Green synthesis of silver nanoparticles via Taxus wallichiana Zucc. plant-derived Taxol: Novel utilization as anticancer, antioxidation, anti-inflammation, and antiurolithic potential

IF 3.8 4区工程技术 Q2 CHEMISTRY, MULTIDISCIPLINARY Green Processing and Synthesis Pub Date : 2023-01-01 DOI:10.1515/gps-2023-0051

Sachin Bhusari, Parvindar M. Sah, Jaya Lakkakula, Arpita Roy, Rajesh Raut, Ramesh Chondekar, Saad Alghamdi, Mazen Almehmadi, Mamdouh Allahyani, Ahad Amer Alsaiari, Abdulelah Aljuaid, Nabeela Al-Abdullah

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Abstract

Abstract Throughout history, the utilization of plant products as medicinal remedies has been widespread, with numerous modern drugs finding their origins in the plant kingdom. Taxol, derived from Taxus species, stands out as an exceptional and highly potent anticancer medication. In this study, we present a rapid one-pot synthesis method for silver nanoparticles (AgNPs) using the leaves of Taxus wallichiana Zucca in the presence of sunlight. The synthesized AgNPs were comprehensively characterized using X-ray diffraction, transmission electron microscopy, and HPLC Q-TOF. The AgNPs were further investigated for their antioxidative, anticancer, anti-inflammatory, and antiurolithi properties. The anticancer activity was assessed through a sulforhodamine B assay conducted on the MDA-MB-231 human breast carcinoma cell line and SiHa human cervical cancer cell line. The findings of this study reveal the impressive antioxidative, anticancer, anti-inflammatory, and antiurolithi characteristics exhibited by AgNPs synthesized from leaf extracts. This research highlights an environmentally friendly and cost-effective approach to producing AgNPs by utilizing plant extracts as reducing agents, underscoring the immense potential of natural resources in advancing nanotechnology and its applications.

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利用红豆杉绿色合成纳米银颗粒。植物源性紫杉醇:抗癌、抗氧化、抗炎和抗尿石的新用途

纵观历史，植物产品作为药物的利用一直很普遍，许多现代药物都起源于植物界。紫杉醇是从红豆杉中提取的，是一种特殊而高效的抗癌药物。在这项研究中，我们提出了一种快速的一锅合成银纳米粒子(AgNPs)的方法，该方法使用红豆杉(Taxus wallichiana Zucca)叶片在阳光存在下合成。采用x射线衍射、透射电镜和HPLC Q-TOF对合成的AgNPs进行了全面表征。AgNPs进一步研究了其抗氧化、抗癌、抗炎和抗尿石的特性。对MDA-MB-231人乳腺癌细胞株和SiHa人宫颈癌细胞株进行了磺胺丹B抗肿瘤活性测定。本研究结果揭示了由叶子提取物合成的AgNPs具有令人印象深刻的抗氧化、抗癌、抗炎和抗尿石的特性。这项研究强调了利用植物提取物作为还原剂生产AgNPs的一种环境友好和经济有效的方法，强调了自然资源在推进纳米技术及其应用方面的巨大潜力。

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来源期刊

Green Processing and Synthesis CHEMISTRY, MULTIDISCIPLINARY-ENGINEERING, CHEMICAL

CiteScore

6.70

自引率

9.30%

发文量

审稿时长

7 weeks

期刊介绍： Green Processing and Synthesis is a bimonthly, peer-reviewed journal that provides up-to-date research both on fundamental as well as applied aspects of innovative green process development and chemical synthesis, giving an appropriate share to industrial views. The contributions are cutting edge, high-impact, authoritative, and provide both pros and cons of potential technologies. Green Processing and Synthesis provides a platform for scientists and engineers, especially chemists and chemical engineers, but is also open for interdisciplinary research from other areas such as physics, materials science, or catalysis.