Evaluation of spin labeled TEPA and CCNU analogs against osteosarcoma and MNU-induced mammary carcinoma of the SD-rat.

Archiv fur Geschwulstforschung Pub Date : 1989-01-01
T Klenner, M R Berger, G Sosnovsky, N U Rao, F Wingen, D Schmähl
{"title":"Evaluation of spin labeled TEPA and CCNU analogs against osteosarcoma and MNU-induced mammary carcinoma of the SD-rat.","authors":"T Klenner,&nbsp;M R Berger,&nbsp;G Sosnovsky,&nbsp;N U Rao,&nbsp;F Wingen,&nbsp;D Schmähl","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The effectiveness to reduce tumor growth by 1-(2-chloroethyl)-3-(1-oxyl-2,2,6,6-tetramethylpiperidinyl)- 1-nitrosourea (SLCNU) and N,N,N,'N'- bis(1,2-ethanediyl)-N\"-(1-oxyl-2,2,6,6-tetramethyl- 2-piperidinylaminocarbonyl)-phosphoric triamide (SLDU) was studied in osteosarcoma and MNU-induced mammary carcinoma in the SD-rat. Both compounds elicited neither an inhibitory effect on these tumors nor an increase in the mean/median life span as compared to the control group.</p>","PeriodicalId":8274,"journal":{"name":"Archiv fur Geschwulstforschung","volume":"59 4","pages":"251-6"},"PeriodicalIF":0.0000,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Archiv fur Geschwulstforschung","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

The effectiveness to reduce tumor growth by 1-(2-chloroethyl)-3-(1-oxyl-2,2,6,6-tetramethylpiperidinyl)- 1-nitrosourea (SLCNU) and N,N,N,'N'- bis(1,2-ethanediyl)-N"-(1-oxyl-2,2,6,6-tetramethyl- 2-piperidinylaminocarbonyl)-phosphoric triamide (SLDU) was studied in osteosarcoma and MNU-induced mammary carcinoma in the SD-rat. Both compounds elicited neither an inhibitory effect on these tumors nor an increase in the mean/median life span as compared to the control group.

分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
自旋标记TEPA和CCNU类似物对sd大鼠骨肉瘤和mnu诱导的乳腺癌的作用。
研究了1-(2-氯乙基)-3-(1-氧基-2,2,6,6-四甲基哌替啶基)- 1-亚硝基脲(SLCNU)和N,N,N,'N'-双(1,2-乙二基)-N"-(1-氧基-2,2,6,6-四甲基-2 -哌替啶基氨基羰基)-磷酸三酰胺(SLDU)对sd大鼠骨肉瘤和mnu诱导的乳腺癌的抑制作用。与对照组相比,这两种化合物既没有对这些肿瘤产生抑制作用,也没有增加平均/中位寿命。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
T-cell lymphomas. Methodological aspects on cytochemical DNA assessment of adenocarcinoma of the endometrium by means of image and flow cytometry using conventionally formalin-fixed and paraffin-embedded specimens. [The fundamental problems and evaluation criteria for rational imaging diagnosis in oncology]. Experimental metastasis inhibition by pretreatment of the host. Inducible expression of the proto-oncogene c-fos in transgenic mice.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1