Pub Date : 2024-07-27DOI: 10.18502/ssu.v32i5.16124
Fatemeh Mehravar, Mohammad Khodabakhsh, Hamed Salehi, Roqayeh Hakimian, Monireh Sadoughi
Introduction: Due to the importance of preserving baby teeth, it is necessary for parents to have correct information about dental services for these teeth, the present study was conducted with the aim of investigating the acceptance of suggested treatments for baby teeth by parents. Methods: In this descriptive-cross-sectional study, 218 parents of children under 12 years old who were referred to the Pediatric Dentistry Department of Yazd Faculty of Dentistry in 2022 were randomly included in this study. The acceptance rate of dental treatments was asked by a checklist with 7 comprehensive questions and the answers were recorded. Data were analyzed using SPSS version 16 and Chi-square statistical test. Results: Out of 218 parents who participated in this study, 38 (17.4%) were male and 180 (82.6%) were female. The most acceptable treatments by parents were: pulp treatment (98.6%), dental radiographs (97.7%), tooth extraction (97.2%) and stainless-steel crowns (95%). The lowest rate of acceptance was for general anesthesia (23.4 %), fissure sealant (30.7 %) and sedation technique (36.2 %), respectively. Acceptance of fluoride gel and sedation by mothers was significantly higher than fathers (P <0.05). No statistically significant difference was observed in terms of the age and gender of the child with the acceptance of treatment by their parents (P<0.05). Conclusion: Based on the findings of the present study, the most and the least acceptable treatments according to parents were pulp therapy and general anesthesia services, respectively. Parents' level of education, monthly income, child's age،, and gender did not have a significant impact on parents' acceptance of treatment.
{"title":"Parental Acceptance of Dental Treatment Options for Primary Teeth","authors":"Fatemeh Mehravar, Mohammad Khodabakhsh, Hamed Salehi, Roqayeh Hakimian, Monireh Sadoughi","doi":"10.18502/ssu.v32i5.16124","DOIUrl":"https://doi.org/10.18502/ssu.v32i5.16124","url":null,"abstract":"Introduction: Due to the importance of preserving baby teeth, it is necessary for parents to have correct information about dental services for these teeth, the present study was conducted with the aim of investigating the acceptance of suggested treatments for baby teeth by parents. \u0000Methods: In this descriptive-cross-sectional study, 218 parents of children under 12 years old who were referred to the Pediatric Dentistry Department of Yazd Faculty of Dentistry in 2022 were randomly included in this study. The acceptance rate of dental treatments was asked by a checklist with 7 comprehensive questions and the answers were recorded. Data were analyzed using SPSS version 16 and Chi-square statistical test. \u0000Results: Out of 218 parents who participated in this study, 38 (17.4%) were male and 180 (82.6%) were female. The most acceptable treatments by parents were: pulp treatment (98.6%), dental radiographs (97.7%), tooth extraction (97.2%) and stainless-steel crowns (95%). The lowest rate of acceptance was for general anesthesia (23.4 %), fissure sealant (30.7 %) and sedation technique (36.2 %), respectively. Acceptance of fluoride gel and sedation by mothers was significantly higher than fathers (P <0.05). No statistically significant difference was observed in terms of the age and gender of the child with the acceptance of treatment by their parents (P<0.05). \u0000Conclusion: Based on the findings of the present study, the most and the least acceptable treatments according to parents were pulp therapy and general anesthesia services, respectively. Parents' level of education, monthly income, child's age،, and gender did not have a significant impact on parents' acceptance of treatment.","PeriodicalId":17084,"journal":{"name":"Journal of Shahid Sadoughi University of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141797614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-27DOI: 10.18502/ssu.v32i5.16119
Majid Marzban Sarnaghi, Deniz Farzad, Reza Gholikhani Darbroud, Zafar Gholinejad
Introduction: Human genome consists of the three billion base pairs that has about one percent of genetic variation from one person to another، which determines physical، psychological، and susceptibility to diseases. Among the types of genetic diversity, single nucleotide polymorphisms are one of the most important genetic differences between two people. Single nucleotide polymorphism variation is located in the promoter region, exons، introns، untranslated regions and other Deoxyribonucleic acid (DNA) regions. While variation in the exon region can change susceptibility to diseases depending on whether it changes the protein structure or affects translation kinetics. Diversity in the promoter region can affect the interaction of genetic and epigenetic elements. Also، variation in the promoter region can affect the DNA methylation status. Polymorphic variation in the intron region can affect Messenger Ribonucleic acid splicing and the function of cis-regulatory elements. Polymorphic variation in the 5' Untranslated region، region causes a change in translation efficiency,، while a change in the 3' Untranslated region binds micro Ribonucleic acids to their position then affects the effects. In some cases، variations in Transfer Ribonucleic acid (tRNA) and Ribosomal ribonucleic acid (rRNA) affect the function of these regulatory cis elements. Conclusion: From a clinical point of view, a deep knowledge of this type of genetic variation can help the treatment process, manage patients and understand the prognosis based on these SNPs. Private or personalized medicine is also fundamentally based on genetic diversity. In this article, it was reviewed the types of single nucleotide genetic variation and presented examples of types of cancer, neurological and immunological diseases.
引言人类基因组由 30 亿个碱基对组成，人与人之间的遗传变异约占百分之一。在遗传多样性中，单核苷酸多态性是两个人之间最重要的遗传差异之一。单核苷酸多态性变异位于启动子区、外显子区、内含子区、非翻译区和其他脱氧核糖核酸（DNA）区。外显子区的变异会改变对疾病的易感性，这取决于它是否会改变蛋白质结构或影响翻译动力学。启动子区域的多样性会影响遗传和表观遗传元素的相互作用。此外，启动子区域的变异也会影响 DNA 甲基化状态。内含子区的多态性变异会影响信使核糖核酸的剪接和顺式调节元件的功能。5'非翻译区的多态性变异会导致翻译效率的改变，而3'非翻译区的变异则会使微核糖核酸与其位置结合，进而影响其效果。在某些情况下，转运核糖核酸（tRNA）和核糖体核糖核酸（rRNA）的变化会影响这些顺式元件的功能。结论从临床角度看，深入了解这类基因变异有助于治疗过程、管理患者和了解基于这些 SNPs 的预后。私人或个性化医疗也从根本上建立在基因多样性的基础上。本文回顾了单核苷酸基因变异的类型，并举例说明了癌症、神经和免疫疾病的类型。
{"title":"Single Nucleotide Polymorphisms: A Deep Consideration of Protein Sequence Variation","authors":"Majid Marzban Sarnaghi, Deniz Farzad, Reza Gholikhani Darbroud, Zafar Gholinejad","doi":"10.18502/ssu.v32i5.16119","DOIUrl":"https://doi.org/10.18502/ssu.v32i5.16119","url":null,"abstract":"Introduction: Human genome consists of the three billion base pairs that has about one percent of genetic variation from one person to another، which determines physical، psychological، and susceptibility to diseases. Among the types of genetic diversity, single nucleotide polymorphisms are one of the most important genetic differences between two people. Single nucleotide polymorphism variation is located in the promoter region, exons، introns، untranslated regions and other Deoxyribonucleic acid (DNA) regions. While variation in the exon region can change susceptibility to diseases depending on whether it changes the protein structure or affects translation kinetics. Diversity in the promoter region can affect the interaction of genetic and epigenetic elements. Also، variation in the promoter region can affect the DNA methylation status. Polymorphic variation in the intron region can affect Messenger Ribonucleic acid splicing and the function of cis-regulatory elements. Polymorphic variation in the 5' Untranslated region، region causes a change in translation efficiency,، while a change in the 3' Untranslated region binds micro Ribonucleic acids to their position then affects the effects. In some cases، variations in Transfer Ribonucleic acid (tRNA) and Ribosomal ribonucleic acid (rRNA) affect the function of these regulatory cis elements. \u0000Conclusion: From a clinical point of view, a deep knowledge of this type of genetic variation can help the treatment process, manage patients and understand the prognosis based on these SNPs. Private or personalized medicine is also fundamentally based on genetic diversity. In this article, it was reviewed the types of single nucleotide genetic variation and presented examples of types of cancer, neurological and immunological diseases.","PeriodicalId":17084,"journal":{"name":"Journal of Shahid Sadoughi University of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141798445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-27DOI: 10.18502/ssu.v32i5.16122
J. Yaghini, Narges Naghsh, Reyhane Naghdi Badi
Introduction: Sleep disorders can affect on different organs and increase the risk of cardiovascular disease, diabetes, depression, immunity disorders and decrease the bone density. Periodontitis includes inflammation of periodontium because of increased or decreased response of the host immunity to predisposing factors (it can be in presence of systemic diseases). The aim of this study was to evaluate the relationship between sleep disorders and periodontal diseases. Methods: In this analytic-cross sectional study, 60 individuals clinically healthy that referring to Department of Periodontology of Isfahan Dental School at year 2018-19 categorized into 2 groups: with or without dyssomnias (with PSQI questionnaire). In this study, Sillness and Loe plaque index, Loe and Sillness gingival index and calculus index were investigated. Similarly assessed demographic factors, personal health behaviors and relation between the severity of periodontitis and dyssomnia and were assessed. Data analyzed by SPSS statistics 16 software using independent T-test, Mann-Whitney, Pearson and multinominal regression. Results: Severity of periodontitis had a significant relationship with age, BMI (Body Mass Index), calculus index, frequency of flossing and brushing as well as score of PSQI questionnaire (p<0.5). By controlling age, gender, mass and plaque index, there was a significant relationship between dyssomnias and severity of periodontal disease in the patients with moderate periodontitis (P>0.001) and severe periodontitis (P=0.006), but in the case of mild periodontitis, the relationship was close to the significant level (p=0.087). Conclusion: It seems that dyssomnias is in relation to severity of periodontitis; therefore sleep hygiene may help controlling periodontal diseases. However more studies are needed in this field.
{"title":"Comparative Evaluation of Severity of Periodontitis in Patients with and without Dyssomnias","authors":"J. Yaghini, Narges Naghsh, Reyhane Naghdi Badi","doi":"10.18502/ssu.v32i5.16122","DOIUrl":"https://doi.org/10.18502/ssu.v32i5.16122","url":null,"abstract":"Introduction: Sleep disorders can affect on different organs and increase the risk of cardiovascular disease, diabetes, depression, immunity disorders and decrease the bone density. Periodontitis includes inflammation of periodontium because of increased or decreased response of the host immunity to predisposing factors (it can be in presence of systemic diseases). The aim of this study was to evaluate the relationship between sleep disorders and periodontal diseases. \u0000Methods: In this analytic-cross sectional study, 60 individuals clinically healthy that referring to Department of Periodontology of Isfahan Dental School at year 2018-19 categorized into 2 groups: with or without dyssomnias (with PSQI questionnaire). In this study, Sillness and Loe plaque index, Loe and Sillness gingival index and calculus index were investigated. Similarly assessed demographic factors, personal health behaviors and relation between the severity of periodontitis and dyssomnia and were assessed. Data analyzed by SPSS statistics 16 software using independent T-test, Mann-Whitney, Pearson and multinominal regression. \u0000Results: Severity of periodontitis had a significant relationship with age, BMI (Body Mass Index), calculus index, frequency of flossing and brushing as well as score of PSQI questionnaire (p<0.5). By controlling age, gender, mass and plaque index, there was a significant relationship between dyssomnias and severity of periodontal disease in the patients with moderate periodontitis (P>0.001) and severe periodontitis (P=0.006), but in the case of mild periodontitis, the relationship was close to the significant level (p=0.087). \u0000Conclusion: It seems that dyssomnias is in relation to severity of periodontitis; therefore sleep hygiene may help controlling periodontal diseases. However more studies are needed in this field.","PeriodicalId":17084,"journal":{"name":"Journal of Shahid Sadoughi University of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141797659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Personality traits are the basis of stable patterns and emotional and behavioral functioning that affect the risk of contracting chronic diseases and people's ways of understanding health. The purpose of this study was to evaluate the personality traits between cardiovascular patients and the individuals with a history of drug abuse. Methods: The present study was an analytical cross-sectional study on 301 individuals (115 control group, 86 cardiovascular patients and 100 individuals with a history of drug addiction) in the form of convenience and available sampling in Karaj City in 2023. The data were collected using the ZKA personality questionnaire. After collecting the data, they were entered into SPSS version16 software. Independent t-tests, one-way analysis of variance were used for data analysis. Results: In the present study, the mean and standard deviation of the total age of the participants was 41.37±14.76. The participation consisted of 179 (59.4%) men and 122 (39.6%) women. In SS1, EX2, AC4, AG2, NE4, SS4, and EX3 aspects, statistically significant differences were observed between the groups of cardiovascular and the control. In the aspects of AC4, AG2, NE4, EX2, NE2, SS4 and NE and SS factors, a significant difference was observed between the individuals with a history of addiction and the control group. Conclusion: Considering the relationship between personality traits and heart diseases and substance abuse, it is recommended that the results of this study be considered for prevention and appropriate intervention by doctors and health professionals, and these results can also be used to develop treatment programs.
引言人格特质是稳定模式、情绪和行为功能的基础，会影响罹患慢性疾病的风险以及人们对健康的理解方式。本研究旨在评估心血管病患者与有药物滥用史者之间的人格特质。研究方法本研究是一项分析性横断面研究，研究对象为 2023 年卡拉杰市的 301 人（115 名对照组、86 名心血管病患者和 100 名有吸毒史者），采用方便抽样和可获得抽样的形式。数据使用 ZKA 人格问卷收集。收集数据后，将其输入 SPSS 16 版软件。数据分析采用独立 t 检验和单因素方差分析。结果本研究中，参与者总年龄的平均值和标准差为（41.37±14.76）岁。其中男性 179 人（59.4%），女性 122 人（39.6%）。在 SS1、EX2、AC4、AG2、NE4、SS4 和 EX3 方面，心血管病组与对照组之间存在显著的统计学差异。在 AC4、AG2、NE4、EX2、NE2、SS4 以及 NE 和 SS 因子方面，有成瘾史者与对照组之间存在显著差异。结论考虑到人格特质与心脏病和药物滥用之间的关系，建议医生和卫生专业人员在预防和适当干预时考虑本研究的结果，这些结果也可用于制定治疗方案。
{"title":"Evaluation of the Personality Characteristics of Cardiovascular Patients and People with a History of Drug abuse with the Control Group","authors":"Meysam Farezi, Morteza Eshaghi, Nasrin Panbezan, Vahideh Mansouri, Nafiseh Rostami, Samad Darabian","doi":"10.18502/ssu.v32i5.16125","DOIUrl":"https://doi.org/10.18502/ssu.v32i5.16125","url":null,"abstract":"Introduction: Personality traits are the basis of stable patterns and emotional and behavioral functioning that affect the risk of contracting chronic diseases and people's ways of understanding health. The purpose of this study was to evaluate the personality traits between cardiovascular patients and the individuals with a history of drug abuse. \u0000Methods: The present study was an analytical cross-sectional study on 301 individuals (115 control group, 86 cardiovascular patients and 100 individuals with a history of drug addiction) in the form of convenience and available sampling in Karaj City in 2023. The data were collected using the ZKA personality questionnaire. After collecting the data, they were entered into SPSS version16 software. Independent t-tests, one-way analysis of variance were used for data analysis. \u0000Results: In the present study, the mean and standard deviation of the total age of the participants was 41.37±14.76. The participation consisted of 179 (59.4%) men and 122 (39.6%) women. In SS1, EX2, AC4, AG2, NE4, SS4, and EX3 aspects, statistically significant differences were observed between the groups of cardiovascular and the control. In the aspects of AC4, AG2, NE4, EX2, NE2, SS4 and NE and SS factors, a significant difference was observed between the individuals with a history of addiction and the control group. \u0000Conclusion: Considering the relationship between personality traits and heart diseases and substance abuse, it is recommended that the results of this study be considered for prevention and appropriate intervention by doctors and health professionals, and these results can also be used to develop treatment programs.","PeriodicalId":17084,"journal":{"name":"Journal of Shahid Sadoughi University of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141797994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Ketamine is a general anesthetic drug that acts by inhibiting the NMDA receptoran important component of excitatory neurotransmission. Existing of NMDA receptors all over the central nervous system and the special type of anesthesia induced by ketamine, called dissociative anesthesia has led to its use as an analgesic and also paved the way for abuse. Ketamine affects the cardiovascular system by increasing indices such as heart rate, blood pressure, and cardiac output. Methods: For further evaluation of ketamine effects on heart tissue, we used 15 male and 15 female Wistar rats and divided them into 6 groups, including male and female control groups (MC and FC), male and female short-term exposure (MS and FS), and male and female long-term exposure (ML and FL) to ketamine. Each group included 5 Wistar rats. The ML and FL groups received 75mg of ketamine once a week for 4 weeks in the posterior muscle of the thigh and the MS and FS groups received 25mg of ketamine 3 times a week for 4 weeks at the same site. Results: After preparation of histopathological slides, it was observed that only in the group of female mice receiving long-term ketamine, empty spaces and intercellular distances increased, and in the group of male mice receiving long-term ketamine, in addition to the increase of intercellular spaces, tissue accumulations were also observed in the heart tissue. Conclusion: This study showed that long-term ketamine injection in both sexes can cause some qualitative changes in heart tissue. Expanding the duration of long-term exposure to ketamine and more studies based on sexes can lead to more findings.
{"title":"Evaluating the Histopathological Effects of Short-term and Long-term Doses of Ketamine Injection on Heart Tissue of Male and Female Rats","authors":"B. Yahyaei, Faeze Gholipour, Leila Khojasteh, Mohammadbagher Gilak Hakimabadi, Fatemeh Bahoosh Feyzabadi, Fatemeh Dankoub, Melika Nasehi","doi":"10.18502/ssu.v32i5.16121","DOIUrl":"https://doi.org/10.18502/ssu.v32i5.16121","url":null,"abstract":"Introduction: Ketamine is a general anesthetic drug that acts by inhibiting the NMDA receptoran important component of excitatory neurotransmission. Existing of NMDA receptors all over the central nervous system and the special type of anesthesia induced by ketamine, called dissociative anesthesia has led to its use as an analgesic and also paved the way for abuse. Ketamine affects the cardiovascular system by increasing indices such as heart rate, blood pressure, and cardiac output. \u0000Methods: For further evaluation of ketamine effects on heart tissue, we used 15 male and 15 female Wistar rats and divided them into 6 groups, including male and female control groups (MC and FC), male and female short-term exposure (MS and FS), and male and female long-term exposure (ML and FL) to ketamine. Each group included 5 Wistar rats. The ML and FL groups received 75mg of ketamine once a week for 4 weeks in the posterior muscle of the thigh and the MS and FS groups received 25mg of ketamine 3 times a week for 4 weeks at the same site. \u0000Results: After preparation of histopathological slides, it was observed that only in the group of female mice receiving long-term ketamine, empty spaces and intercellular distances increased, and in the group of male mice receiving long-term ketamine, in addition to the increase of intercellular spaces, tissue accumulations were also observed in the heart tissue. \u0000Conclusion: This study showed that long-term ketamine injection in both sexes can cause some qualitative changes in heart tissue. Expanding the duration of long-term exposure to ketamine and more studies based on sexes can lead to more findings.","PeriodicalId":17084,"journal":{"name":"Journal of Shahid Sadoughi University of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141798485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-27DOI: 10.18502/ssu.v32i5.16120
Elahe Davoudi, M. Nezhadali, Saba Taheri
Introduction: Non-alcoholic fatty liver disease (NAFLD) is a major global health problem, in which liver fat exceeds 5% of the liver weight, without secondary causes of fat accumulation or excessive alcohol consumption. Resistin plays a key role in energy homeostasis, insulin resistance, inflammation, and metabolic disorders. This study aimed to investigate the relationship between resistin (RETN) level and NAFLD. Methods: In this cross-sectional study, 80 patients with NAFLD and 80 healthy individuals as controls were evaluated. Biochemical variables, liver enzymes, insulin, and resistin were measured. Data were analyzed using SPSS version 16 software. Results: The variables of cholesterol, insulin, triglyceride, HDL, body mass index, age, and liver enzymes were significantly different between the two groups of patients with NAFLD and healthy individuals (p<0.05). In patients, resistin was associated with triglyceride (r=0.243, p=0.045). No association was found between resistin level and NAFLD grades (p≥0.05). Conclusion: The results of this study indicate that there is a relationship between resistin and NAFLD. There is no association between resistin level and the degree of NAFLD.
{"title":"Serum Resistin Levels in Patients with Nonalcoholic Fatty Liver Disease in an Iranian Population","authors":"Elahe Davoudi, M. Nezhadali, Saba Taheri","doi":"10.18502/ssu.v32i5.16120","DOIUrl":"https://doi.org/10.18502/ssu.v32i5.16120","url":null,"abstract":"Introduction: Non-alcoholic fatty liver disease (NAFLD) is a major global health problem, in which liver fat exceeds 5% of the liver weight, without secondary causes of fat accumulation or excessive alcohol consumption. Resistin plays a key role in energy homeostasis, insulin resistance, inflammation, and metabolic disorders. This study aimed to investigate the relationship between resistin (RETN) level and NAFLD. \u0000Methods: In this cross-sectional study, 80 patients with NAFLD and 80 healthy individuals as controls were evaluated. Biochemical variables, liver enzymes, insulin, and resistin were measured. Data were analyzed using SPSS version 16 software. \u0000Results: The variables of cholesterol, insulin, triglyceride, HDL, body mass index, age, and liver enzymes were significantly different between the two groups of patients with NAFLD and healthy individuals (p<0.05). In patients, resistin was associated with triglyceride (r=0.243, p=0.045). No association was found between resistin level and NAFLD grades (p≥0.05). \u0000Conclusion: The results of this study indicate that there is a relationship between resistin and NAFLD. There is no association between resistin level and the degree of NAFLD.","PeriodicalId":17084,"journal":{"name":"Journal of Shahid Sadoughi University of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141797938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-27DOI: 10.18502/ssu.v32i5.16123
Shakiba Ghani Dehkordi, F. Shabkhiz, R. Soori, F. Amirshaghaghi
Introduction: NRF2 and NQO1 proteins are very important for cell protection; Therefore, the purpose of this research was investigating the effect of resistance training with coenzyme Q10 supplementation on the content of NRF2 and NQO1 proteins in the hippocampus of male Sprague-Dawley rats. Methods: In this experimental study, thirty-two 2-month-old Sprague-Dawley rats with an average weight of 200±20 gr were selected. Rats were randomly divided into four groups: 1-control, 2-resistance training, 3-resistance training+Q10 supplement and 4-Q10 supplement. The resistance training program consisted of climbing a ladder with 26 steps and a slope of 85 degrees, for 8 weeks and 3 sessions every week. The daily consumption of Q10 supplement was 200 mg/kg of body weight of rats. The content of proteins was measured through Western-Blot laboratory method. Data analysis was done by one-way ANOVA and Tukey's post hoc tests and the effect size of eta squared test using SPSS version 16 and Graphpad Prism software version 10.2.3. The significance level was P≤0.05. Results: Eight weeks of resistance training with Q10 supplementation led to a significant change in NRF2 content (F=4.80, p≤0.03, ƞ2=0.64). Tukey's post hoc test showed this significant change between pairs of resistance training groups and Q10 supplement group (p≤0.04); medium effect size was observed in NRF2 content (ƞ2=0.64). No significant difference was observed in NQO1 content (F=3.01, p≤0.09, ƞ2=0.33). A weak effect size was observed in NQO1 content (ƞ2=0.33). Conclusion: Doing resistance training together with Q10 supplementation alone or in combination cannot significantly change the content of NRF2 and NQO1 proteins in the hippocampus of the brain.
{"title":"Effect of Resistance Training with Coenzyme Q10 Supplementation on the Intracellular Content of NRF2 and NQO1 Proteins in the Hippocampal Tissue of Male Sprague-Dawley Rats","authors":"Shakiba Ghani Dehkordi, F. Shabkhiz, R. Soori, F. Amirshaghaghi","doi":"10.18502/ssu.v32i5.16123","DOIUrl":"https://doi.org/10.18502/ssu.v32i5.16123","url":null,"abstract":"Introduction: NRF2 and NQO1 proteins are very important for cell protection; Therefore, the purpose of this research was investigating the effect of resistance training with coenzyme Q10 supplementation on the content of NRF2 and NQO1 proteins in the hippocampus of male Sprague-Dawley rats. \u0000Methods: In this experimental study, thirty-two 2-month-old Sprague-Dawley rats with an average weight of 200±20 gr were selected. Rats were randomly divided into four groups: 1-control, 2-resistance training, 3-resistance training+Q10 supplement and 4-Q10 supplement. The resistance training program consisted of climbing a ladder with 26 steps and a slope of 85 degrees, for 8 weeks and 3 sessions every week. The daily consumption of Q10 supplement was 200 mg/kg of body weight of rats. The content of proteins was measured through Western-Blot laboratory method. Data analysis was done by one-way ANOVA and Tukey's post hoc tests and the effect size of eta squared test using SPSS version 16 and Graphpad Prism software version 10.2.3. The significance level was P≤0.05. \u0000Results: Eight weeks of resistance training with Q10 supplementation led to a significant change in NRF2 content (F=4.80, p≤0.03, ƞ2=0.64). Tukey's post hoc test showed this significant change between pairs of resistance training groups and Q10 supplement group (p≤0.04); medium effect size was observed in NRF2 content (ƞ2=0.64). No significant difference was observed in NQO1 content (F=3.01, p≤0.09, ƞ2=0.33). A weak effect size was observed in NQO1 content (ƞ2=0.33). \u0000Conclusion: Doing resistance training together with Q10 supplementation alone or in combination cannot significantly change the content of NRF2 and NQO1 proteins in the hippocampus of the brain. \u0000 ","PeriodicalId":17084,"journal":{"name":"Journal of Shahid Sadoughi University of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141798446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-27DOI: 10.18502/ssu.v32i5.16118
Pegah Shayegh, Farzaneh Rahmati, Fatemeh Baniasadi, Meisam Jangkhah, Hasan Rajabimaham, M. Ghalamboran, Rouhollah Fathi
Introduction: To assist save endangered species from extinction and to aid in their care, it is crucial to sustaining their reproductive capacity. The fetus's life and growth processes begin at conception and proceed in accordance with a biological clock's timing. With today's understanding through cryobiology, observing scientific ethics problems and interfering with the clock's operation by stopping its biological time is possible. Practically, it is accomplished by storing the cell at -196 °C, or the temperature of liquid nitrogen, where all metabolic activity ceases. Since 200 years ago, germ cell preservation has been a common practice. Since then, there have been many improvements, particularly for at-risk women. Since then, significant progress has been achieved, and several freezing techniques are being used to preserve ovarian tissue, follicles, and oocytes in women who are at risk of infertility. Different approaches have different levels of success. Among preservation techniques, vitrification performs better and is used more frequently. The cellular configuration of the mammalian oocyte is intricate. This cell's constituent parts are particularly sensitive to osmosis and variations in temperature. For instance, the alterations to the cell membrane that occur during maturation, in vitro fertilization, and the differential between the permeability of water and cryoprotectants can all be mentioned. Oocyte freezing results in a variety of impairments, including a reduction in the quality and viability of cells after thawing. Recent studies are looking for ways to enhance freezing procedures and raise the caliber of frozen oocytes. The favorable or negative effects of freezing on the oocyte and its potential, or embryo development, are the subject of this review article.
{"title":"Damages of Freezing on the Development of Oocyte and Embryos","authors":"Pegah Shayegh, Farzaneh Rahmati, Fatemeh Baniasadi, Meisam Jangkhah, Hasan Rajabimaham, M. Ghalamboran, Rouhollah Fathi","doi":"10.18502/ssu.v32i5.16118","DOIUrl":"https://doi.org/10.18502/ssu.v32i5.16118","url":null,"abstract":"Introduction: To assist save endangered species from extinction and to aid in their care, it is crucial to sustaining their reproductive capacity. The fetus's life and growth processes begin at conception and proceed in accordance with a biological clock's timing. With today's understanding through cryobiology, observing scientific ethics problems and interfering with the clock's operation by stopping its biological time is possible. Practically, it is accomplished by storing the cell at -196 °C, or the temperature of liquid nitrogen, where all metabolic activity ceases. Since 200 years ago, germ cell preservation has been a common practice. Since then, there have been many improvements, particularly for at-risk women. Since then, significant progress has been achieved, and several freezing techniques are being used to preserve ovarian tissue, follicles, and oocytes in women who are at risk of infertility. Different approaches have different levels of success. Among preservation techniques, vitrification performs better and is used more frequently. The cellular configuration of the mammalian oocyte is intricate. This cell's constituent parts are particularly sensitive to osmosis and variations in temperature. For instance, the alterations to the cell membrane that occur during maturation, in vitro fertilization, and the differential between the permeability of water and cryoprotectants can all be mentioned. Oocyte freezing results in a variety of impairments, including a reduction in the quality and viability of cells after thawing. Recent studies are looking for ways to enhance freezing procedures and raise the caliber of frozen oocytes. The favorable or negative effects of freezing on the oocyte and its potential, or embryo development, are the subject of this review article.","PeriodicalId":17084,"journal":{"name":"Journal of Shahid Sadoughi University of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141797572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-24DOI: 10.18502/ssu.v32i2.15386
Mohsen Barghamadi, Ebrahim Piri
Introduction: The ankle joint is one of the most vulnerable joints in the body due to weight bearing. Pronated foot is one of the most common complications of the lower limbs. Therefore, the aim of the present study was to investigate the effect of training in water and training with thera-band on the frequency spectrum of electrical activity of lower limb muscles in people with pronated foot during walking. Methods: The present research was a clinical trial study that was conducted in a semi-experimental and laboratory. The statistical sample of the present study included 45 students of University of Mohaghegh Ardabili who had pronated foot, were selected purposefully and were randomly and equally placed in three groups: TheraBand, exercise in water, and control. The training protocol used for the water training group was based on the sports prescription guidelines of the American College of Sports Medicine (ACSM), and for the training group with the thera-band, it was performed using an orange thera-band in three sets with repetitions of 14 movements. To measure the frequency spectrum of the electrical activity of the lower limb muscles, it was recorded using a wireless surface electromyography device. Likewise, analysis of variance with repeated measurements and Bonferroni post hoc test were used to analyze the data at a significance level of P≤0.05. Results: The results showed that the interactive effect of time and group on the middle frequency spectrum of electromyography of the vastus medialis muscle in the exercises of the thera-band group during walking had a significant decrease (P=0.02). Other variables from the pre-test stage to the post-test did not show statistically significant differences (P<0.05). Conclusion: It seems that doing exercises in water and thera-band doesn't statistically have much effect on the frequency spectrum of the electrical activity of the lower limb muscles.
{"title":"Effect of Training in Water and Training with Thera-Band on the Frequency Spectrum of Electrical Activity of Lower Limb Muscles in People with Pronated Foot During Walking: A Clinical Trial Study","authors":"Mohsen Barghamadi, Ebrahim Piri","doi":"10.18502/ssu.v32i2.15386","DOIUrl":"https://doi.org/10.18502/ssu.v32i2.15386","url":null,"abstract":"Introduction: The ankle joint is one of the most vulnerable joints in the body due to weight bearing. Pronated foot is one of the most common complications of the lower limbs. Therefore, the aim of the present study was to investigate the effect of training in water and training with thera-band on the frequency spectrum of electrical activity of lower limb muscles in people with pronated foot during walking. \u0000Methods: The present research was a clinical trial study that was conducted in a semi-experimental and laboratory. The statistical sample of the present study included 45 students of University of Mohaghegh Ardabili who had pronated foot, were selected purposefully and were randomly and equally placed in three groups: TheraBand, exercise in water, and control. The training protocol used for the water training group was based on the sports prescription guidelines of the American College of Sports Medicine (ACSM), and for the training group with the thera-band, it was performed using an orange thera-band in three sets with repetitions of 14 movements. To measure the frequency spectrum of the electrical activity of the lower limb muscles, it was recorded using a wireless surface electromyography device. Likewise, analysis of variance with repeated measurements and Bonferroni post hoc test were used to analyze the data at a significance level of P≤0.05. \u0000Results: The results showed that the interactive effect of time and group on the middle frequency spectrum of electromyography of the vastus medialis muscle in the exercises of the thera-band group during walking had a significant decrease (P=0.02). Other variables from the pre-test stage to the post-test did not show statistically significant differences (P<0.05). \u0000Conclusion: It seems that doing exercises in water and thera-band doesn't statistically have much effect on the frequency spectrum of the electrical activity of the lower limb muscles.","PeriodicalId":17084,"journal":{"name":"Journal of Shahid Sadoughi University of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140660411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-24DOI: 10.18502/ssu.v32i2.15384
Fatemeh Ayatollahi, Alireza Abbasi, F. F. Ardakani, Elahe Khodarahmi
Introduction: Vital pulp therapy includes is differnt methods that are used to preserve pulp vitality and root development in immature permanent teeth with thin dentin wall and open apical foramen which have been damaged or inflamed due to dental caries, trauma, or during the restoration. This study was conducted to assess the knowledge of Yazd general dentists toward Vital pulp therapy in immature permanent teeth in 2022. Methods: In this descriptive-cross-sectional study, a valid and reliable questionnaire, including demographic information and 15 questions related to the knowledge of vital pulp therapy was distributed among 150 general dentists in Yazd City, Iran. Data were analyzed using SPSS-22 software, T-test and ANOVA. Results: The participants in this study, included 55.3% men and 44.7% women with an average age of 34.25 (±7.32) years old and an average years of job experience of 8.32 (±7.04). Among them, 35.3% had participated in dentistry retraining courses. The average knowledge score of the participants in this study was 9.2 out of 15. The average score in different groups did not show any significant difference in terms of age, sex, job experience, work place and participation in retraining courses. (P-value >0.05) Conclusion: Yazd general dentists had intermediate level of knowledge about the vital pulp therapy of immature permanent teeth. It seems that the need for retraining courses to improve the level of knowledge about vital pulp therapy to help choosing the best treatment plan for young permanent teeth is evident.
{"title":"Evaluation of Yazd General Dentists’ Knowledge about Vital Pulp Therapy in Immature Permanent Teeth in 2022","authors":"Fatemeh Ayatollahi, Alireza Abbasi, F. F. Ardakani, Elahe Khodarahmi","doi":"10.18502/ssu.v32i2.15384","DOIUrl":"https://doi.org/10.18502/ssu.v32i2.15384","url":null,"abstract":"Introduction: Vital pulp therapy includes is differnt methods that are used to preserve pulp vitality and root development in immature permanent teeth with thin dentin wall and open apical foramen which have been damaged or inflamed due to dental caries, trauma, or during the restoration. This study was conducted to assess the knowledge of Yazd general dentists toward Vital pulp therapy in immature permanent teeth in 2022. \u0000Methods: In this descriptive-cross-sectional study, a valid and reliable questionnaire, including demographic information and 15 questions related to the knowledge of vital pulp therapy was distributed among 150 general dentists in Yazd City, Iran. Data were analyzed using SPSS-22 software, T-test and ANOVA. \u0000Results: The participants in this study, included 55.3% men and 44.7% women with an average age of 34.25 (±7.32) years old and an average years of job experience of 8.32 (±7.04). Among them, 35.3% had participated in dentistry retraining courses. The average knowledge score of the participants in this study was 9.2 out of 15. The average score in different groups did not show any significant difference in terms of age, sex, job experience, work place and participation in retraining courses. (P-value >0.05) \u0000Conclusion: Yazd general dentists had intermediate level of knowledge about the vital pulp therapy of immature permanent teeth. It seems that the need for retraining courses to improve the level of knowledge about vital pulp therapy to help choosing the best treatment plan for young permanent teeth is evident. \u0000 ","PeriodicalId":17084,"journal":{"name":"Journal of Shahid Sadoughi University of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140662554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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