Minimizing the side effects of Doxorubicin Induced Hepatotoxicity by using alcoholic extract of Date Palm in adult rats

Abstract

Doxorubicin (DOX) is a highly effective drug for chemotherapy. However, hepatotoxicity reduces its clinical utility in humans. Thus, this study was designed to examine Date Palm extract on serum anti-inflammatory markers (interleukin(IL) IL-1B, IL-6 and IL-10). Forty adult rats were divided into 4 groups (G1 control, G2 receiving 2mg\kg of DPE orally, G3 treated with 2mg\kg of DOX IP, and G4 received 2mg\kg of DOX via IP and 2mg\kg of DPE by oral gavage daily for 30 days). At the end of the study, animals were sacrificed, and livers were analyzed histologically. The Dox group showed significantly higher levels of serum IL-1B, IL-6, and IL-10 than the control group, with inflammation and necrosis in hepatic histopathology. In the DPE+ DOX group, it was detected that DOX treatment caused a significant decrease in serum IL-1B, IL-6, and IL-10 levels. Collectively, pre-coadministration of DPE partially mitigated DOX-induced hepatic injuries via its antioxidant, anti-inflammatory, anti-fibrotic, and antiapoptotic protein.