Values of serum neutrophil gelatinase-associated lipocalin and cystatin C after percutaneous coronary intervention for early diagnosis of contrast-induced nephropathy

IF 0.8 4区医学 Q3 MEDICINE, GENERAL & INTERNAL African Health Sciences Pub Date : 2023-10-11 DOI:10.4314/ahs.v23i3.69

Ping Luo, Wei Ao, Dikai Xiang, Jian Wang, Jia Liu

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Abstract

Objective: Serum creatinine (SCr) is not a sensitive and reliable index for the early diagnosis of acute kidney injury caused bycontrast-induced nephropathy (CIN). The aim of this study was to explore the values of serum neutrophil gelatinase-associatedlipocalin (NGAL) and cystatin C (Cys-C) after percutaneous coronary intervention (PCI) for the early diagnosis of CIN. Methods: Three hundred patients receiving PCI from January 2018 to December 2020 were assigned to a CIN group (n=25)and a non-CIN group (n=275), respectively. SCr, Cys-C and NGAL levels were measured, and their sensitivities for early CINdiagnosis were evaluated by the area under the receiver operating characteristic curve (AUC) values. Results: The NGAL and Cys-C levels of the CIN group began to rise 6 and 12 h after operation, respectively (P<0.05). TheCIN group had higher NGAL and Cys-C levels than those of the non-CIN group 12, 24 and 48 h after operation (P<0.05). TheAUC values of NGAL, Cys-C and SCr 24 h after operation were 0.885, 0.874 and 0.856, respectively. Conclusion: The serum NGAL and Cys-C levels of patients after PCI reflect the early changes of renal function, which arevaluable for early CIN diagnosis. Keywords: Contrast; cystatin C; nephropathy; neutrophil gelatinase-associated lipocalin; percutaneous coronary intervention.

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经皮冠状动脉介入治疗后血清中性粒细胞明胶酶相关脂钙素和胱抑素C对造影剂肾病早期诊断的价值

目的:血清肌酐(SCr)是早期诊断造影剂肾病(CIN)急性肾损伤的一个不敏感、不可靠的指标。本研究的目的是探讨经皮冠状动脉介入治疗(PCI)后血清中性粒细胞明胶酶相关脂钙素(NGAL)和胱抑素C (cysc)在早期诊断CIN中的价值。方法:2018年1月至2020年12月接受PCI治疗的患者300例，分别分为CIN组(n=25)和非CIN组(n=275)。测定SCr、Cys-C和NGAL水平，并通过受试者工作特征曲线下面积(AUC)值评价其对早期cind诊断的敏感性。结果:CIN组NGAL和Cys-C水平分别在术后6 h和12 h开始升高(p < 0.05)。术后12、24、48 h, cin组NGAL、Cys-C水平高于非cin组(p < 0.05)。术后24 h NGAL、Cys-C、SCr的auc值分别为0.885、0.874、0.856。结论:PCI术后患者血清NGAL、Cys-C水平反映早期肾功能变化，对CIN早期诊断有价值。关键词:对比;半胱氨酸蛋白酶抑制物C;肾病;中性粒细胞明胶酶相关脂钙蛋白;经皮冠状动脉介入治疗。

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来源期刊

African Health Sciences MEDICINE, GENERAL & INTERNAL-

CiteScore

2.30

自引率

0.00%

发文量

179

审稿时长

>12 weeks

期刊介绍： The African Health Sciences is an internationally refereed journal publishing original articles on research, clinical practice, public health, policy, planning, implementation and evaluation, in the health and related sciences relevant to Africa and the tropics. Its objectives are to: Advocate for and promote the growth of reading culture in sub Saharan Africa; Provide a high quality journal in which health and policy and other researchers and practitioners in the region can and world wide, can publish their work; Promote relevant health system research and publication in the region including alternative means of health care financing, the burden of and solution of health problems in marginalized urban and rural communities amongst the displaced and others affected by conflict; Promote research and the systematic collection and collation and publication of data on diseases and conditions of equity and influence; Promote development of evidence-based policies and guidelines for clinical, public health and other practitioners. African Health Sciences acknowledges support provided by the African Health Journals Partnership Project that is funded by the US National Institutes of Health (through the National Library of Medicine and the Fogarty International Center) and facilitated by the Council of Science Editors.