A Cutting-Edge Method for Regulated Drug Delivery - Microencapsulation

Harshitha V., Vivek D., Jaipal S.
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Abstract

Microencapsulation is the process of encasing, coating, or surrounding a very small droplet of particle, such as a solid, liquid, or even a gas, with a polymeric particle. In comparison to other parenteral controlled release dosage forms, such as macro-sized implants, microparticles offer a number of important benefits as drug delivery systems, including I an efficient protection of the encapsulated active agent against (e.g. enzymatic) degradation, (ii) the ability to precisely control the release rate of the incorporated drug over periods of hours to months, (iii) an easy administration, and (iv) desired, pre-programmed drug release. There are various methods to chemically encapsulate the substance, including the coacervation approach, the polymeric-polymeric incompatibility method, and the physical method, which include the centrifugal extrusion process, pan coating, spray drying, and the air suspension method. Core material, which is the required substance to be coated, and coating material are the most crucial materials utilised in microencapsulation (which is capable of forming film). Because it applies to the pharmaceutical, agricultural, food, and construction industries. Due to its precise action and minimal adverse effects, it is a better drug delivery technique than conventional drug delivery systems.
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调控药物递送的前沿方法——微胶囊化
微胶囊化是用聚合物颗粒包裹、包裹或包裹非常小的颗粒液滴(如固体、液体甚至气体)的过程。与其他肠外控释剂型(如大尺寸植入物)相比,微颗粒作为药物递送系统提供了许多重要的好处,包括1有效保护被封装的活性剂免受(例如酶)降解,(ii)能够在数小时至数月的时间内精确控制合并药物的释放速度,(iii)易于给药,以及(iv)期望的预编程药物释放。化学包封物质的方法有多种,包括凝聚法、聚合物-聚合物不相容法和物理法,包括离心挤压法、锅包覆法、喷雾干燥法和空气悬浮法。核心材料是需要被涂覆的物质,涂层材料是微胶囊化(能够形成薄膜)中最关键的材料。因为它适用于制药、农业、食品和建筑行业。由于其作用精确,副作用小,是一种比传统给药系统更好的给药技术。
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