Investigating the Relationship between Type 2 Diabetes and Helicobacter Pylori

Abstract

Introduction: Helicobacter pylori infection is known as one of the health problems in the world, and the concurrent infection of diabetics with Helicobacter pylori contributes to health and economic problems in the world. The present study was conducted to investigate the prevalence of Helicobacter pylori in patients with type 2 diabetes in Gonabad City, Iran. Methods: This case-control study was conducted in Gonabad City, Iran. The number of participants in the study was 168. The method was simple random sampling and the study population was typing 2 diabetic and non-diabetic people who were referred to Gonabad health centers. After obtaining informed consent from the patients, 4 milliliters of venous blood were collected from the patients with type 2 diabetes and the control group, and IgG antibodies against Helicobacter pylori and Fasting Blood Sugar and Glycosylated Hemoglobin (HbA1C) were measured by ELISA and Colorimetric method, respectively. After entering the data into SPSS version 16 software, they were analyzed using independent tests, chi-square tests, and logistic regression tests. Results: In the present study, 71.4% of type 2 diabetes patients had IgG antibodies against H. pylori bacteria. The odds ratio of diabetes in the patients with positive IgG was 1.37 times that of patients with negative IgG, and this relationship was statistically significant (P=0.003). Conclusion: The present study showed that H. pylori was more common in diabetic patients than non-diabetic ones, and in diabetic patients, there was no statistically significant relationship between the duration of diabetes, family history of diabetes, and smoking history with Helicobacter pylori infection.