Matrix metalloproteinases: the role in evolution of liver diseases

Abstract

Chronic liver diseases are characterized by the activation of stellate cells and increased extracellular matrix (ECM) accumulation, which leads to the evolution and advancement of liver fibrosis. Hepatic fibrogenesis is based on an imbalance be-tween the collection and degradation of ECM, caused, among other things, by impaired matrix metalloproteinases (MMPs) expression. The review presents data on the biological role of various MMPs in normal and liver diseases. Clarifying the place of MMP in noninvasive and early diagnosis of chronic liver diseases will optimize the management of this category of patients.