Nanorobotics, a rapidly evolving field at the intersection of nanotechnology and robotics, holds immense promise in revolutionizing pharmaceutical drug delivery and development. This comprehensive review article explores the various facets of nanorobotics and its pivotal role in the advancement of medicine. The article begins with an introduction to nanorobotics, providing a definition and historical background to contextualize its significance. Subsequently, it delves into nanorobotics' role in drug delivery, highlighting the challenges faced in conventional methods and the advantages of employing nanorobot-based systems. The review further explores nanorobotics in drug development, emphasizing its contribution to accelerating drug discovery and enabling personalized medicine. It discusses the different types of nanorobots utilized in pharmaceutical applications, including molecular, cellular, and hybrid systems. Additionally, the article covers the fabrication and propulsion techniques of nanorobots, along with navigation and control strategies. Furthermore, it delves into the interaction of nanorobots with biological systems and their potential applications in site-specific drug delivery and disease treatment. Ethical and regulatory considerations pertinent to nanorobotics in pharmaceuticals are also addressed. Finally, the review offers insights into future perspectives and challenges in the field, envisioning advanced drug delivery systems, targeted therapies, nanorobot swarms, and biohybrids. By comprehensively examining the subject, this review article presents a holistic understanding of nanorobotics potential in reshaping pharmaceutical practices for precision medicine and improved patient outcomes.
{"title":"Nanorobotics: Pioneering Drug Delivery and Development in Pharmaceuticals","authors":"Prakash Nathaniel Kumar Sarella, Anil Kumar Vipparthi, Surekha Valluri, Srujala Vegi, Veera Kumari Vendi","doi":"10.52711/0975-4377.2024.00014","DOIUrl":"https://doi.org/10.52711/0975-4377.2024.00014","url":null,"abstract":"Nanorobotics, a rapidly evolving field at the intersection of nanotechnology and robotics, holds immense promise in revolutionizing pharmaceutical drug delivery and development. This comprehensive review article explores the various facets of nanorobotics and its pivotal role in the advancement of medicine. The article begins with an introduction to nanorobotics, providing a definition and historical background to contextualize its significance. Subsequently, it delves into nanorobotics' role in drug delivery, highlighting the challenges faced in conventional methods and the advantages of employing nanorobot-based systems. The review further explores nanorobotics in drug development, emphasizing its contribution to accelerating drug discovery and enabling personalized medicine. It discusses the different types of nanorobots utilized in pharmaceutical applications, including molecular, cellular, and hybrid systems. Additionally, the article covers the fabrication and propulsion techniques of nanorobots, along with navigation and control strategies. Furthermore, it delves into the interaction of nanorobots with biological systems and their potential applications in site-specific drug delivery and disease treatment. Ethical and regulatory considerations pertinent to nanorobotics in pharmaceuticals are also addressed. Finally, the review offers insights into future perspectives and challenges in the field, envisioning advanced drug delivery systems, targeted therapies, nanorobot swarms, and biohybrids. By comprehensively examining the subject, this review article presents a holistic understanding of nanorobotics potential in reshaping pharmaceutical practices for precision medicine and improved patient outcomes.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140439306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-22DOI: 10.52711/0975-4377.2024.00001
Riyaz Ahmad, Jaza Quazi, Wajid Ahmad, Vishal Thakre, Vicky Rai
Acne is a type of skin infection. It usually happens during puberty, when the sebaceous (oil) glands begin to function. Androgens are produced by the male and female adrenal glands and stimulate the glands. Acne vulgaris is a type of acne that means "common acne." It is a skin infection caused by sebaceous gland changes. The red colour is caused by skin inflammation caused by infection in the skin. Acne is a general skin condition that is associated with pimples and is common among teenagers. An anti-acne gel of Benzoyl peroxide containing silver nanoparticle was prepared using carbopol as a polymer and water as a solvent, and then incorporated into a topical gel using a magnetic stirrer. The product was checked for its physicochemical properties. The prepared gel’s pH, spread ability, drug content, viscosity, drug release, and antibacterial activity were statistically optimized and evaluated. The antibacterial and anti-acne activities of the various formulations were checked and compared with commercially available formulations using a modified agar well diffusion method for Staphylococcus aureus cultures. Prepared topical gel of Benzoyl peroxide was shown the pH range 5 to 6, viscosity 434±36.56 to 651±41.43 cp, spread ability range 15.29 to 24. 51g.cm/sec, zone of inhibition ranges 12.23 to 21.65mm, drug content ranges 91.26±0.74 to 98.74±0.63%, the drug release of gel formulation was after 12 hour was 80.74 to 71.52. The preparation of silver nanoparticles and incorporation into the Benzoyl peroxide-containing gel were done successfully. Various evaluations, i.e., the physiochemical analysis, spread ability, viscosity, drug content, drug release, and antibacterial study were done. This study demonstrates that the gel has a good texture, is easily spreadable, has high bioavailability, and is effective in treating acne.
{"title":"Development and Characterization Silver Nitrate Nanoparticles Gel containing Benzoyl peroxide for the Treatment of Acne","authors":"Riyaz Ahmad, Jaza Quazi, Wajid Ahmad, Vishal Thakre, Vicky Rai","doi":"10.52711/0975-4377.2024.00001","DOIUrl":"https://doi.org/10.52711/0975-4377.2024.00001","url":null,"abstract":"Acne is a type of skin infection. It usually happens during puberty, when the sebaceous (oil) glands begin to function. Androgens are produced by the male and female adrenal glands and stimulate the glands. Acne vulgaris is a type of acne that means \"common acne.\" It is a skin infection caused by sebaceous gland changes. The red colour is caused by skin inflammation caused by infection in the skin. Acne is a general skin condition that is associated with pimples and is common among teenagers. An anti-acne gel of Benzoyl peroxide containing silver nanoparticle was prepared using carbopol as a polymer and water as a solvent, and then incorporated into a topical gel using a magnetic stirrer. The product was checked for its physicochemical properties. The prepared gel’s pH, spread ability, drug content, viscosity, drug release, and antibacterial activity were statistically optimized and evaluated. The antibacterial and anti-acne activities of the various formulations were checked and compared with commercially available formulations using a modified agar well diffusion method for Staphylococcus aureus cultures. Prepared topical gel of Benzoyl peroxide was shown the pH range 5 to 6, viscosity 434±36.56 to 651±41.43 cp, spread ability range 15.29 to 24. 51g.cm/sec, zone of inhibition ranges 12.23 to 21.65mm, drug content ranges 91.26±0.74 to 98.74±0.63%, the drug release of gel formulation was after 12 hour was 80.74 to 71.52. The preparation of silver nanoparticles and incorporation into the Benzoyl peroxide-containing gel were done successfully. Various evaluations, i.e., the physiochemical analysis, spread ability, viscosity, drug content, drug release, and antibacterial study were done. This study demonstrates that the gel has a good texture, is easily spreadable, has high bioavailability, and is effective in treating acne.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140440360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The research scheme of formulation and evaluation of extended-release oral suspension of metformin hydrochloride with the objective to develop a stable, redispersible oral liquid suspension based on extended-release pellets to facilitate swallowing in patients with diabetes. Pellets were prepared by using Bed Coating During Sliding method with the Metformin hydrochloride used as antidiabetic drug and various polymers. Extended release was affected by the ethylcellulose coating of drug formulation used as coating agent, MCC, Lactose, PVP K-30 Prepared metformin hydrochloride pellets putted in to prepared sugar free syrup vehicle using polymers like Xanthan Gum as a suspending agent for uniform drug distribution, Sorbitol solution, Aspartame are artificial sweeteners, Sodium Citrate, Potassium sorbate, Methyl paraben. The formulation was optimized based on Design expert software and Central Composite Design was used for study. Drug and polymers were studied for compatibility and interaction study, carried out by FTIR and DSC and found to be compatible to each other. The Redispersibility, Sedimentation volume, Sedimentation rate, Rheological Study, Viscosity, Specific gravity, Particle Size, dissolution study and %Drug content of formulated batches was evaluated. All the results were within the acceptable pharmacopeial limits and were evaluated statistically by using one way ANOVA test for quadratic model. From the result, MET6 batch was observed optimized formulation because up to 8 hrs 85.25% drug was released. kinetic studies of the drug release for optimized formulation follows zero order kinetics.
{"title":"Formulation and Evaluation of Extended Release Oral Suspension of Metformin Hydrochloride","authors":"Dipali Patil, Shashikant Barhate, Manoj Bari, Shaikh Samir","doi":"10.52711/0975-4377.2024.00002","DOIUrl":"https://doi.org/10.52711/0975-4377.2024.00002","url":null,"abstract":"The research scheme of formulation and evaluation of extended-release oral suspension of metformin hydrochloride with the objective to develop a stable, redispersible oral liquid suspension based on extended-release pellets to facilitate swallowing in patients with diabetes. Pellets were prepared by using Bed Coating During Sliding method with the Metformin hydrochloride used as antidiabetic drug and various polymers. Extended release was affected by the ethylcellulose coating of drug formulation used as coating agent, MCC, Lactose, PVP K-30 Prepared metformin hydrochloride pellets putted in to prepared sugar free syrup vehicle using polymers like Xanthan Gum as a suspending agent for uniform drug distribution, Sorbitol solution, Aspartame are artificial sweeteners, Sodium Citrate, Potassium sorbate, Methyl paraben. The formulation was optimized based on Design expert software and Central Composite Design was used for study. Drug and polymers were studied for compatibility and interaction study, carried out by FTIR and DSC and found to be compatible to each other. The Redispersibility, Sedimentation volume, Sedimentation rate, Rheological Study, Viscosity, Specific gravity, Particle Size, dissolution study and %Drug content of formulated batches was evaluated. All the results were within the acceptable pharmacopeial limits and were evaluated statistically by using one way ANOVA test for quadratic model. From the result, MET6 batch was observed optimized formulation because up to 8 hrs 85.25% drug was released. kinetic studies of the drug release for optimized formulation follows zero order kinetics.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140438236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Liposomal drug design has emerged as a promising approach for targeted drug delivery. This article provides an overview of the principles and strategies involved in liposomal drug design, focusing on optimizing drug stability, controlled release, and enhanced therapeutic outcomes. The composition of liposomes, including the selection of lipids, plays a crucial role in determining their properties. Size and surface modifications of liposomes enable targeted drug delivery to specific tissues or cells. Liposomes offer versatility in drug encapsulation and controlled release kinetics, improving therapeutic efficacy while minimizing side effects. Incorporating targeting ligands onto liposome surfaces enhances their affinity for diseased sites, allowing for selective drug accumulation. Stability and manufacturing considerations are vital for the successful translation of liposomal drug delivery systems. Overall, liposomal drug design holds significant potential in revolutionizing drug delivery for improved treatment outcomes.
{"title":"Advancing Therapeutics with Liposomal Drug Design: Harnessing the Potential of Liposomes for Targeted Drug Delivery","authors":"Rupali Singh, Sachi Sharma, Sonia Awatar, Dashain Purva, Arjun Singh","doi":"10.52711/0975-4377.2024.00019","DOIUrl":"https://doi.org/10.52711/0975-4377.2024.00019","url":null,"abstract":"Liposomal drug design has emerged as a promising approach for targeted drug delivery. This article provides an overview of the principles and strategies involved in liposomal drug design, focusing on optimizing drug stability, controlled release, and enhanced therapeutic outcomes. The composition of liposomes, including the selection of lipids, plays a crucial role in determining their properties. Size and surface modifications of liposomes enable targeted drug delivery to specific tissues or cells. Liposomes offer versatility in drug encapsulation and controlled release kinetics, improving therapeutic efficacy while minimizing side effects. Incorporating targeting ligands onto liposome surfaces enhances their affinity for diseased sites, allowing for selective drug accumulation. Stability and manufacturing considerations are vital for the successful translation of liposomal drug delivery systems. Overall, liposomal drug design holds significant potential in revolutionizing drug delivery for improved treatment outcomes.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140438652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-22DOI: 10.52711/0975-4377.2024.00009
Aishwarya R, Hindustan Abdul Ahad, Varsha S, Ranjitha V
Bower and Sulez's work on global pharmaceutical strategy stands as a comprehensive analysis of the intricate landscape within this highly regulated and fiercely competitive industry. This article delve into critical themes, including regulatory compliance, market access strategies, and the role of innovation, acknowledging the industry's complexity marked by stringent regulations and intense competition. Emphasizing a holistic approach, the study explores nuanced strategies for navigating diverse regulatory frameworks globally, effective market entry, pricing considerations, and adapting to regional healthcare needs. Furthermore, the article highlight the significance of research and development, providing insights into fostering innovation, safeguarding intellectual property, and strategic collaborations. The work offers a balanced framework, addressing challenges and opportunities, making it a valuable resource for industry practitioners and future research in the dynamic global pharmaceutical sector.
{"title":"Navigating the Global Landscape: A Comprehensive Review of Bower and Sulez's Strategic Insights in the Pharmaceutical Industry","authors":"Aishwarya R, Hindustan Abdul Ahad, Varsha S, Ranjitha V","doi":"10.52711/0975-4377.2024.00009","DOIUrl":"https://doi.org/10.52711/0975-4377.2024.00009","url":null,"abstract":"Bower and Sulez's work on global pharmaceutical strategy stands as a comprehensive analysis of the intricate landscape within this highly regulated and fiercely competitive industry. This article delve into critical themes, including regulatory compliance, market access strategies, and the role of innovation, acknowledging the industry's complexity marked by stringent regulations and intense competition. Emphasizing a holistic approach, the study explores nuanced strategies for navigating diverse regulatory frameworks globally, effective market entry, pricing considerations, and adapting to regional healthcare needs. Furthermore, the article highlight the significance of research and development, providing insights into fostering innovation, safeguarding intellectual property, and strategic collaborations. The work offers a balanced framework, addressing challenges and opportunities, making it a valuable resource for industry practitioners and future research in the dynamic global pharmaceutical sector.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140442010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Arthritis is most prevalent disorder and Indomethacin is choice of drug for arthritis. Oral route is most preferred route of drug administration and tablets are the more convenient dosage form. In present research natural polymers guar gum and xanthan gum were used to make sustained release tablet of Indomethacin. Indomethacin release from the tablets was studied in phosphate buffer pH 7.2. The drug release pattern of six different formulations in which xanthan gum and guar gum were used as a retarding material in different proportions was shown in table no. 6. The formulation F1 releases (75.20%) upto 12 hrs whereas the formulation F2 releases the drug (98.81%) in same time. The formulations F3, F4, F5 and F6 release 98.32%, 99.29%, 98.79% and 82.40% respectively. The dissolution pattern of both gums was similar i.e. with drug to polymer ratio (1:1). In present work F1 shows best sustained release upto 12 hrs in which Drug to Polymer ratio was 1:1:0 (Drug : Xanthan gum : Guar gum). In formulation F2 drug release was not sustained and complete release occurs in 12 hrs where the Drug to Polymer ratio was 1:1.67:0 (Drug: Xanthan gum : Guar gum). It was found that on the concentration of xanthan gum decreases the release rate of the drug also decreases. For sustain release there is not much role of Guar Gum reported. Indomethacin drug has been selected which has half-life 4.5 hrs. Hence the present work, an attempt has been made to provide sustained release drug delivery using polymers with Indomethacin as the model drug. Xanthan gum was best able to retard Indomethacin release mechanism even in the presence of a polymer. Polymer can be used to formulate successful sustained release Indomethacin matrix tablets that have desirable characteristics.
{"title":"Formulation and Evaluation of Indomethacin Sustained Release Tablet by using Natural Polymers","authors":"Sudhir Kathane, Shruti Rathore, Shashikant Chandrakar","doi":"10.52711/0975-4377.2024.00006","DOIUrl":"https://doi.org/10.52711/0975-4377.2024.00006","url":null,"abstract":"Arthritis is most prevalent disorder and Indomethacin is choice of drug for arthritis. Oral route is most preferred route of drug administration and tablets are the more convenient dosage form. In present research natural polymers guar gum and xanthan gum were used to make sustained release tablet of Indomethacin. Indomethacin release from the tablets was studied in phosphate buffer pH 7.2. The drug release pattern of six different formulations in which xanthan gum and guar gum were used as a retarding material in different proportions was shown in table no. 6. The formulation F1 releases (75.20%) upto 12 hrs whereas the formulation F2 releases the drug (98.81%) in same time. The formulations F3, F4, F5 and F6 release 98.32%, 99.29%, 98.79% and 82.40% respectively. The dissolution pattern of both gums was similar i.e. with drug to polymer ratio (1:1). In present work F1 shows best sustained release upto 12 hrs in which Drug to Polymer ratio was 1:1:0 (Drug : Xanthan gum : Guar gum). In formulation F2 drug release was not sustained and complete release occurs in 12 hrs where the Drug to Polymer ratio was 1:1.67:0 (Drug: Xanthan gum : Guar gum). It was found that on the concentration of xanthan gum decreases the release rate of the drug also decreases. For sustain release there is not much role of Guar Gum reported. Indomethacin drug has been selected which has half-life 4.5 hrs. Hence the present work, an attempt has been made to provide sustained release drug delivery using polymers with Indomethacin as the model drug. Xanthan gum was best able to retard Indomethacin release mechanism even in the presence of a polymer. Polymer can be used to formulate successful sustained release Indomethacin matrix tablets that have desirable characteristics.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140442096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-22DOI: 10.52711/0975-4377.2024.00012
Rikhav Shah, Dipika Chavda
In current scenario medical experts have long struggled with how to deliver medication to targeted location into the body while also controlling the drug release rate to avoid overdosing. This issue may be resolve through the creation of novel, intricate formulation known as nano sponges. Nano sponges are small sponge, all around size virus, that may hold a range of medication. These microscopic sponges can move through the system until they reach the intended target region, where they adhere to surface and start to release the drug in steady and controlled manner. Nano sponges are a network or 3D polyester scaffold that are spontaneously decompose. These polyesters are combined with cross-linkers agent in a solution to create a nano sponge. When loaded nano sponge’s framework breakdown the drug particle is released. They are mostly in solid form and it can be formulated as oral, parenteral, topical, or inhalation dosage form, several studies havebeen conducted on protein, peptide, genes, anti-cancer biomolecules via nano-particle technology which hep to reduce undesirable effect and enhance efficacy.
{"title":"Nano Sponge: An Emerging Nano-Technology Based Drug Delivery System","authors":"Rikhav Shah, Dipika Chavda","doi":"10.52711/0975-4377.2024.00012","DOIUrl":"https://doi.org/10.52711/0975-4377.2024.00012","url":null,"abstract":"In current scenario medical experts have long struggled with how to deliver medication to targeted location into the body while also controlling the drug release rate to avoid overdosing. This issue may be resolve through the creation of novel, intricate formulation known as nano sponges. Nano sponges are small sponge, all around size virus, that may hold a range of medication. These microscopic sponges can move through the system until they reach the intended target region, where they adhere to surface and start to release the drug in steady and controlled manner. Nano sponges are a network or 3D polyester scaffold that are spontaneously decompose. These polyesters are combined with cross-linkers agent in a solution to create a nano sponge. When loaded nano sponge’s framework breakdown the drug particle is released. They are mostly in solid form and it can be formulated as oral, parenteral, topical, or inhalation dosage form, several studies havebeen conducted on protein, peptide, genes, anti-cancer biomolecules via nano-particle technology which hep to reduce undesirable effect and enhance efficacy.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140438339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-22DOI: 10.52711/0975-4377.2024.00010
Pallavi P. Ahire, Yashpal M. More, Vinay R. Kothawade, Pradnya D. Lahamge
Systems for orodispersible drug delivery are widely used to increase patient compliance and bioavailability. Because of their enhanced solubility, stability profiles, and higher patient compliance compared to traditional tablets and capsules, orodispersible tablets (ODTs) have drawn a lot of attention in the last thirty years. The review of possible developments in ODT technology for drug delivery applications is the article's main goal. ODTs are prepared using a variety of methods, such as mass extrusion, tablet moulding, sublimation, freeze drying, and direct compression. ODTs may be the better option, particularly for GI-sensitive medications and for patients who fall into the paediatric, geriatric, bedridden, postoperative, or other categories and may have trouble swallowing traditional tablets and capsules. When placed on the tongue, ODTs-solid dosage forms containing medication-disintegrate quickly, often within a few seconds. ODTs have higher acceptability because of their increased bioavailability and stability, as well as patient compliance. This article examines current developments in ODT development, including new technologies, drug candidate suitability, and ODT characterization.
{"title":"Review on Orodispersible Tablet","authors":"Pallavi P. Ahire, Yashpal M. More, Vinay R. Kothawade, Pradnya D. Lahamge","doi":"10.52711/0975-4377.2024.00010","DOIUrl":"https://doi.org/10.52711/0975-4377.2024.00010","url":null,"abstract":"Systems for orodispersible drug delivery are widely used to increase patient compliance and bioavailability. Because of their enhanced solubility, stability profiles, and higher patient compliance compared to traditional tablets and capsules, orodispersible tablets (ODTs) have drawn a lot of attention in the last thirty years. The review of possible developments in ODT technology for drug delivery applications is the article's main goal. ODTs are prepared using a variety of methods, such as mass extrusion, tablet moulding, sublimation, freeze drying, and direct compression. ODTs may be the better option, particularly for GI-sensitive medications and for patients who fall into the paediatric, geriatric, bedridden, postoperative, or other categories and may have trouble swallowing traditional tablets and capsules. When placed on the tongue, ODTs-solid dosage forms containing medication-disintegrate quickly, often within a few seconds. ODTs have higher acceptability because of their increased bioavailability and stability, as well as patient compliance. This article examines current developments in ODT development, including new technologies, drug candidate suitability, and ODT characterization.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140438758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-22DOI: 10.52711/0975-4377.2024.00011
Vaibhav V. Kakade, Ravindra B. Laware
Ellagic acid, a polyphenolic compound present in fruits and berries, with wide spectrum of therapeutic and prophylactic activities. It has wide spectrum of therapeutic, prophylactic and nutritional activities. It is traditionally being used for cosmetic and therapeutic purposes for treating hyperpigmentation, skin cancer and many other skin ailments. Unfortunately Ellagic acid suffers from disadvantages of poor solubility, stability, bioavailability, first pass effect and inter subject variability in gut metabolism. This put serious limit over its use as a therapeutic agent. Recently a focus is being made on improving EA delivery to the site of action using various novel drug delivery systems. Presenting EA topically in vesicular drug delivery as niosomes using natural penetration enhancer as almond oil or olive oil can improve its water solubility and transdermal penetration. It was also learned during literature survey that niosomes act as a good delivery system for hydrophobic drug and serve to increase their dermal penetration. Niosomal gel increases formulation stability and offer to increase drug penetration further and achieve controlled release drug delivery. Literature survey revealed that essential oils as olive, almond or mustard oil act as good natural penetration enhancer for drug in trasndermal gel formulation.
鞣花酸是一种存在于水果和浆果中的多酚化合物，具有广泛的治疗和预防作用。它具有广泛的治疗、预防和营养活性。传统上，它被用于美容和治疗色素沉着、皮肤癌和许多其他皮肤疾病。遗憾的是，鞣花酸存在溶解性差、稳定性差、生物利用率低、首过效应和肠道代谢中受试者间差异性大等缺点。这严重限制了它作为治疗剂的使用。最近，人们开始关注利用各种新型给药系统改善 EA 在作用部位的给药效果。使用天然渗透促进剂（如杏仁油或橄榄油）将 EA 局部呈现为泡囊给药，可以提高其水溶性和透皮渗透性。在文献调查中还了解到，niosomes 是疏水性药物的良好给药系统，可增加其皮肤渗透性。Niosomal 凝胶可增加配方的稳定性，进一步提高药物渗透性，实现控释给药。文献调查显示，橄榄油、杏仁油或芥子油等精油可作为药物的天然渗透促进剂，用于三萜凝胶配方。
{"title":"A Review on Formulation Aspects of Niosomal Gel of Ellagic Acid using Natural Penetration Enhancers","authors":"Vaibhav V. Kakade, Ravindra B. Laware","doi":"10.52711/0975-4377.2024.00011","DOIUrl":"https://doi.org/10.52711/0975-4377.2024.00011","url":null,"abstract":"Ellagic acid, a polyphenolic compound present in fruits and berries, with wide spectrum of therapeutic and prophylactic activities. It has wide spectrum of therapeutic, prophylactic and nutritional activities. It is traditionally being used for cosmetic and therapeutic purposes for treating hyperpigmentation, skin cancer and many other skin ailments. Unfortunately Ellagic acid suffers from disadvantages of poor solubility, stability, bioavailability, first pass effect and inter subject variability in gut metabolism. This put serious limit over its use as a therapeutic agent. Recently a focus is being made on improving EA delivery to the site of action using various novel drug delivery systems. Presenting EA topically in vesicular drug delivery as niosomes using natural penetration enhancer as almond oil or olive oil can improve its water solubility and transdermal penetration. It was also learned during literature survey that niosomes act as a good delivery system for hydrophobic drug and serve to increase their dermal penetration. Niosomal gel increases formulation stability and offer to increase drug penetration further and achieve controlled release drug delivery. Literature survey revealed that essential oils as olive, almond or mustard oil act as good natural penetration enhancer for drug in trasndermal gel formulation.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140439131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-22DOI: 10.52711/0975-4377.2024.00018
Shubham Kanawade, Vaishnavi Jagdale, Ashutosh Shinde, Divyesh Poojari, H. Pawar
Nanoemulsions have emerged as a revolutionary technology in the realm of pharmaceutical formulations, holding immense promise to transform therapeutic outcomes. This comprehensive review delves into the intricate world of nanoemulsions, highlighting their pivotal role in advancing medication delivery systems. Researchers and pharmaceutical scientists are driven by the prospect of maximizing the efficacy of diverse medicinal compounds through the strategic incorporation of nanoemulsions. These finely tuned liquid-in-liquid dispersions, characterized by nanoscale droplets (approximately 100 nm), induce transformative effects. The resulting increase in surface area per unit volume and enhanced drug solubility pave the way for refining pharmaceutical formulations. Within this exploration, we delve into the latest advancements and methodologies shaping nanoemulsion creation. Novel strategies for precise drug delivery, heightened bioavailability, and reduced side effects are carefully examined. This review emphasizes the paramount significance of nanoemulsion technology in shaping the landscape of pharmaceutical formulations. By elevating therapeutic efficacy, nanoemulsions emerge as a critical tool for optimizing drug delivery systems, presenting a pathway to more effective and patient-friendly pharmaceutical solutions. The convergence of nanoemulsion technology and pharmaceutical innovation holds promise for advancing the future of therapeutic interventions.
{"title":"Review on Nanoemulsion Technology: A Formulation for Enhanced Therapeutic Efficacy","authors":"Shubham Kanawade, Vaishnavi Jagdale, Ashutosh Shinde, Divyesh Poojari, H. Pawar","doi":"10.52711/0975-4377.2024.00018","DOIUrl":"https://doi.org/10.52711/0975-4377.2024.00018","url":null,"abstract":"Nanoemulsions have emerged as a revolutionary technology in the realm of pharmaceutical formulations, holding immense promise to transform therapeutic outcomes. This comprehensive review delves into the intricate world of nanoemulsions, highlighting their pivotal role in advancing medication delivery systems. Researchers and pharmaceutical scientists are driven by the prospect of maximizing the efficacy of diverse medicinal compounds through the strategic incorporation of nanoemulsions. These finely tuned liquid-in-liquid dispersions, characterized by nanoscale droplets (approximately 100 nm), induce transformative effects. The resulting increase in surface area per unit volume and enhanced drug solubility pave the way for refining pharmaceutical formulations. Within this exploration, we delve into the latest advancements and methodologies shaping nanoemulsion creation. Novel strategies for precise drug delivery, heightened bioavailability, and reduced side effects are carefully examined. This review emphasizes the paramount significance of nanoemulsion technology in shaping the landscape of pharmaceutical formulations. By elevating therapeutic efficacy, nanoemulsions emerge as a critical tool for optimizing drug delivery systems, presenting a pathway to more effective and patient-friendly pharmaceutical solutions. The convergence of nanoemulsion technology and pharmaceutical innovation holds promise for advancing the future of therapeutic interventions.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140441116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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