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Clinical nursing application of parenteral nutrition combined with enteral nutrition support in neurosurgery 肠外营养联合肠内营养支持在神经外科中的临床护理应用
4区 医学 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-11-01 DOI: 10.4314/ahs.v23i3.64
Meiying Huang, Sha Yang, Aixia Gu, Mingxia Xu, Cong Sha
Background: To explore the clinical nursing effect of parenteral nutrition combined with enteral nutrition support in neurosurgery. Methodology: 200 neurosurgical patients were randomly divided into two groups. The time of parenteral nutrition combined with enteral nutrition support in our hospital (January 2021) was used as the cut-off point, the PN group and the PN+EN group were divided according to the cut-off point. Nutritional status, immune status, occurrence of adverse events, prognosis-related indicators were compared between the two groups. Results: Nutritional status and immune status at 7 days of nutritional support in the PN+EN group were higher than those in the PN group, The difference was statistically significant. The total incidence of adverse events in the PN+EN group (3.00%) was significantly lower than that in the PN group (11.00%), and the difference was statistically significant. The average ICU treatment time, average hospital stay and emerging infection rate in the PN+EN group were lower than those in the PN group, and the differences were statistically significant (P < 0.05). Conclusion: Parenteral nutrition combined with enteral nutrition support in neurosurgery can achieve a more ideal intervention effect. It is beneficial to the prognosis of patients and has a certain value of promotion and application. Keywords: Neurosurgery; parenteral nutrition support; enteral nutrition support; nursing effect.
目的:探讨肠外营养联合肠内营养支持在神经外科中的临床护理效果。 方法:将200例神经外科患者随机分为两组。以我院肠外营养联合肠内营养支持时间(2021年1月)为分界点,按分界点分为PN组和PN+EN组。比较两组患者的营养状况、免疫状况、不良事件发生情况及预后相关指标。 结果:营养支持7 d时PN+EN组的营养状况和免疫状况均高于PN组,差异有统计学意义。PN+EN组总不良事件发生率(3.00%)显著低于PN组(11.00%),差异有统计学意义。PN+EN组的平均ICU治疗时间、平均住院时间、新发感染率均低于PN组,差异有统计学意义(P <0.05)强生# x0D;结论:在神经外科手术中,肠外营养联合肠内营养支持可取得更理想的干预效果。有利于患者的预后,具有一定的推广应用价值。 关键词:神经外科;肠外营养支持;肠内营养支持;护理效果。
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引用次数: 0
Editorial: Reducing the risks of nuclear war: the role of health professionals 社论:降低核战争风险:卫生专业人员的作用
IF 1 4区 医学 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-10-11 DOI: 10.4314/ahs.v23i3.2
K. Abbasi, P. Ali, V. Barbour, K. Bibbins-Domingo, Marcel G M Olde Rikkert, P. Gong, Andy Haines, Ira Helfand, R. Horton, Bob Mash, A. Mitra, C. Monteiro, Elena N Naumova, Eric J Rubin, Tilman Ruff, P. Sahni, J. Tumwine, P. Yonga, Chris Zielinski
NIL
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引用次数: 0
Efficacy of arthroscopic internal fixation with countersunk screw in the treatment of talus fracture 关节镜下埋头螺钉内固定治疗距骨骨折的疗效观察
4区 医学 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-10-11 DOI: 10.4314/ahs.v23i3.61
Bo Sun, Shibo Liu, Xinxin Xue, Yunfeng Gao, Shijie Fu, Pei Wang
Objective: To explore clinical effects of arthroscopic internal fixation with countersunk screw in the treatment of talus fracture. Methods: Forty-eight patients with talus fracture treated in hospital of Chengde Medical University from February 2015 to December 2019 were enrolled for present investigation. The patients with talus fracture were randomly assigned into two groups, with twenty-four patients per group. The patients with talus fracture in the observation group were treated with arthroscopic internal fixation with countersunk screw, while the traditional open reduction and internal fixation were applied for the ones in control group. The clinical efficacy of the patients was evaluated three months after the operation, and the preoperative and postoperative ankle joint functions, fracture-healing time, hospital stay, and complications were carefully compared between observation and control group. Results: A total efficiency as high as 91.67% was showed in observation group, which is distinctly better than the effective rate of control group (66.67%, P<0.05). Before operation, ankle function scores (AOFAS) of control group and observation group is 42.08 ± 4.29 and 41.75±5.31 with no significantly difference (P>0.05); while after the surgery, AOFAS scores of control group is significantly lower than that of observation group: (66.28±7.51 vs. 53.0 ±6.79, P<0.05). Moreover, healing time and hospitalized duration of observation group are 3.19±1.04 months and 3.57±0.97 days, which are also significantly shorter than 4.18±1.25 months and 8.28±2.54 days in control group, respectively, (P < 0.05). And the total complication rate in control group is 20.83%, which is higher than 8.33% in observation group (P >0.05). Conclusion: Arthroscopic internal fixation with countersunk screw can significantly improve the efficacy and ankle joint functions, shorten the fracture-healing time and hospital stays without increasing the incidence of complications. Keywords: Arthroscopy; countersunk screw; curative effect; internal fixation; talar fracture.
目的:探讨关节镜下沉头螺钉内固定治疗距骨骨折的临床疗效。方法:选取2015年2月至2019年12月承德医科大学附属医院收治的距骨骨折患者48例为研究对象。距骨骨折患者随机分为两组,每组24例。观察组距骨骨折采用关节镜下沉头螺钉内固定治疗,对照组采用传统切开复位内固定治疗。术后3个月评估患者的临床疗效,并仔细比较观察组与对照组术前、术后踝关节功能、骨折愈合时间、住院时间及并发症。 结果:观察组总有效率高达91.67%,明显优于对照组66.67% (p < 0.05)。术前,对照组与观察组患者踝关节功能评分(AOFAS)分别为42.08±4.29、41.75±5.31,差异无统计学意义(P>0.05);术后,对照组AOFAS评分显著低于观察组:(66.28±7.51∶53.0±6.79,p < 0.05)。观察组患者愈合时间为3.19±1.04个月,住院时间为3.57±0.97天,也显著短于对照组的4.18±1.25个月和8.28±2.54天(P <0.05)。对照组总并发症发生率20.83%,高于观察组8.33% (P >0.05)。 结论:关节镜下沉头螺钉内固定能明显改善疗效和踝关节功能,缩短骨折愈合时间和住院时间,且不增加并发症的发生率。 关键词:关节镜;沉头螺钉;疗效;内固定;talar骨折。
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引用次数: 0
Evaluation of socio-demographic profile and basic risk factors of tuberculosis patients in South 24 Parganas district of West Bengal, India: a hospital-based study 印度西孟加拉邦南24帕尔加纳斯区结核病患者的社会人口特征和基本危险因素评估:一项基于医院的研究
4区 医学 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-10-11 DOI: 10.4314/ahs.v23i3.42
Sujay Kumar Bhunia, Sananda Dey, Amitava Pal, Biplab Giri
Aim: To study and analyse the socio-demographic profile and basic risk factors of tuberculosis(TB) patients and their relationwith the current epidemiological status of TB registered under the RNTEP program in the study area. Subjects and Methods: This prospective study was conducted on 1743 newly registered tuberculosis patients at TB-DOT centerof South 24 Parganas, West Bengal, India from 2011-2014. Socio-demographic variables and baseline characteristics of theparticipants were noted by a semi-structured questionnaire. Results: Our study results indicate that more than 95% of the TB patients were from lower socioeconomic class, and hadpoor literacy status and tuberculosis was observed highest in non-agricultural labour and cultivators. Among the young adult’smajority of the affected population were females from the lower/upper-lower socioeconomic class. Our analysis revealed that,in successful tuberculosis therapy, men were more defaulters than women. Conclusion: Our study provides a socioeconomic profile and the risk factors of tuberculosis in patients such as the status oftherapeutic intervention, involvement of other chronic diseases, age, sex and malnutrition. The findings of this study can beused to plan future studies with specific risk factors of the region and also for implementing the intervention and evaluating itseffectiveness.Keywords: Mycobacterium tuberculosis; socio-demographic factors; multi-drug resistance; pulmonary tuberculosis; extra-pulmonarytuberculosis.
目的:研究分析研究区RNTEP项目登记结核病患者的社会人口学特征、基本危险因素及其与结核病流行病学现状的关系。对象与方法:本前瞻性研究对2011-2014年在印度西孟加拉邦南24 Parganas结核病- dot中心新登记的1743例结核病患者进行了研究。通过半结构化问卷记录了参与者的社会人口变量和基线特征。 结果:95%以上的结核病患者来自社会经济较低阶层,文化水平较低,非农业劳动力和耕耘者结核病发病率最高。在年轻人中,大多数受影响的人群是来自较低/上层社会经济阶层的女性。我们的分析显示,在成功的结核病治疗中,男性的违约率高于女性。结论:我们的研究提供了结核病患者的社会经济概况和危险因素,如治疗干预状况、其他慢性疾病的参与、年龄、性别和营养不良。本研究的结果可用于规划该地区特定风险因素的未来研究,也可用于实施干预和评估其有效性。关键词:结核分枝杆菌;socio-demographic因素;耐多药;肺结核;extra-pulmonarytuberculosis。
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引用次数: 0
Assessment of risk factors associated with multi-drug resistant tuberculosis (MDR-TB) in Gulu regional referral hospital 鼓鲁地区转诊医院耐多药结核病相关危险因素评估
4区 医学 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-10-11 DOI: 10.4314/ahs.v23i3.41
Kizito Omona, Albert Mucha Opiyo
Background: Multi-drug resistant tuberculosis (MDR-TB) is increasingly recognized as emerging infectious disease of publichealth concern. Globally, 206030 people were diagnosed with MDR-TB in 2019, representing a 10% increase from 186883peoplewho had it in 2018. In Uganda, the prevalence of MDR among new TB cases is 4.4% and 17.7% among previously treatedTB cases. Aim: To determine the risk factors associated with MDR-TB among tuberculosis patients in Gulu regional referral hospital. Material and Methods: A cross-sectional analytical study using both quantitative and qualitative methods of data collectionand analysis was used. Data was collected from 384 TB patients using data extraction form and 6 Key informant interviewsconducted. Analysis using Pearson chi-square test was run. Results: HIV positive patients were 2.6 times more likely to be infected with MDR-TB than HIV negative patients [AOR=2.6:95% CI 1.34– 5.85: P=0.006]. Previously treated TB patients were 2.8 times more likely to be infected with MDR-TB than newlydiagnosed TB patients [AOR=2.8: 95% CI 1.33– 5.85: P=0.006]. Defaulting TB patients were 3.1 times more likely to be infectedwith MDR-TB than the non-defaulting TB patients [AOR=3.1] Conclusion: There is high prevalence of drug resistance among patients attending TB treatment at the facility. Keywords: MDR-TB; tuberculosis; HIV; Gulu Regional Referral Hospital.
背景:耐多药结核病(MDR-TB)日益被认为是引起公共卫生关注的新兴传染病。2019年,全球有206030人被诊断患有耐多药结核病,比2018年的186883人增加了10%。在乌干达,耐多药耐药在新发结核病例中的流行率为4.4%,在以前治疗过的结核病例中为17.7%。目的:了解鼓鲁地区转诊医院结核病患者耐多药结核病相关危险因素。材料和方法:采用横断面分析研究,采用定量和定性的数据收集和分析方法。采用数据抽取法对384例结核病患者进行数据收集,并对6名关键信息提供者进行访谈。采用Pearson卡方检验进行分析。 结果:HIV阳性患者感染耐多药结核病的可能性是HIV阴性患者的2.6倍[AOR=2.6:95% CI 1.34 ~ 5.85: P=0.006]。既往结核病患者感染耐多药结核病的可能性是新诊断结核病患者的2.8倍[AOR=2.8: 95% CI 1.33 - 5.85: P=0.006]。默认结核患者感染耐多药结核的可能性是非默认结核患者的3.1倍[AOR=3.1] 结论:该院结核病患者耐药率较高。 关键词:耐多药结核病;肺结核;艾滋病毒;古鲁地区转诊医院。
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引用次数: 0
Correlation between protein expression profiling of inflammation and bone metabolism in rheumatoid arthritis patients 类风湿关节炎患者炎症蛋白表达谱与骨代谢的相关性
4区 医学 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-10-11 DOI: 10.4314/ahs.v23i3.73
Jie Wang, Jian Liu
Objective: In patients with rheumatoid arthritis (RA), osteoarthrosis significantly reduces self-perception. However, the intrinsicrelationship between bone metabolism and SPP and cell activity at the molecular level remains unclear. The purpose of thisstudy was to understand the relationship between RA bone metabolic indicators and immune inflammation-related proteins. Methods: A total of 30 patients with RA and 30 healthy controls were recruited. Four bone metabolism measures and nineproteins expression measures were collected from RA patients and healthy controls. Spearman Correlation Analysis and Logistic-regression Analysis were adopted for associations between bone metabolism and proteins. Results: We screened and verified 3 key proteins, namely interleukin-11 (IL-11), interleukin-17 (IL-17) and programmed celldeath-2 (PD-L2) related to immunity and inflammation through microarray analysis. Levels of IL-2, IL-5, IL-11, IL-17, CTLA4,TNF-β were higher in RA patients than in the control group (P<0.05), meanwhile, the levels of IL-8, PD-L2, TNF-β and B7-2were low in RA patients (P>0.05).The results of Spearman Correlation Test suggested that sharp score was positively correlatedwith age, CCP was positively correlated with RF, SDS score was positively correlated with RF, IL-17 was positively correlatedwith CCP, BGP was positively correlated with BALP, RANKL was positively correlated with BALP, VAS score was negativelycorrelated with CRP, TCM score was negatively correlated with SF-36 score. Conclusion: BALP, BGP, OPG, RANKL were strongly associated with immune inflammation-related proteins and poor SPPin RA patients, which can be used to predict poor SPP in RA patients, although the underlying mechanisms need to be furtherexplored.Keywords: Rheumatoid arthritis; bone destruction; self-perception of patient; protein expression profiling.
目的:在类风湿关节炎(RA)患者中,骨关节病显著降低自我知觉。然而,骨代谢与SPP和细胞活性在分子水平上的内在关系尚不清楚。本研究的目的是了解RA骨代谢指标与免疫炎症相关蛋白的关系。 方法:共招募30例RA患者和30例健康对照者。收集RA患者和健康对照者的4项骨代谢指标和9项蛋白表达指标。骨代谢与蛋白质的相关性采用Spearman相关分析和logistic回归分析。 结果:通过芯片分析筛选并验证了与免疫和炎症相关的3个关键蛋白,即白细胞介素-11 (IL-11)、白细胞介素-17 (IL-17)和程序性细胞死亡-2 (PD-L2)。RA患者IL-2、IL-5、IL-11、IL-17、CTLA4、TNF-β水平高于对照组(P>0.05), IL-8、PD-L2、TNF-β、b7 -2水平低于对照组(P>0.05)。Spearman相关检验结果显示,sharp评分与年龄正相关,CCP与RF正相关,SDS评分与RF正相关,IL-17与CCP正相关,BGP与BALP正相关,RANKL与BALP正相关,VAS评分与CRP负相关,中医评分与SF-36评分负相关。 结论:BALP、BGP、OPG、RANKL与免疫炎症相关蛋白及SPPin不良RA患者相关性强,可用于预测RA患者SPP不良,但其机制有待进一步探讨。关键词:类风湿性关节炎;骨质破坏;患者自我知觉;蛋白表达谱。
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引用次数: 0
Neonatal factors associated with immediate low Apgar score in newborn babies in an intermediate hospital in Namibia: a case control study 纳米比亚一家中级医院新生儿中与即时低阿普加评分相关的新生儿因素:一项病例对照研究
4区 医学 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-10-11 DOI: 10.4314/ahs.v23i3.18
Justina Lungameni, Emma Maano Nghitanwa, Laura Uusiku
Introduction: Apgar score is conducted to a baby immediately after birth checking how the baby tolerated the birth processand outside the uterus. Objectives: To describe the neonatal factors associated with immediate low Apgar score and analysing the associations amongfactors associated with low Apgar score in new-born babies. Methods: A quantitative, case-control, descriptive research design was used. Study population were all maternal records ofdeliveries conducted between 01 January 2019 and 31 December 2019. Simple random sampling was used to select the samplesize for 194 cases and 194 controls using a 1:1 case-control ratio. Records indicating low Apgar scores were the cases while normalApgar scores were the controls. A total of 388 maternal files were reviewed. Data were collected using a document reviewchecklist and analysed using SPSS version 26. Results: The study found that, neonatal factors associated with immediate low Apgar score are; gestational age, foetal presentation,cord prolapse, cord around the neck and the importance of cardiotocography interpretation as they had a P-value > 0.005. Conclusion: Gestational age, birth weight, foetal presentation, cord around the neck and lack of cardiotocography assessmentwere found to be associated with immediate low Apgar score. Keywords: Neonatal; factors; immediate low Apgar score; newborn; babies.
介绍:Apgar评分是在婴儿出生后立即进行的,检查婴儿对分娩过程和子宫外的耐受情况。目的:描述新生儿即时低Apgar评分的相关因素,并分析新生儿低Apgar评分相关因素之间的相关性。 方法:采用定量、病例对照、描述性研究设计。研究人群为2019年1月1日至2019年12月31日期间分娩的所有产妇记录。采用简单随机抽样的方法选取194例病例和194例对照,按1:1的病例-对照比进行抽样。记录显示低Apgar评分为病例,而正常Apgar评分为对照。共审查了388份产妇档案。采用文献回顾表收集数据,并使用SPSS version 26进行分析。 结果:本研究发现,与新生儿即刻低Apgar评分相关的因素有;胎龄,胎儿表现,脐带脱垂,脐带绕颈和心脏造影解释的重要性,因为它们有p值>0.005 # x0D公司;结论:胎龄、出生体重、胎儿体位、脐带绕颈和缺乏心脏造影评估与即刻低Apgar评分有关。 关键词:新生儿;因素;即时低Apgar评分;新生儿;婴儿。
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引用次数: 0
Quality of life of patients with traumatic spinal cord injuries: a cross-sectional study at a tertiary hospital in Uganda 创伤性脊髓损伤患者的生活质量:乌干达一家三级医院的横断面研究
4区 医学 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-10-11 DOI: 10.4314/ahs.v23i3.60
Rogers Mugisa, Edward Luke Kironde, Erisa Sabakaki Mwaka
Background: The study aimed to assess the perceived quality of life of patients with traumatic spinal cord injuries. Methodology: This was a cross sectional study conducted in the Spine Unit of a tertiary hospital in Uganda. The study population comprised of patients with spinal cord injuries. Data were collected using the WHO Quality of Life Brief questionnaire and Functional Independence Measure tool. Results: 103 patients participated in the study, most were male (73.8%), and had a mean age of 37.7 years. Most participants were married (57.3%), unemployed (72.8%) and had no steady source of income (62.1%). Road traffic accidents accounted for most injuries (59.2%). The mean duration since injury was 20.5 months. Most participants (58.3%) had incomplete spinal cord injuries and 84.5% had complications. The perceived overall quality of life was poor in 87.4% of patients. Being employed (p= 0.02), the presence of complications (p= 0.03), and injury severity (p= 0.003) significantly affected quality of life. Functional independent measure scores were significantly better in individuals less severe injuries and those with lumbar level of injury with mean scores of 113.1±8.9 and 99.9±15.3 respectively. Conclusion: The overall self-reported quality of life among patients with traumatic spinal cord injury was generally poor. Keywords: Quality of life; traumatic injury; spinal cord.
背景:本研究旨在评估外伤性脊髓损伤患者的感知生活质量。 方法:这是一项横断面研究在乌干达三级医院脊柱部进行。研究人群包括脊髓损伤患者。使用WHO生活质量问卷和功能独立性测量工具收集数据。 结果:103例患者参与研究,男性居多(73.8%),平均年龄37.7岁。大多数参与者已婚(57.3%)、失业(72.8%)和没有稳定收入来源(62.1%)。道路交通事故伤害最多(59.2%)。平均受伤时间为20.5个月。大多数参与者(58.3%)有不完全性脊髓损伤,84.5%有并发症。87.4%的患者感觉总体生活质量较差。受雇(p= 0.02)、并发症(p= 0.03)和损伤严重程度(p= 0.003)显著影响生活质量。功能独立测量评分在轻度损伤个体和腰椎水平损伤个体中均显著提高,平均评分分别为113.1±8.9和99.9±15.3。 结论:外伤性脊髓损伤患者总体自我报告生活质量普遍较差。 关键词:生活质量;创伤性损伤;脊髓。
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引用次数: 0
Prevalence and factors associated with low birth weight among newborns in South Sudan 南苏丹新生儿低出生体重的患病率及相关因素
4区 医学 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-10-11 DOI: 10.4314/ahs.v23i3.19
Chol Lat, Florence Murila, Dalton Wamalwa
Background: WHO estimates that that 13% of babies are delivered low birth weight in Sub-Saharan Africa. Infants with LBWhave a twenty times greater risk of dying than infants weighing more than 2500 grams. The neonatal mortality rates in SouthSudan is 40 per 1000 live births. LBW significantly contributes to neonatal mortality rates. Objectives: The study aimed at determining the prevalence and factors associated with LBW among newborns. Methods: This was a cross-sectional descriptive study conducted at three hospitals. Completed data on all live births was collectedusing a structured questionnaire. Univariate and multivariate logistic regression analysis was applied for factors associated withLBW. Adjusted odds ratio with 95% confidence interval was applied and a P value < 0.05 was considered statistically significant. Results: We retrieved records of 11845 birth cohorts. The prevalence of LBW among newborns was 11.4%. The prevalenceof LBW at Aweil, Juba and Bor was 13.3%, 9.8% and 8.8% respectively. Maternal age less than 20 years and 35 years and above,multigravidity, GA < 37 weeks, male sex and multiple pregnancy were significantly associated with LBW. Conclusion: The prevalence of LBW in infants was 11.4%. Associated factors were, maternal age, GA < 37 weeks, multigravidity,male sex and multiple pregnancy. Keywords: Low birth weight; improve birth outcomes; multivariate logistic regression analysis.
背景:世卫组织估计,在撒哈拉以南非洲,13%的婴儿出生时体重过低。与体重超过2500克的婴儿相比,低体重婴儿的死亡风险要高20倍。南苏丹的新生儿死亡率为每1000例活产死亡40例。低体重对新生儿死亡率有显著影响。 目的:本研究旨在确定新生儿LBW的患病率及其相关因素。方法:在三家医院进行横断面描述性研究。使用结构化问卷收集所有活产婴儿的完整数据。对影响体重的因素进行单因素和多因素logistic回归分析。采用95%置信区间的校正优势比,P值<0.05认为有统计学意义。 结果:我们检索了11845个出生队列的记录。新生儿LBW患病率为11.4%。Aweil、Juba和Bor的LBW患病率分别为13.3%、9.8%和8.8%。产妇年龄小于20岁,35岁及以上,多胎,GA <37周时,男性和多胎妊娠与LBW显著相关。 结论:婴幼儿LBW患病率为11.4%。相关因素为:产妇年龄、GA和lt;37周,多胎,男性和多胎妊娠。 关键词:低出生体重;改善生育结果;多因素logistic回归分析。
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引用次数: 0
Postpartum resolution of hypertension, proteinuria and acute kidney injury among women with preeclampsia and severe features at Mulago National Referral Hospital, Uganda: a cohort study 在乌干达穆拉戈国家转诊医院,患有子痫前期和严重症状的妇女中高血压、蛋白尿和急性肾损伤的产后缓解:一项队列研究
4区 医学 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-10-11 DOI: 10.4314/ahs.v23i3.6
Kasereka Muteke, Milton W Musaba, David Mukunya, Jolly Beyeza, Julius N Wandabwa, Paul Kiondo
Background: The resolution of hypertension, proteinuria and AKI postpartum among women with preeclampsia is not well documented in Uganda. Objective: To determine the time to resolution of hypertension, proteinuria and AKI postpartum until 6 weeks among women with preeclampsia in Mulago Hospital, Uganda. Methods: Between August 2017 and April 2018, we measured blood pressure, urine protein and serum creatinine on days 1,7,21 and 42 postpartum among 86 women with preeclampsia. The primary outcomes were time to the resolution of hypertension, proteinuria and AKI. We fitted accelerated failure models using Stata 17’s stintreg. command with a log normal distribution and obtained time ratios of selected exposures on time to resolution of hypertension, proteinuria and AKI intervals. Results: The median time to resolution of hypertension, proteinuria and AKI was seven (7) days (Inter quartile range, IQR 1-21). The time to resolution of hypertension among primiparous women was 3.5 times that of multiparous women [TR 3.5, 95%CI 1.1, 11.3]. No differences were observed in resolution of hypertension, proteinuria and acute kidney injury. Conclusion: The time to resolution of hypertension, proteinuria and AKI was seven days. We recommend larger studies with longer follow-up beyond six-weeks postpartum to inform revision of our guidelines. Keywords: Acute kidney injury; preeclampsia with severe features.
背景:在乌干达,子痫前期妇女产后高血压、蛋白尿和AKI的解决尚未得到很好的记录。 目的:了解乌干达穆拉戈医院子痫前期妇女产后6周高血压、蛋白尿和AKI的消退时间。 方法:在2017年8月至2018年4月期间,我们测量了86例子痫前期妇女产后1、7、21和42天的血压、尿蛋白和血清肌酐。主要终点是高血压、蛋白尿和AKI消退的时间。我们使用Stata 17的字符串拟合加速失效模型。命令,符合对数正态分布,并获得选定暴露时间与高血压、蛋白尿和AKI时间间隔的时间比。 结果:高血压、蛋白尿和AKI缓解的中位时间为7天(四分位数间距,IQR 1-21)。初产妇女高血压消退的时间是多产妇女的3.5倍[TR 3.5, 95%CI 1.1, 11.3]。在高血压、蛋白尿和急性肾损伤的消退方面,两组无差异。 结论:高血压、蛋白尿和AKI的消退时间为7天。我们建议进行更大规模的研究,随访时间超过产后6周,以便为我们指南的修订提供信息。关键词:急性肾损伤;伴有严重症状的先兆子痫。
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引用次数: 0
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African Health Sciences
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