Calcipotriene/Betamethasone Dipropionate Foam as a Potential Safe and Effective Treatment of Nail Psoriasis

IF 1.4 Q3 DERMATOLOGY Skin Appendage Disorders Pub Date : 2023-10-17 DOI:10.1159/000533994
Alia Abbas, Sima Amin, Adaugo Sanyi, Tiffany Mayo, Boni Elewski
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Abstract

Background: Nail psoriasis is a common condition that affects quality of life in individuals with psoriasis and psoriatic arthritis. Topical treatments have been shown to be effective in treating nail bed disease but not as effective in treating nail matrix diseases, which often requires intralesional corticosteroids. Objectives: The objective of this open-label study was to evaluate the efficacy of combination calcipotriol/betamethasone dipropionate foam as a treatment for nail psoriasis including nail matrix disease. Method: We report three patients with moderate to severe nail psoriasis with involvement of all ten fingernails who applied study foam nightly for 6 months. Nails were assessed using the NAPSI score evaluating both nail bed and nail matrix disease. Results: NAPSI score improved including nail matrix disease in the majority of nails. No skin irritation or unexpected adverse events occurred. Conclusions: We conclude this foam combination product could be an effective and safe treatment for fingernail psoriasis and may provide better nail matrix penetration as evidenced by improvement in nail matrix score. Further studies are needed for additional evaluation.
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钙泊三烯/二丙酸倍他米松泡沫作为一种潜在安全有效的治疗指甲银屑病的方法
背景:甲牛皮癣是影响牛皮癣和银屑病关节炎患者生活质量的常见疾病。局部治疗已被证明对治疗甲床疾病有效,但对治疗甲基质疾病不那么有效,这通常需要局部皮质类固醇。目的:这项开放标签研究的目的是评估钙三醇/二丙酸倍他米松泡沫联合治疗甲牛皮癣(包括甲基质病)的疗效。方法:我们报告了3例中度至重度指甲牛皮癣患者,所有十个指甲都受累,每晚应用研究泡沫6个月。采用NAPSI评分评估甲床和甲基质疾病。结果:NAPSI评分改善,包括大多数指甲基质疾病。无皮肤刺激或意外不良事件发生。结论:该泡沫组合产品可以有效、安全地治疗指甲型银屑病,并且可以提供更好的甲基质穿透,甲基质评分的提高证明了这一点。需要进一步的研究来进一步评价。
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来源期刊
CiteScore
2.00
自引率
10.00%
发文量
69
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