In vivo study using Amygdalin against mammalian tumors in a mice model

Ibrahim Abdelwadoud, Afaf eldesoky, Elsayed Salem
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Abstract

Keywords The present study aimed to evaluate the positive effects of amygdalin against mammalian tumors in vivo . Twenty female albino mice, 4-6 weeks old age, were equally divided into four groups: group I (control) received no drugs; group II (carcinogenic group) received oral 7,12-dimethylbenz[a]anthracene (DMBA) (50 mg/kg b.wt. once a weak) dissolved in sesame oil for 4 weeks; group III (treatment group) received oral amygdalin (0.6 mg/kg b.wt./day) dissolved in 100% corn oil for 4 weeks after DMBA-induced tumor as in group II; group IV (protection group) received amygdalin as in group III prior DMBA administration. The results showed that DMBA-induced mammalian tumors caused a significant increase in serum bilirubin (total and direct). Still, a substantial decrease in serum albumin as a hepatic function was recorded. Serum uric acid as a kidney marker revealed an insignificant increase. In addition, mammalian tissue L-malondialdehyde (L-MDA) concentration showed substantial and a considerable decrease in mammalian tissue total antioxidant capacity (TAC) concentration compared with the control group. However, the administration of amygdalin was able to mitigate DMBA-induced mammalian tumors through decreasing total and direct bilirubin, uric acid concentration, as well as L-MDA concentration, along with a significant increase of TAC concentration in mammalian tissue. Additionally, hematological parameters of amygdalin-administrated mice showed a substantial increase compared to mice with mammalian tumors induced by DMBA. Thus, it can be concluded that amygdalin may successfully protect mammary tumors.
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