Real-world clinical efficacy of nemolizumab in Japanese patients with atopic dermatitis

Yoshinori Watanabe, Yozo Ishiuji, Minako Ogawa-Tominaga, Michie Katsuta, Akihiko Asahina
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Abstract

Nemolizumab was approved in Japan in August 2022 to treat patients with atopic dermatitis (AD). The study objective was to evaluate its effectiveness in controlling AD symptoms in the real world postmarketing. Eleven Japanese patients with AD treated with nemolizumab were assessed at 12 weeks for clinical manifestations, AD scores Visual Analog Scale and Eczema Area and Severity Index, and serum biomarkers. Visual Analog Scale and Eczema Area and Severity Index scores were significantly decreased by 80% and 66.4%, showing nemolizumab improved both itch and skin lesions. However, several serum AD biomarkers did not change during treatment with nemolizumab.
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奈莫单抗在日本特应性皮炎患者中的实际临床疗效
Nemolizumab于2022年8月在日本被批准用于治疗特应性皮炎(AD)患者。该研究的目的是评估其在上市后控制阿尔茨海默病症状的有效性。11名接受奈莫单抗治疗的日本AD患者在12周时进行临床表现、AD评分、视觉模拟量表、湿疹面积和严重程度指数以及血清生物标志物的评估。视觉模拟量表和湿疹面积和严重程度指数评分显着降低了80%和66.4%,表明奈莫单抗改善了瘙痒和皮肤病变。然而,一些血清AD生物标志物在奈莫单抗治疗期间没有改变。
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