Association of genetic polymorphisms of folate cycle enzymes with risk of pregnancy complications

Abstract

Polymorphisms in the genes of folate cycle enzymes are considered as the main cause of reduced plasma levels of folate and vitamin B12, impaired homocysteine metabolism, and the development of pregnancy complications. Objective. To study the association of polymorphism in folate cycle enzyme genes, MTHFR-677C>T, MTHFR-1298A>C, MTR‑2756A>G, MTRR-66A>G, with the risk of pregnancy complications. Patients and methods. The study was conducted in outpatient settings and included 96 women aged between 20 and 40 years with a history of 1 to 3 pregnancies who applied for preconception care. Results. When examining the association between the presence of a complicated history in this group of women and folate cycle enzyme gene polymorphisms using the Fisher test, a statistically significant correlation was detected for MTHFR-677C>T, MTHFR-1298A>C, MTR-2756A>G, and MTRR-66A>G. Conclusion. The presence/absence of genetic polymorphisms of folate cycle enzymes should be considered when predicting the risks of pregnancy complications and developing a personalized preconception care program to select individual regimens of folate supplementation. Key words: genes, folate cycle, polymorphism, folates, pregnancy