Development of Polyherbal Formulation: Impact of Antioxidants on In Vivo Antidepressant Activity in Animal Models

IF 0.4 4区 医学 Q4 PHARMACOLOGY & PHARMACY Indian Journal of Pharmaceutical Sciences Pub Date : 2023-01-01 DOI:10.36468/pharmaceutical-sciences.1188
A. R. Surana, M. R. Kumbhare, H. I. Narkhede
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Abstract

In Ayurveda, single or multiple herbs are used as medication for various ailments. Depression is often manifesting with various symptoms at the behavioral, psychological and physiological levels. Therefore, the investigation for therapeutic alternative is important. Oxidative stress has shown important biochemical aspects in the depression. This study evaluated effect of natural antioxidant on antidepressant activity of polyherbal formulation on the performance of male mice. Mice were given orally polyherbal formulation without antioxidant and with antioxidant daily for 7 d and then subjected to forced swim test and tail suspension test. After 1 w treatment, both polyherbal formulation significantly reduced immobility time in forced swim test and tail suspension test compared with vehicle treated control group. The immobility time in tail suspension test of polyherbal formulation without antioxidant and with antioxidant was found to be 151.17±4.46 s and 116.33±8.84 s respectively. The immobility time in tail suspension test of polyherbal formulation without antioxidant and with antioxidant was found to be 137.17±5.93 s, 113.50±5.40 s respectively. These results indicate that the antidepressant when given along with antioxidant in mice it gives significant antidepressant effect. The experimental results suggest that the intake of antioxidant may help in reducing the symptoms of depression, via supplementation of antioxidant.
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多草药配方的开发:抗氧化剂对动物模型体内抗抑郁活性的影响
在阿育吠陀,单一或多种草药被用作治疗各种疾病的药物。抑郁症往往表现为行为、心理和生理层面的各种症状。因此,研究替代治疗方法是很重要的。氧化应激在抑郁症中表现出重要的生化作用。本研究评价了天然抗氧化剂对复方抗抑郁活性对雄性小鼠生产性能的影响。小鼠每天口服不含抗氧化剂和含抗氧化剂的复方,连续7 d,然后进行强迫游泳试验和悬尾试验。治疗1 w后,与对照组相比,两种复方均显著减少了强迫游泳试验和悬尾试验的静止时间。不加抗氧剂和加抗氧剂的复方尾悬试验的静止时间分别为151.17±4.46 s和116.33±8.84 s。不加抗氧剂和加抗氧剂的复方在尾悬试验中的静止时间分别为137.17±5.93 s和113.50±5.40 s。这些结果表明,抗抑郁药与抗氧化剂一起给予小鼠具有显著的抗抑郁作用。实验结果表明,抗氧化剂的摄入可能有助于减轻抑郁症的症状,通过补充抗氧化剂。
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期刊介绍: The Indian Journal of Pharmaceutical Sciences (IJPS) is a bi-monthly Journal, which publishes original research work that contributes significantly to further the scientific knowledge in Pharmaceutical Sciences (Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy and Phytochemistry, Pharmacology and Therapeutics, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Pharmacovigilance, Pharmacoepidemiology, Pharmacoeconomics, Drug Information, Patient Counselling, Adverse Drug Reactions Monitoring, Medication Errors, Medication Optimization, Medication Therapy Management, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest). The Journal publishes original research work either as a Full Research Paper or as a Short Communication. Review Articles on current topics in Pharmaceutical Sciences are also considered for publication by the Journal.
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