Evaluation of Antiproliferative activity of Taxol, Proanthocyanidin and Atorvastatin against human hepatocellular carcinoma cell line (HepG2).

Abstract

Keywords Liver cancer is the sixth most frequent cancer in the world, with a significant morbidity and mortality rate, is liver cancer. Discovery of a suitable therapeutic alternative for this disease is of greatest importance because various types of cancer annually result in thousands of fatalities worldwide. Atorvastatin is a competitive inhibitor of hydroxy methylglutaryl CoA reductase, which plays a role in anticancer activities in a range of malignancies, including human liver cancer. Proanthocynadin is a phytochemical that has a variety of pharmacological effects and chemotherapeutic properties. Taxol, an anti-microtubule chemotherapeutic medication, has been shown to be effective in the treatment of several HepG2 (liver carcinoma cell line). In this study, the antiproliferative and proapoptotic properties of Atorvastatin, Proanthocynadin and Taxol against HepG2 liver cancer cell line was evaluated in vitro. Cell survival and apoptosis in liver cancer cell lines were analyzed using MTT assay. The results showed that Taxol, Atorvastatin and Proanthcyanidin inhibited the viability of HepG2 cells in a time-and dose-dependent manner, induced a significant enhancement of treated cancer cells compared to untreated cells. Hepatocellular