Neutralising antibodies against SARS-CoV-2 give important information on Covid-19 epidemic evolution in Rabat, Morocco, March 2020-February 2021

IF 0.8 4区医学 Q3 MEDICINE, GENERAL & INTERNAL African Health Sciences Pub Date : 2023-10-11 DOI:10.4314/ahs.v23i3.46

Nadia Touil, Charifa Drissi Touzani, El Mostafa Benaissa, Jalal Kasouati, Zineb Rhazzar, Hicham El Annaz, Nadia El Mrimar, Lamiae Neffah, Rachid Abi, Rida Tagajdid Rida Tagajdid, Safae El Kochri, Mariette Ducatez, Youssouf Akhouad, Ahmed Reggad, Zouhour El Kassimi, Abdelhamid Zrara, Fatna Bssaibis, ElMostapha El Fahime, Idriss Lahlou Amine, Abdelkader Belmekki, Yashpal Singh Malik, Mostafa Elouennass, Khalid Ennibi

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Abstract

Background: The SARS-CoV-2 is an extremely contagious and acute viral disease mainly affecting humans. Objective: To estimate seroprevalence of SARS-CoV-2 neutralizing antibodies (NAbs) for illegible armed force individuals living in Rabat, Morocco Method: A convenience sample (N = 2662) was conducted from May 2020 to February 2021. We used the standard neutralization assay to quantify the NAbs titers. A serum was positive when the titer was 1:4. High positive NAbs titers were defined when ≥ 1:32. Results: Demographic and socioeconomic status did not affect seroprevalence data. An overall seroprevalence of 24,9% was found. Sera from blood donors, young recruits and auto-immune population had lower NAbs titers. However, titers were above 1:16 in 9% of the population with high risk of SARS-CoV-2 exposure. Seropositivity increased over time with values reaching peaks after the epidemic waves (2.4% in May 2020; 16.2% in August 2020; 22.7% in December 2020 and 37% in February 2021). Conclusion: And increase of NAbs was observed over time and correlated with the post-epidemic waves of COVID-19 in Morocco. Keywords: SARS-CoV-2; Serum neutralizing assay; Seroprevalence; Rabat; Morocco.

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针对SARS-CoV-2的中和抗体提供了2020年3月至2021年2月摩洛哥拉巴特Covid-19流行演变的重要信息

背景:SARS-CoV-2是一种传染性极强的急性病毒性疾病，主要影响人类。目的:了解居住在摩洛哥拉巴特的非辨认武装人员中SARS-CoV-2中和抗体(nab)的血清阳性率;方法:于2020年5月~ 2021年2月抽取方便样本2662例。我们使用标准中和法定量nab滴度。当滴度为1:4时血清呈阳性。高阳性抗体滴度定义为≥1:32。结果:人口统计学和社会经济地位不影响血清阳性率数据。总血清阳性率为24.9%。献血者、年轻新兵和自身免疫人群血清nab滴度较低。然而，在9%的SARS-CoV-2高危人群中，滴度高于1:16。随着时间的推移，血清阳性呈上升趋势，在疫情爆发后达到峰值(2020年5月为2.4%;2020年8月16.2%;2020年12月22.7%，2021年2月37%)。结论:随着时间的推移，nab的升高与摩洛哥COVID-19流行后的浪潮有关。关键词:SARS-CoV-2;血清中和试验;Seroprevalence;拉巴特;摩洛哥。

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来源期刊

African Health Sciences MEDICINE, GENERAL & INTERNAL-

CiteScore

2.30

自引率

0.00%

发文量

179

审稿时长

>12 weeks

期刊介绍： The African Health Sciences is an internationally refereed journal publishing original articles on research, clinical practice, public health, policy, planning, implementation and evaluation, in the health and related sciences relevant to Africa and the tropics. Its objectives are to: Advocate for and promote the growth of reading culture in sub Saharan Africa; Provide a high quality journal in which health and policy and other researchers and practitioners in the region can and world wide, can publish their work; Promote relevant health system research and publication in the region including alternative means of health care financing, the burden of and solution of health problems in marginalized urban and rural communities amongst the displaced and others affected by conflict; Promote research and the systematic collection and collation and publication of data on diseases and conditions of equity and influence; Promote development of evidence-based policies and guidelines for clinical, public health and other practitioners. African Health Sciences acknowledges support provided by the African Health Journals Partnership Project that is funded by the US National Institutes of Health (through the National Library of Medicine and the Fogarty International Center) and facilitated by the Council of Science Editors.