Electrochemical DNA biosensors developed for the monitoring of biointeractions with drugs: a review

IF 1.3 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Turkish Journal of Chemistry Pub Date : 2023-10-31 DOI:10.55730/1300-0527.3584
KADRİYE ARZUM ERDEM GÜRSAN, MUHAMMED HÜSEYİN ŞENTÜRK, ESMA YILDIZ GÖZ, MELTEM MARAL, AYLA YILDIRIM, AYŞEN BOZOĞLU, BURAK KIVRAK, NESLİHAN CEREN AY
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Abstract

The interaction of drugs with DNA is important for the discovery of novel drug molecules and for understanding the therapeutic effects of drugs as well as the monitoring of side effects. For this reason, many studies have been carried out to investigate the interactions of drugs with nucleic acids. In recent years, a large number of studies have been performed to electrochemically detect drug-DNA interactions. The fast, sensitive, and accurate results of electrochemical techniques have resulted in a leading role for their implementation in this field. By means of electrochemical techniques, it is possible not only to demonstrate drug-DNA interactions but also to quantitatively analyze drugs. In this context, electrochemical biosensors for drug-DNA interactions have been examined under different headings including anticancer, antiviral, antibiotic, and central nervous system drugs as well as DNA-targeted drugs. An overview of the studies related to electrochemical DNA biosensors developed for the detection of drug-DNA interactions that were reported in the last two decades in the literature is presented herein along with their applications and they are discussed together with their future perspectives.
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用于监测生物与药物相互作用的电化学DNA生物传感器的研究进展
药物与DNA的相互作用对于发现新的药物分子、了解药物的治疗效果以及监测副作用非常重要。因此,人们开展了许多研究来研究药物与核酸的相互作用。近年来,人们进行了大量的电化学检测药物- dna相互作用的研究。电化学技术快速、灵敏、准确的结果使其在该领域的应用具有主导作用。通过电化学技术,不仅可以证明药物- dna相互作用,而且可以定量分析药物。在此背景下,用于药物- dna相互作用的电化学生物传感器已经在不同的标题下进行了研究,包括抗癌,抗病毒,抗生素,中枢神经系统药物以及dna靶向药物。本文概述了过去二十年来在文献中报道的用于检测药物-DNA相互作用的电化学DNA生物传感器的相关研究,以及它们的应用,并讨论了它们的未来前景。
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来源期刊
Turkish Journal of Chemistry
Turkish Journal of Chemistry 化学-工程:化工
CiteScore
2.40
自引率
7.10%
发文量
87
审稿时长
3 months
期刊介绍: The Turkish Journal of Chemistry is a bimonthly multidisciplinary journal published by the Scientific and Technological Research Council of Turkey (TÜBİTAK). The journal is dedicated to dissemination of knowledge in all disciplines of chemistry (organic, inorganic, physical, polymeric, technical, theoretical and analytical chemistry) as well as research at the interface with other sciences especially in chemical engineering where molecular aspects are key to the findings. The journal accepts English-language original manuscripts and contribution is open to researchers of all nationalities. The journal publishes refereed original papers, reviews, letters to editor and issues devoted to special fields. All manuscripts are peer-reviewed and electronic processing ensures accurate reproduction of text and data, plus publication times as short as possible.
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