Paclitaxel-Induced Periarticular Thenar Erythema with Onycholysis Syndrome

IF 1.4 Q3 DERMATOLOGY Skin Appendage Disorders Pub Date : 2023-10-11 DOI:10.1159/000534118
Japnoor Kaur, Vishal Gaurav, Mehul Tyagi
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Abstract

Introduction: Periarticular thenar erythema with onycholysis (PATEO) syndrome is a rare subtype of hand-foot syndrome seen in patients undergoing taxane-based chemotherapy. It presents as erythematous to violaceous plaques on the dorsum of hands, feet, and around the Achilles tendon along with nail changes, particularly onycholysis. Case Presentation: A 39-year-old female on paclitaxel chemotherapy for stage IIIA (T3N2aM0) invasive ductal breast carcinoma, presented with mildly tender erythematous to violaceous plaques involving the dorsa of bilateral hands and feet, in the periarticular areas of the Achilles tendon, with facial involvement. All fingernails showed shortening, orange-red chromonychia, Beau’s lines, onychoschizia, and subungual debris. The toenail involvement was relatively less severe, with distal onycholysis being the predominant finding. The patient showed significant improvement in cutaneous lesions with topical steroid therapy and was advised cold water immersion during subsequent chemotherapy infusions. Discussion: A shorter interval between cycles and a higher cumulative number of cycles correlate with severity of dermatitis and nail involvement. Rarely, periocular and facial involvement can occur concurrently with PATEO syndrome. This case is being reported to increase awareness about this entity facilitating early diagnosis and treatment.
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紫杉醇诱导的关节周围鱼际红斑伴溶甲综合征
& lt; b> & lt; i>简介:& lt; / i> & lt; / b>关节周围鱼际红斑伴软骨溶解(PATEO)综合征是一种罕见的手足综合征亚型,见于接受紫杉烷类化疗的患者。它表现为手背、脚背和跟腱周围的红斑到紫色斑块,并伴有指甲变化,尤其是骨关节溶解。& lt; b> & lt; i>案例表示:& lt; / i> & lt; / b>39岁女性,因IIIA期(T3N2aM0)浸润性导管性乳腺癌接受紫杉醇化疗,表现为双侧手、足背、跟腱关节周围区域出现轻度嫩痛性红斑至紫色斑块,累及面部。所有指甲均呈缩短、橙红色色痕、博氏纹、甲裂和趾下碎片。趾甲受累相对较轻,主要表现为远端骨关节溶解。在局部类固醇治疗下,患者的皮肤病变得到了显著改善,在随后的化疗输注中建议冷水浸泡。& lt; b> & lt; i>讨论:& lt; / i> & lt; / b>较短的周期间隔和较高的周期累积次数与皮炎和指甲受累的严重程度相关。极少情况下,眼周和面部受累可同时发生博泰综合征。报告这一病例是为了提高对这一实体的认识,促进早期诊断和治疗。
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CiteScore
2.00
自引率
10.00%
发文量
69
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