Salivary trace elements in patients with ulcerative colitis on different treatment modalities

Q4 Medicine Revista Bionatura Pub Date : 2023-10-15 DOI:10.21931/rb/css/2023.08.04.91
Talib M. Talib, Taghreed Fadhil Zaidan
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引用次数: 1

Abstract

The nutritional status of patients with inflammatory bowel disease is considered less than ideal. This study aimed to compare the salivary levels of some trace elements (Zinc, copper, and magnesium) in patients with ulcerative colitis (UC) on two different therapeutic modalities to control subjects. Materials and methods: This cross-sectional study was performed in 2021-2022 on 53 diagnosed UC patients (27 UC patients on oral immunosuppressant therapy and 26 UC patients on combination therapy). All subjects were randomly selected from gastroenterology and Hepatology teaching hospitals in Baghdad city; twenty-five subjects were also recruited as controls. Demographic data were recorded through a checklist. Salivary levels of zinc (Zn), copper (Cu) and magnesium (Mg) were measured by atomic absorption spectroscopy. Data were analyzed using SPSS-28 at a significance level of 0.05. The results: Salivary Zn mean was significantly lower in monotherapy and combination therapy patients than in controls (p<0.001). Mean salivary Cu levels were significantly higher in monotherapy and combination therapy patients than in controls (p<0.001). Similarly, the salivary Mg mean was significantly lower in both groups of ulcerative colitis patients than in controls (p<0.001). The mean of salivary Cu was higher in UC patients, while the men of Zn and Mg were lower in UC patients compared to controls. Conclusions: The results showed that UC patients have significantly lower Zn and Mg levels than healthy individuals and were lower inpatient on monotherapy than in combination. At the same time, salivary Cu in UC patients was higher than in control individuals and was higher in UC patients on monotherapy. Keywords: Inflammatory bowel diseases, Ulcerative colitis, Trace elements
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不同治疗方式对溃疡性结肠炎患者唾液微量元素的影响
炎症性肠病患者的营养状况被认为不太理想。本研究旨在比较溃疡性结肠炎(UC)患者在两种不同治疗方式下唾液中一些微量元素(锌、铜和镁)的水平。材料与方法:本横断面研究于2021-2022年对53例确诊的UC患者进行研究,其中27例UC患者接受口服免疫抑制剂治疗,26例UC患者接受联合治疗。所有受试者随机选择巴格达市胃肠病学和肝病学教学医院;还招募了25名受试者作为对照。通过核对表记录人口统计数据。用原子吸收光谱法测定唾液中锌(Zn)、铜(Cu)和镁(Mg)的含量。数据采用SPSS-28分析,显著性水平为0.05。结果:单药治疗和联合治疗患者的唾液锌均值显著低于对照组(p<0.001)。单药治疗和联合治疗患者的平均唾液铜水平显著高于对照组(p<0.001)。同样,两组溃疡性结肠炎患者的唾液Mg平均值显著低于对照组(p<0.001)。UC患者唾液中Cu的平均值高于对照组,而Zn和Mg的平均值低于对照组。结论:UC患者的锌、镁水平明显低于健康人群,单药治疗的住院率低于联合治疗。同时,UC患者的唾液含铜量高于对照组,单药治疗的UC患者的唾液含铜量也高于对照组。关键词:炎症性肠病,溃疡性结肠炎,微量元素
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来源期刊
Revista Bionatura
Revista Bionatura Medicine-Epidemiology
CiteScore
0.50
自引率
0.00%
发文量
144
审稿时长
8 weeks
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