation of COVID-19 infection. Its treatment and prognosis do not differ from those used to treat patients affected by Sars COV-2.

目的 2019 年冠状病毒病（COVID-19）是由严重急性呼吸系统综合征冠状病毒 2（Sars COV-2）原发感染引起的。其传播途径是通过粘膜接种受感染的飞沫或直接接触带毒者。然而，冠状病毒病毒载量可在咽喉洗液和唾液标本中发现。本文旨在概述与萨斯COV-2感染相关的唾液腺炎患者的临床和诊断信息。通过在 Embase/Pubmed、Scopus 和 Cochrane 数据库中进行大量查询，对 2020 年 1 月至 2024 年 2 月期间发表的相关文章进行了计算机检索。共纳入 27 名患者（55% 为女性），平均年龄为 35.6 岁。所有患者均表现为腮腺感染，45%的病例为双侧感染。然而，仅有一名患者报告了颌下腺和舌下腺感染。腮腺炎症的诊断是通过临床检查、放射学工具和实验室检测做出的。78% 和 22% 的腮腺炎诊断与 COVID-19 检测相关或延迟。其治疗方法与萨斯COV-2感染一样，包括对症治疗。结论Sars COV-2感染者的咽鼓管炎是COVID-19感染的一种不常见表现。其治疗方法和预后与治疗 Sars COV-2 患者的方法并无不同。

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引用次数: 0

Tube feeding in patients with head and neck cancer undergoing chemoradio-/radio therapy: A systematic review and meta-analysis based on the GRADE approach 接受化疗/放疗的头颈部癌症患者的管饲：基于GRADE方法的系统综述和荟萃分析

IF 0.4 Q4 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Oral and Maxillofacial Surgery Medicine and Pathology

Pub Date : 2024-08-30 DOI: 10.1016/j.ajoms.2024.08.015

Taiki Suzuki , Souichi Yanamoto , Daisuke Takeda , Hirokazu Saito , Haruki Sato , Seiji Asoda , Masatoshi Adachi , Hidemichi Yuasa , Narikazu Uzawa , Hiroshi Kurita

Scope

The scope of this systematic review (SR) was to determine whether a nasogastric tube (NGT) or percutaneous endoscopic gastrostomy (PEG) is a more useful supportive therapy in patients with oral cancer undergoing chemoradio-/radio therapy.

Methods

For the review, two authors searched MEDLINE, Cochrane CENTRAL and Ichushi-Web to identify clinical practice guidelines, SRs and randomised controlled trials (RCTs) according to pre-determined criteria. RevMan Web was used to combine trials and analyse the data. We evaluated the certainty of the evidence using the Grading of Recommendations, Assessment, Development and Evaluation system approach.

Results

It was not possible to perform a meta-analysis of only treatment completion based on the included RCTs; therefore, we performed a meta-analysis of treatment breaks as a surrogate outcome. A meta-analysis of potential treatment breaks, including treatment discontinuation, revealed no superiority between PEG and NGT (risk ratio=0.64 [0.23, 1.79]). A meta-analysis was conducted on two RCTs regarding the harms of infection. There does not appear to be a significant increase in the risk of infection with either PEG or NGT (risk ratio=1.18 [0.45, 3.08]). The certainty of the evidence for two outcomes was judged to be very low. Further, meta-analyses of quality of life and nutritional status were not possible because of differences in assessment methods.

Conclusion

We could not determine the superiority of NGT or PEG in the supportive care of oral cancer patients who received chemoradio-/radio therapy. The effect of PEG feeding is uncertain, and it is necessary to consider indications for each case.

范围本系统综述（SR）的范围是确定对于接受化疗/放疗的口腔癌患者，鼻胃管 (NGT) 还是经皮内镜胃造瘘术 (PEG) 是一种更有用的支持疗法。方法在综述中，两位作者按照预先确定的标准检索了 MEDLINE、Cochrane CENTRAL 和 Ichushi-Web 以确定临床实践指南、SR 和随机对照试验 (RCT)。RevMan Web 用于合并试验和分析数据。我们采用推荐、评估、发展和评价系统分级法对证据的确定性进行了评估。结果根据纳入的随机对照试验，我们无法仅对治疗完成情况进行荟萃分析；因此，我们对治疗中断作为替代结果进行了荟萃分析。对包括治疗中断在内的潜在治疗中断进行的荟萃分析表明，PEG 和 NGT 之间没有优劣之分（风险比=0.64 [0.23, 1.79]）。对两项研究性试验进行了有关感染危害的荟萃分析。无论是 PEG 还是 NGT，感染风险似乎都没有显著增加（风险比=1.18 [0.45, 3.08]）。两项结果的证据确定性被认为很低。此外，由于评估方法不同，无法对生活质量和营养状况进行荟萃分析。结论我们无法确定 NGT 或 PEG 在对接受化疗/放疗的口腔癌患者进行支持性护理方面的优越性。PEG喂养的效果尚不确定，有必要考虑每个病例的适应症。

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引用次数: 0

Tumor budding and complete epithelial mesenchymal transition correlate with late nodal metastasis in early-stage tongue squamous cell carcinoma 肿瘤出芽和完全上皮间质转化与早期舌鳞状细胞癌晚期结节转移有关

IF 0.4 Q4 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Oral and Maxillofacial Surgery Medicine and Pathology

Pub Date : 2024-08-30 DOI: 10.1016/j.ajoms.2024.08.012

Takayoshi Kikuchi , Kinue Kurihara , Homare Kawachi , Satoru Ogane , Kazuhiko Hashimoto , Takahiko Shibahara , Takeshi Nomura

Background

Late nodal metastasis is a poor prognostic factor for early-stage tongue squamous cell carcinoma. However, for most early-stage patients, there is a low risk for late nodal metastasis, which currently lacks a diagnostic marker. Tumor budding is a nodal metastasis risk factor in other human cancers. Here, we evaluated tumor budding by partial or complete epithelial-mesenchymal transition and Ovol2 expression, a transcription factor that directly suppresses epithelial-mesenchymal transition.

Methods

Sixty-six T1–2N0 patients were enrolled in this retrospective study. Tumor expressions of E-cadherin and vimentin (epithelial-mesenchymal transition markers) and Ovol2 were assessed by immunohistochemistry. Tumor histopathological and immunohistochemical features, mode of invasion, and tumor budding were assessed. Correlations between these potential predictive factors and late nodal metastasis were determined statistically.

Results

Univariate analysis demonstrated lymphoid infiltrate, perineural invasion, infiltrative growth pattern, tumor budding, vimentin positive, and complete epithelial-mesenchymal transition were significant factors of late nodal metastasis (all P < 0.05), observed in 25.8 % of patients. Multivariate analysis identified tumor budding and vimentin positive were independent prognostic factors (both P < 0.025). Ovol2 expression was significantly decreased in partial and complete epithelial-mesenchymal transition cells (both P < 0.01) compared with normal epithelia. Univariate analysis, but not multivariate analysis, showed Ovol2 correlated with depth of invasion and tumor budding (both P < 0.05).

Conclusion

Tumor budding and vimentin expression are risk factors for late nodal metastasis in T1–2N0 tongue squamous cell carcinoma. Ovol2 might be involved in the early stages of epithelial-mesenchymal transition. Evaluation of these factors might identify patients susceptible to late nodal metastasis who require elective neck dissection.

背景晚期结节转移是早期舌鳞状细胞癌的一个不良预后因素。然而，对于大多数早期患者来说，晚期结节转移的风险较低，目前缺乏诊断标志物。肿瘤萌芽是其他人类癌症的结节转移风险因素。在此，我们通过部分或完全的上皮-间质转化和Ovol2（一种直接抑制上皮-间质转化的转录因子）的表达来评估肿瘤萌芽。免疫组化法评估了肿瘤中E-cadherin和vimentin（上皮-间质转化标志物）以及Ovol2的表达。对肿瘤组织病理学和免疫组化特征、侵袭方式和肿瘤出芽进行了评估。结果单变量分析表明，淋巴细胞浸润、神经周围浸润、浸润生长模式、肿瘤出芽、波形蛋白阳性和完全上皮-间质转化是晚期结节转移的重要因素（均为 P < 0.05），在 25.8% 的患者中观察到。多变量分析发现，肿瘤出芽和波形蛋白阳性是独立的预后因素（均为 P < 0.025）。与正常上皮细胞相比，部分上皮-间质转化细胞和完全上皮-间质转化细胞中的 Ovol2 表达明显减少（均为 P < 0.01）。结论肿瘤出芽和波形蛋白表达是 T1-2N0 舌鳞癌晚期结节转移的危险因素。Ovol2可能参与了上皮-间质转化的早期阶段。对这些因素进行评估可能会发现哪些患者容易发生晚期结节转移，需要进行选择性颈部切除术。

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引用次数: 0

Immunohistochemical assessment of stem cell-related Sox2 and Klf4 in ameloblastomas 对骨髓母细胞瘤中干细胞相关的 Sox2 和 Klf4 进行免疫组化评估

IF 0.4 Q4 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Oral and Maxillofacial Surgery Medicine and Pathology

Pub Date : 2024-08-22 DOI: 10.1016/j.ajoms.2024.08.014

Kanako Kuroda , Atsumu Kouketsu , Haruka Saito , Tetsu Takahashi , Kensuke Yamauchi , Tsuyoshi Sugiura , Hiroyuki Kumamoto

Purpose

We aimed to investigate the potential roles of sex-determining region Y-related high mobility group-box 2 (Sox2) and Krüppel-like factor 4 (Klf4), two stem cell-related molecules, in odontogenic tissues.

Methods

Immunohistochemical reactivity to Sox2 and Klf4 was examined in 10 dental follicle and 54 ameloblastoma specimens. The association between these molecules and clinical variables was analyzed in ameloblastoma cases.

Results

Dental follicles showed immunoreactivity to Sox2 and Klf4 predominantly in the dental lamina. In ameloblastomas, Sox2 and Klf4 expression was detected in 48 of the 54 cases, and was predominantly localized in neoplastic cells adjacent to the basement membrane. Sox2 showed substantially higher expression in dental follicles than in ameloblastomas. Granular cell ameloblastomas presented lower levels of Sox2 and Klf4 than acanthomatous ameloblastomas. Moreover, immunoreactivity of ameloblastomas to Sox2 and Klf4 was slightly higher in recurrent cases than in non-recurrent cases.

Conclusions

The differential expression patterns of Sox2 and Klf4 in dental follicles and ameloblastomas indicate that these transcription factors may be involved in the regulation of odontogenic tissues. As these transcription factors are associated with cell proliferation and differentiation in the odontogenic epithelium, they may contribute to tumorigenesis or disease prognosis.

目的我们旨在研究性决定区Y相关高迁移率组盒2（Sox2）和类克鲁珀因子4（Klf4）这两种干细胞相关分子在牙源性组织中的潜在作用。结果在牙槽骨瘤病例中，Sox2 和 Klf4 的免疫反应主要出现在牙层。在 54 例牙釉质母细胞瘤中，有 48 例检测到 Sox2 和 Klf4 的表达，并且主要定位于邻近基底膜的肿瘤细胞。Sox2在牙泡中的表达量远高于在成釉细胞瘤中的表达量。粒细胞性母细胞瘤的 Sox2 和 Klf4 水平低于棘细胞性母细胞瘤。结论 Sox2 和 Klf4 在牙泡和成釉细胞瘤中的不同表达模式表明，这些转录因子可能参与了牙源性组织的调控。由于这些转录因子与牙源性上皮细胞的增殖和分化有关，它们可能有助于肿瘤的发生或疾病的预后。

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引用次数: 0

The evaluation of pathologic fracture risk and residual bone height in unicortical and bicortical mandibular corpus defects: A 3D finite analysis 评估单皮质和双皮质下颌骨冠状缺损的病理性骨折风险和残余骨高度：三维有限元分析

IF 0.4 Q4 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Oral and Maxillofacial Surgery Medicine and Pathology

Pub Date : 2024-08-16 DOI: 10.1016/j.ajoms.2024.08.013

Arzum Yilmaz , Sedat Çeti̇ner , Ilgin Ari

Objective

Mandibular bone defects are a common problem and difficult to manage. A defected area mostly left to heal spontaneously. It doesn’t have a definite protocol in the literature, when the area will be left to heal spontaneously or when supported with materials such as plates, screws, grafts, especially in intermediate-sized defects. In this study, it was aimed to determine by examining the areas where the stresses due to chewing forces are concentrated on the mandible bone and the risk of fracture in intermediate size unicortical and bicortical defects.

Material and Methods

The all defect models which was the residual bone heights were 6, 8, 10 mm in mandibular corpus region were created. Two different loading scenarios were applied anterior and defected premolar side. Von Mises, Pmax and Pmin stresses in models were evaluated by three-dimensional finite element analysis method.

Results

The study found higher stress accumulation on the buccal anterior side of defects in both unicortical and bicortical models, with the most stress concentrated at the buccal corners. Under Loading 1, bicortical defects with 10 mm residual bone height showed slightly higher stress accumulations than unicortical defects, while bicortical defects with 8 and 6 mm residual bone height exhibited significantly higher stress values. Under Loading 2, stress accumulations in bicortical defects were higher than in unicortical defects, with bicortical defects at 6 mm residual bone height showing almost double the stress values. Pmax stress values were higher in bicortical defects under both loadings, especially when the residual bone height decreased. Pmin stress values were comparable in unicortical defects but were higher in bicortical defects, particularly at 6 mm residual bone height, under both loading conditions.

Conclusion

This study was presented that mandibular resistance decreases significantly when residual bone height is less than 10 mm for bicortical defects and less than 8 mm at unicortical defects. In these conditions it may need supported with materials to prevent fractures. However, in vivo and in vitro studies are necessary for definitive conclusions.

目的下颌骨缺损是一个常见的问题，也是一个难以处理的问题。缺损区域大多会自行愈合。文献中并没有明确的方案说明何时让缺损区域自发愈合，或使用钢板、螺钉、移植物等材料进行支撑，尤其是对于中等大小的缺损。本研究旨在通过检查咀嚼力导致的应力集中在下颌骨的哪些部位，以及中等大小的单皮质和双皮质缺损发生骨折的风险。在前磨牙前侧和前磨牙缺损侧应用了两种不同的加载情况。结果研究发现，在单皮质和双皮质模型中，缺损的颊前侧都有较高的应力累积，最大的应力集中在颊角。在加载 1 条件下，残余骨高度为 10 毫米的双皮质缺损的应力累积略高于单皮质缺损，而残余骨高度为 8 毫米和 6 毫米的双皮质缺损的应力值明显更高。在加载 2 条件下，双皮质缺损的应力累积高于单皮质缺损，残余骨高度为 6 毫米的双皮质缺损的应力值几乎是单皮质缺损的两倍。在两种载荷下，双皮质缺损的 Pmax 应力值都较高，尤其是当残余骨高度降低时。在两种加载条件下，单皮质缺损的 Pmin 应力值相当，但双皮质缺损的 Pmin 应力值更高，尤其是在残余骨高度为 6 毫米时。在这种情况下，可能需要用材料支撑以防止骨折。不过，要得出明确的结论，还需要进行体内和体外研究。

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引用次数: 0

Investigation of periodontal tissue regeneration using octacalcium phosphate and collagen composite 使用磷酸八钙和胶原蛋白复合材料进行牙周组织再生的研究

IF 0.4 Q4 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Oral and Maxillofacial Surgery Medicine and Pathology

Pub Date : 2024-08-16 DOI: 10.1016/j.ajoms.2024.08.009

Keiko Matsui , Shinji Kamakura , Atsumu Kouketsu , Yushi Ezoe , Kei-ichiro Miura , Kensuke Yamauchi

Objective

This study aimed to investigate periodontal tissue regenerative potential of octacalcium phosphate (OCP) and collagen composite (OCPcol), recognized as excellent bone-regenerative materials, in artificial bone defect models using beagle dogs. This study specifically assessed the efficacy of OCPcol in periodontal soft-tissue regeneration.

Methods

OCPcol was implanted in bone defects adjacent to the roots of the left mandibular third and fourth premolars in six beagle dogs (OCP group), while five dogs did not receive OCPcol (control group). The dogs were observed for 3 months. The specimens were evaluated radiologically and histologically.

Results

Microcomputed tomography revealed bone regeneration originating from the lateral cortical bone surface adjacent to the created defect. The superficial layer of the regenerated bone was cortical bone-like and continuous with the upper and lower alveolar bone. The bone was regenerated by maintaining a continuous void in the periodontal ligament space above and below the dentinal defect. Dental defects of roots were not regenerated. The control group did not exhibit sufficient bone regeneration. Histologically, in the OCP group, formation of new cementum was observed on the outer surface of the root dentin, with connective tissue attachment and an oblique-running periodontal ligament in the space between the new bone and dentin. However, the dentinal defects were not regenerated．

Conclusions

Alveolar bone and periodontal ligament regenerated when OCPcol was implanted into a bone and dentinal defect created around a natural tooth root. These results suggest that OCPcol effectively regenerates periodontal tissue, without ankylosis.

目的本研究旨在使用小猎犬在人工骨缺损模型中研究磷酸八钙（OCP）和胶原复合材料（OCPcol）的牙周组织再生潜力。本研究特别评估了 OCPcol 在牙周软组织再生中的功效。方法将 OCPcol 植入六只小猎犬（OCP 组）左下颌第三和第四前臼齿根部附近的骨缺损处，而五只小猎犬未接受 OCPcol（对照组）。对这些狗进行了为期 3 个月的观察。结果微计算机断层扫描显示，骨再生源于邻近缺损处的外侧皮质骨表面。再生骨的表层呈皮质骨样，与上下牙槽骨连续。通过在牙本质缺损上下的牙周韧带间隙中保持连续的空隙，实现了牙槽骨的再生。牙根缺损没有再生。对照组没有表现出足够的骨再生。从组织学角度看，OCP 组观察到牙根牙本质外表面形成了新的骨水泥，新骨和牙本质之间的空隙中有结缔组织附着和斜行牙周韧带。结论将 OCPcol 植入天然牙根周围的牙槽骨和牙本质缺损处后，牙槽骨和牙周韧带得以再生。这些结果表明，OCPcol 能有效地使牙周组织再生，而不会发生强直。

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引用次数: 0

Using texture analysis of ultrasonography images of neck lymph nodes to differentiate metastasis to non-metastasis in oral maxillary gingival squamous cell carcinoma 利用颈部淋巴结超声图像的纹理分析区分口腔上颌龈鳞癌的转移与非转移

IF 0.4 Q4 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Oral and Maxillofacial Surgery Medicine and Pathology

Pub Date : 2024-08-10 DOI: 10.1016/j.ajoms.2024.07.013

Yusuke Kawashima , Aya Hagimoto , Hiroshi Abe , Masaaki Miyakoshi , Yoshihiro Kawabata , Hiroko Indo , Tatsurou Tanaka

Object

To differentiate between metastatic neck nodes and non-metastatic neck nodes in oral maxillary gingival squamous cell carcinoma, textural analysis of these lymph nodes in ultrasound images was performed in this study.

Methods

Twenty five metastatic neck nodes and 28 non-metastatic neck nodes were enrolled in this study. Seventy eight texture characteristics were retrieved from the US images using the LIFEx software.

The Mann Whitney U test was measurably utilized to survey on the off chance that there was a measurably noteworthy distinction within the textural characteristics between metastatic neck nodes and non-metastatic neck nodes. The capacity of the surface highlights to recognize between metastatic neck nodes and non-metastatic neck nodes was illustrated utilizing the Receiver Operating Characteristic analysis curves (ROC). Youden's J statistic was used to determine the cut-off positions in each ROC curve that maximized sensitivity and specificity.

Results

Zone size non uniformity (ZSNU) highlight appeared the foremost noteworthy contrast between these nodes (p < 0.001).

Strength had Area Under the Curve (AUC) of 0.811, specificity of 0.821 and sensitivity of 0.8, when measured at the cutoff value of 896.344.

Conclusions

Our results come about uncovered that quality highlight may be the finest surface highlight to distinguish from non-metastatic neck nodes and to anticipate metastatic neck nodes in oral maxillary gingival squamous cell carcinoma.

为了区分口腔上颌牙龈鳞状细胞癌的转移性颈部淋巴结和非转移性颈部淋巴结，本研究对这些淋巴结的超声图像进行了纹理分析。使用 LIFEx 软件从超声图像中提取了 78 个纹理特征。采用 Mann Whitney U 检验来调查转移性颈部结节和非转移性颈部结节的纹理特征是否存在显著差异。利用接收者操作特性分析曲线（ROC）说明了表面亮点识别转移性颈部结节和非转移性颈部结节的能力。结果Zone size non uniformity (ZSNU) 高亮显示出这些结节之间最显著的对比（p < 0.001），强度曲线下面积（AUC）为 0.811，特异性为 0.结论我们的研究结果发现，质量高亮度可能是区分非转移性颈部结节和预测口腔上颌龈鳞癌转移性颈部结节的最佳表面高亮度。

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引用次数: 0

Comparison of Lefort-1 advancement by internal and external distraction osteogenesis in non-syndromic cleft lip and palate: A systematic review and meta-analysis 非综合征唇腭裂患者通过内外牵引成骨法进行 Lefort-1 推进的比较：系统回顾和荟萃分析

IF 0.4 Q4 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Oral and Maxillofacial Surgery Medicine and Pathology

Pub Date : 2024-08-03 DOI: 10.1016/j.ajoms.2024.08.002

Sameer Pandey , Ashi Chug , Srinivas Gosla Reddy , Saurabh S. Simre

Purpose

In 25 % of Cleft lip and palate (CLP) patients, midface hypoplasia (MH) is non-responsive to orthodontics. Post-surgical scarring in cleft patients causes large relapse with conventional osteotomies. Distraction osteogenesis (DO) has become the choice of treatment for midface hypoplasia in CLP patient. The systematic review aims to generate evidence to guide the selection of distraction devices for non-syndromic CLP associated maxillary hypoplasia.

Materials and methods

A PRISMA-guided systematic review was planned. Studies with LeFort 1 distraction osteogenesis in non-syndromic CLP patients were included. Four literature databases (PubMed, Embase, Cochrane and Ovid) were searched. Identified studies were shortlisted based on PICOS criteria for data extraction. SNA, SNB and ANB angle measurements were extracted pre-distraction and within 1 year and after 1-year post-distraction. Forest plots were generated to understand the maxillary advancement and relapse associated with external and internal distractor. Risk of bias was evaluated for non-randomized studies and a traffic light plot as well as summary plot was generated for inference.

Results

A total of 2395 articles were identified after a database search. 131 articles were included for full-text review and 31 articles were selected for data synthesis. A total of 361 patients underwent distraction osteogenesis, out of which 265 patients underwent external DO, and 96 underwent internal DO. Pooled data analysis revealed a larger increase in SNA angle for external distractors than internal distractors.

Conclusion

External DO provide a greater degree of midface advancement than internal DO. The degree of relapse is more with external distraction.

目的在 25% 的唇腭裂（CLP）患者中，面中部发育不良（MH）对正畸无反应。唇腭裂患者手术后的瘢痕会导致传统截骨术的大量复发。牵引成骨术（DO）已成为治疗CLP患者面中部发育不良的首选方法。本系统综述旨在提供证据，以指导非综合征CLP相关上颌骨发育不良的牵引装置的选择。纳入了针对非综合征CLP患者的LeFort 1牵引成骨的研究。检索了四个文献数据库（PubMed、Embase、Cochrane 和 Ovid）。根据 PICOS 标准对确定的研究进行筛选，以提取数据。提取了牵引前、牵引后 1 年内和 1 年后的 SNA、SNB 和 ANB 角度测量值。生成森林图以了解与外牵引器和内牵引器相关的上颌前突和复发情况。对非随机研究进行了偏倚风险评估，并生成了交通灯图和摘要图以进行推断。131篇文章被纳入全文综述，31篇文章被选中进行数据综合。共有 361 名患者接受了牵张成骨术，其中 265 名患者接受了外牵张成骨术，96 名患者接受了内牵张成骨术。综合数据分析显示，外侧牵引比内侧牵引的 SNA 角度增加更大。外部牵引的复发率更高。

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引用次数: 0

Examination of the duration of vitamin B12 administration for hypoesthesia caused by inferior alveolar nerve injury after horizontally impacted mandibular third molar: A retrospective study 研究下颌第三磨牙水平撞击后下牙槽神经损伤引起的低痛症服用维生素B12的持续时间：回顾性研究

IF 0.4 Q4 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Oral and Maxillofacial Surgery Medicine and Pathology

Pub Date : 2024-08-02 DOI: 10.1016/j.ajoms.2024.07.010

Takumi Shimura, Ken-ichiro Sakata, Hiroyuki Hato, Haruhisa Watanabe, Takuya Asaka, Jun Sato, Yoshimasa Kitagawa

Objective

This study aimed to assess the time to cure of hypoesthesia caused by inferior alveolar nerve (IAN) injury after horizontally impacted mandibular third molar (M3) extraction under continuous administration of mecobalamin, a vitamin B12 preparation, and factors that influence the time to cure.

Methods

This was a single-center retrospective study including 33 patients who experienced hypoesthesia after horizontally impacted M3 extraction and were treated with continuous oral administration of mecobalamin alone. The patients were divided into cured (n = 28) and uncured groups (n = 5). Demographic and clinical data were collected and analyzed.

Results

Of the 33 patients, 5 (15 %) reported uncured hypoesthesia. The median time to cure of hypoesthesia with mecobalamin administration was 33 (range, 6–202) days, and no cure beyond 7 months was reported. Age (≥30 years), Pell and Gregory classification (Position), and presence of Rood and Shehab signs ("interruption of white line of canal" and "diversion of canal") were significantly associated with prolonged time to cure.

Conclusions

It may be necessary to evaluate the efficacy of mecobalamin for IAN injury after horizontally impacted M3 extraction approximately 30 days after the initiation of administration and consider treatment modification or additional treatment within approximately 7 months.

本研究旨在评估下颌第三磨牙（M3）水平撞击拔除术后，在持续服用维生素 B12 制剂甲钴胺的情况下，下牙槽神经（IAN）损伤引起的低麻痹的治愈时间，以及影响治愈时间的因素。患者被分为治愈组（28 人）和未治愈组（5 人）。收集并分析了人口统计学和临床数据。服用甲钴胺治愈麻痹的中位时间为 33 天（6-202 天），没有超过 7 个月的治愈报告。年龄（≥30 岁）、Pell 和 Gregory 分级（Position）以及 Rood 和 Shehab 征兆（"管白线中断 "和 "管分流"）的存在与治愈时间的延长有显著相关性。结论可能有必要在开始用药后 30 天左右评估甲钴胺对水平撞击式 M3 拔牙后 IAN 损伤的疗效，并考虑在大约 7 个月内调整治疗方法或进行额外治疗。

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引用次数: 0

Healing of tooth extraction wound socket, do we have current understanding? 拔牙创口的愈合，我们目前了解多少？

IF 0.4 Q4 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Oral and Maxillofacial Surgery Medicine and Pathology

Pub Date : 2024-07-20 DOI: 10.1016/j.ajoms.2024.07.009

Aqsa Kamal , Maryam Kamal , Alina Hasnat , Abeera Mohsin , A.R. Samsudin

Objective

This review paper aims to provide an up to date understanding on tooth socket healing signifying the impact of osteoimmunology, cellular and molecular events, role of nerves, growth factors, signaling pathways, oxygen, endocrine and obesity in healing and regeneration.

Methods

A thorough literature search was conducted using up to date software and electronic databases including Python 3.9.7 and latent Dirichlet allocation (LDA).

Results

70 relevant articles were included. Tooth socket healing is different from other types of bone healing.

Conclusion

Role of osteoimmunology, macrophages, mesenchymal stem cells, growth factors, hormones and nerves in tooth socket healing have been ignored for long. These factors can result in impaired wound healing or disruption the healing process. Understanding the mechanisms involved in tooth socket healing can contribute to the development of targeted strategies for promoting optimal healing outcomes.

方法使用最新的软件和电子数据库，包括Python 3.9.7和潜狄利克特分配（LDA），对文献进行了全面检索。结果共收录了70篇相关文章。结论长期以来，骨免疫学、巨噬细胞、间充质干细胞、生长因子、激素和神经在牙槽骨愈合中的作用一直被忽视。这些因素会导致伤口愈合受损或愈合过程中断。了解牙槽骨愈合的相关机制有助于制定有针对性的策略，促进最佳愈合效果。

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引用次数: 0