Synthesis and characterization of CuO nanoparticle: Its electrochemical paracetamol sensor activity and substituted-2-aminothiophene synthesis applications

Abstract

In the present work, the synthesized nanoparticle was examined by multiple characterization techniques for physico-chemical, surface-morphological, elemental, and optical properties. These structural parameters of achieved nano-catalyst was studied by using P-XRD, SEM-EDAX, FT-IR and Energy band gap techniques. The electrochemical analysis of synthesized CuO nanoparticle modified with carbon paste was investigated using 0.1 M KCl under different scan rates of 0.01-0.05 V/s. The sensing activity of prepared material was performed for Paracetamol medicine at concentration 1-5 mM in the potential range of – 1.0 V to + 1.0 V using cyclic voltametric analysis. Microwave accelerated synthesis of substituted-2-aminothiophene by a 3-component (acetophenone, malononitrile and elemental sulphur) one pot Gewald reaction using low-cost nano-catalyst (CuO nanoparticle) to perform for chemical reactions. The synthesized compounds were confirmed by FT-IR, 1HNMR, 13C NMR and Mass spectral techniques. The antibacterial activity was examined using Bacillus cereus (gram positive) & Ciprofoxin (gram negative) organism and evaluated antifungal activities using Candida albicans (gram positive) & Itraconazole (gram negative) organism for prepared organic compounds tested under agar diffusion method. Molecular docking studies were discussed for both carboxylate and carbonitrile derivatives at the active site of the bacterial protein GlcN-6-P synthase. Green chemistry encourages the design of synthetic processes that minimize the use and generation of hazardous substances.