Paclitaxel-Induced Periarticular Thenar Erythema with Onycholysis Syndrome

IF 1.4 Q3 DERMATOLOGY Skin Appendage Disorders Pub Date : 2023-10-11 DOI:10.1159/000534118
Japnoor Kaur, Vishal Gaurav, Mehul Tyagi
{"title":"Paclitaxel-Induced Periarticular Thenar Erythema with Onycholysis Syndrome","authors":"Japnoor Kaur, Vishal Gaurav, Mehul Tyagi","doi":"10.1159/000534118","DOIUrl":null,"url":null,"abstract":"<b><i>Introduction:</i></b> Periarticular thenar erythema with onycholysis (PATEO) syndrome is a rare subtype of hand-foot syndrome seen in patients undergoing taxane-based chemotherapy. It presents as erythematous to violaceous plaques on the dorsum of hands, feet, and around the Achilles tendon along with nail changes, particularly onycholysis. <b><i>Case Presentation:</i></b> A 39-year-old female on paclitaxel chemotherapy for stage IIIA (T3N2aM0) invasive ductal breast carcinoma, presented with mildly tender erythematous to violaceous plaques involving the dorsa of bilateral hands and feet, in the periarticular areas of the Achilles tendon, with facial involvement. All fingernails showed shortening, orange-red chromonychia, Beau’s lines, onychoschizia, and subungual debris. The toenail involvement was relatively less severe, with distal onycholysis being the predominant finding. The patient showed significant improvement in cutaneous lesions with topical steroid therapy and was advised cold water immersion during subsequent chemotherapy infusions. <b><i>Discussion:</i></b> A shorter interval between cycles and a higher cumulative number of cycles correlate with severity of dermatitis and nail involvement. Rarely, periocular and facial involvement can occur concurrently with PATEO syndrome. This case is being reported to increase awareness about this entity facilitating early diagnosis and treatment.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":null,"pages":null},"PeriodicalIF":1.4000,"publicationDate":"2023-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Skin Appendage Disorders","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1159/000534118","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"DERMATOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Introduction: Periarticular thenar erythema with onycholysis (PATEO) syndrome is a rare subtype of hand-foot syndrome seen in patients undergoing taxane-based chemotherapy. It presents as erythematous to violaceous plaques on the dorsum of hands, feet, and around the Achilles tendon along with nail changes, particularly onycholysis. Case Presentation: A 39-year-old female on paclitaxel chemotherapy for stage IIIA (T3N2aM0) invasive ductal breast carcinoma, presented with mildly tender erythematous to violaceous plaques involving the dorsa of bilateral hands and feet, in the periarticular areas of the Achilles tendon, with facial involvement. All fingernails showed shortening, orange-red chromonychia, Beau’s lines, onychoschizia, and subungual debris. The toenail involvement was relatively less severe, with distal onycholysis being the predominant finding. The patient showed significant improvement in cutaneous lesions with topical steroid therapy and was advised cold water immersion during subsequent chemotherapy infusions. Discussion: A shorter interval between cycles and a higher cumulative number of cycles correlate with severity of dermatitis and nail involvement. Rarely, periocular and facial involvement can occur concurrently with PATEO syndrome. This case is being reported to increase awareness about this entity facilitating early diagnosis and treatment.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
紫杉醇诱导的关节周围鱼际红斑伴溶甲综合征
& lt; b> & lt; i>简介:& lt; / i> & lt; / b>关节周围鱼际红斑伴软骨溶解(PATEO)综合征是一种罕见的手足综合征亚型,见于接受紫杉烷类化疗的患者。它表现为手背、脚背和跟腱周围的红斑到紫色斑块,并伴有指甲变化,尤其是骨关节溶解。& lt; b> & lt; i>案例表示:& lt; / i> & lt; / b>39岁女性,因IIIA期(T3N2aM0)浸润性导管性乳腺癌接受紫杉醇化疗,表现为双侧手、足背、跟腱关节周围区域出现轻度嫩痛性红斑至紫色斑块,累及面部。所有指甲均呈缩短、橙红色色痕、博氏纹、甲裂和趾下碎片。趾甲受累相对较轻,主要表现为远端骨关节溶解。在局部类固醇治疗下,患者的皮肤病变得到了显著改善,在随后的化疗输注中建议冷水浸泡。& lt; b> & lt; i>讨论:& lt; / i> & lt; / b>较短的周期间隔和较高的周期累积次数与皮炎和指甲受累的严重程度相关。极少情况下,眼周和面部受累可同时发生博泰综合征。报告这一病例是为了提高对这一实体的认识,促进早期诊断和治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
CiteScore
2.00
自引率
10.00%
发文量
69
期刊最新文献
Trichoscopy of Discoid Lupus Erythematosus in Caucasian Scalp: A Review. We Need to Nail It: Dermatology Resident Survey Highlighting Lack of Education for Nail Matrix Biopsies The Comparative Effects of Monotherapy with Topical Minoxidil, Oral Finasteride, and Topical Finasteride in Postmenopausal Women with Pattern Hair Loss: A Retrospective Cohort Study. Erratum. Erratum.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1