Latent Childhood Exposure to Mixtures of Metals and Neurodevelopmental Outcomes in 4–5-Year-Old Children Living in Spain

IF 4.5 3区 环境科学与生态学 Q1 WATER RESOURCES Exposure and Health Pub Date : 2023-10-31 DOI:10.1007/s12403-023-00610-8
L. Notario-Barandiaran, S. Díaz-Coto, N. Jimenez-Redondo, M. Guxens, M. Vrijheid, A. Andiarena, A. Irizar, I. Riaño-Galan, A. Fernández-Somoano, S. Llop, M. Lozano, M. R. Karagas, A. Meharg, M. Carey, C. Meharg, K. Ralphs, C. McCreanor, J. Vioque, P. Martinez-Camblor, A. J. Signes-Pastor
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Abstract

Abstract Neurodevelopmental disorders are increasing globally, and metal exposure may play a significant role as an environmental factor. This cross-sectional study aimed to identify metal mixture patterns and assess their impact on children’s neurodevelopment. Data from 962 children (aged 4–5 years) participating in the Spanish INMA cohort study were analysed. Urinary metal concentrations (cobalt (Co), copper (Cu), molybdenum (Mo), selenium (Se), lead (Pb), zinc (Zn), and arsenic speciation) were used as exposure biomarkers. Principal component analysis (PCA) revealed four latent exposure variables representing uncorrelated metal mixture patterns. Linear regression analyses examined the associations between these variables and children’s neuropsychological functions assessed through the McCarthy Scales of Children’s Abilities. The first latent exposure variable (Cu, Se, Pb, Zn) and the second (inorganic arsenic, monomethylarsonic acid) showed negative associations with verbal executive function ( ß = − 1.88, 95% confidence interval (CI) = − 3.17 to − 0.59) and gross motor function ( ß = − 1.41, 95% CI = − 2.36 to − 0.46), respectively. Conversely, the third variable (Mo, Co) and the fourth (arsenobetaine) exhibited positive associations with visual and verbal span functions ( ß = 1.14, 95% CI = 0.16 to 2.12) and fine motor function ( ß = 1.01, 95% CI = 0.11 to 1.92), respectively. This study suggests that even relatively low levels of metal latent exposures, notably inorganic arsenic and a mixture of metals including Pb, adversely affect children’s neuropsychological development function scores, while exposure to arsenobetaine and a mixture of Co and Mo has a positive impact.
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居住在西班牙的4 - 5岁儿童的潜在儿童接触金属混合物和神经发育结果
神经发育障碍在全球范围内日益增加,金属暴露可能作为一种环境因素发挥重要作用。本横断面研究旨在确定金属混合模式,并评估其对儿童神经发育的影响。分析了962名参加西班牙INMA队列研究的儿童(4-5岁)的数据。尿液金属浓度(钴(Co)、铜(Cu)、钼(Mo)、硒(Se)、铅(Pb)、锌(Zn)和砷形成)被用作暴露生物标志物。主成分分析(PCA)揭示了四个潜在暴露变量代表不相关的金属混合模式。线性回归分析检验了这些变量与通过麦卡锡儿童能力量表评估的儿童神经心理功能之间的联系。第一潜在暴露变量(Cu, Se, Pb, Zn)和第二潜在暴露变量(无机砷,单甲基胂酸)分别与语言执行功能(ß = - 1.88, 95%可信区间(CI) = - 3.17至- 0.59)和大运动功能(ß = - 1.41, 95% CI = - 2.36至- 0.46)呈负相关。相反,第三个变量(Mo, Co)和第四个变量(arsenobetaine)分别与视觉和言语广度功能(ß = 1.14, 95% CI = 0.16 ~ 2.12)和精细运动功能(ß = 1.01, 95% CI = 0.11 ~ 1.92)呈正相关。这项研究表明,即使是相对低水平的金属潜在暴露,特别是无机砷和包括铅在内的金属混合物,也会对儿童的神经心理发育功能评分产生不利影响,而接触砷甜菜碱和Co和Mo的混合物则有积极影响。
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来源期刊
Exposure and Health
Exposure and Health Environmental Science-Pollution
CiteScore
13.80
自引率
9.00%
发文量
71
期刊介绍: It is a multidisciplinary journal focused on global human health consequences of exposure to water pollution in natural and engineered environments. The journal provides a unique platform for scientists in this field to exchange ideas and share information on research for the solution of health effects of exposure to water pollution. Coverage encompasses Engineering sciences; Biogeochemical sciences; Health sciences; Exposure analysis and Epidemiology; Social sciences and public policy; Mathematical, numerical and statistical methods; Experimental, data collection and data analysis methods and more. Research topics include local, regional and global water pollution, exposure and health problems; health risk analysis of water pollution, methods of quantification and analysis of risk under uncertainty; aquatic biogeochemical processes in natural and engineered systems and health effects; analysis of pollution, exposure and health data; and more.
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