{"title":"Evaluation of the Detoxifying Ability of Humic Acids in Relation to Antibiotics","authors":"N.Yu. Grechishcheva, E.D. Dmitrieva, E.V. Akatova, V.I. Balaba, V.L. Zavorotny","doi":"10.18412/1816-0395-2023-10-30-35","DOIUrl":null,"url":null,"abstract":"The detoxifying ability of lowland peat humic acids at 10 to 110 mg/l concentration with respect to tetracycline, doxycycline, and cefotaxime was studied by bioanalysis on Escherichia coli K-802 strain. It was confirmed that, according to sensitivity to the presence of humic substances, the studied antibiotics were ranked as follows: cefotaxime > doxycycline > tetracycline. Humic acids were found to exhibit maximum detoxifying effect against cefotaxime in the entire concentration range. It was found that detoxification with respect to cefotaxime occurs mainly due to the binding of the antibiotic into non-toxic complexes, and for doxycycline and tetracycline – due to the inherent action of humic acids on the test object with a minimal contribution to binding. Enhancement of antimicrobial effect in the presence of humic acids above 60 mg/litre for tetracycline was recorded.","PeriodicalId":11462,"journal":{"name":"Ecology and Industry of Russia","volume":"45 Suppl 3 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ecology and Industry of Russia","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.18412/1816-0395-2023-10-30-35","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Environmental Science","Score":null,"Total":0}
引用次数: 0
Abstract
The detoxifying ability of lowland peat humic acids at 10 to 110 mg/l concentration with respect to tetracycline, doxycycline, and cefotaxime was studied by bioanalysis on Escherichia coli K-802 strain. It was confirmed that, according to sensitivity to the presence of humic substances, the studied antibiotics were ranked as follows: cefotaxime > doxycycline > tetracycline. Humic acids were found to exhibit maximum detoxifying effect against cefotaxime in the entire concentration range. It was found that detoxification with respect to cefotaxime occurs mainly due to the binding of the antibiotic into non-toxic complexes, and for doxycycline and tetracycline – due to the inherent action of humic acids on the test object with a minimal contribution to binding. Enhancement of antimicrobial effect in the presence of humic acids above 60 mg/litre for tetracycline was recorded.
期刊介绍：
The Journal "Ekologia i promyshlennost Rossii" («Ecology and Industry of Russia») is aimed to promote acquaintance of the world scientific and technical public and specialists, interested in the problems of the environment protection, with advanced achievements of the science and engineering practice on securing of stable (self-supporting) evolution within the limits of the United Nations accepted recommendations (RIO 92 and RIO+20). A circle of papers includes basic researches and engineering decisions, analytical and methodical operations, reviews on journal subjects. The journal lays special emphasis on methodical elaborations, analytical investigations in the sphere of creating the ecological culture of the population, to the features of ecological education in higher schools of the country for the sake of actualization in specialists'' consciousness of the scientific necessity to know environmental problems of the modern civilization and paths of their settlement. Original papers and investigations of scientists and specialists on separate themes occupy an independent niche of issues under the «Cover story» heading. The journal task is to promote practical implementation of scientific and engineering decisions in the field of decrease of anthropogenic load on the biosphere and environment protection (open lectures, round tables, discussions and so forth). Ecology and Industry of Russia is an informational reference book about the newest developments of the Russian and foreign scientists and the companies realized in Russia, the CIS and Baltic countries, and far-abroad countries. The journal publishes information reports about holding in Russia and abroad the international, all-Russian and regional congresses, conferences, and symposiums related to the journal subjects.
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