Ec Peptide of the IGF-1Ec Isoform in Relation to Prostate Cancer: Brief Review and Latest Data

Abstract

Abstract Prostate cancer is a complex disease that affects millions of men worldwide, mainly in areas with high human growth rates; is a major cause of disease and mortality among men. The most common treatment is surgical or medical castration. The last few years, the role of IGF-1 is well established in cancer biology. In many studies Ec peptide is associated with prostate cancer and metastasis and it seems that it is an important progression factor for human prostate cancer cells. It is defined the potential role in tumor growth, progression and metastasis. This scientific article is about the Ec peptide of the IGF1Ec isoform and its association with prostate cancer, the proliferation of PC-3 by PEc through an autocrine/paracrine mode of action, the association of the Ec peptide with epithelial mesenchymal transition and finally the Ec peptide with prostate cancer metastasis.