Applications of Proteomics in Human Medicine

Abstract

Technology is used in proteomics to count and estimate how many proteins are present in each cell, tissue, and organism. It aids in the identification of an organism's proteins and the comprehension of the structure and functions of a particular protein, complementing other "omics" technologies like genomics and transcriptomics. Proteomics is fundamentally complicated because it entails categorizing and examining all of the protein signatures in a genome. Mass spectrometry is the foundation of contemporary proteomics, with LC-MS-MS and MALDI-TOF/TOF being widely utilized devices. However, finding biomarkers is still a challenge in proteomics due to their entanglement and dynamic nature. Consequently, using a proteomics technique in conjunction with genomics and bioinformatics will help to interpret the data about biological systems and how illness alters them. However, most studies have only examined a small portion of the blood proteins. This review emphasizes the several types of proteomics, the available approaches, and their applications in numerous research fields.