Association between YKL-40 and Cardiovascular Events in Hemodialysis Patients

Enas Ahmad, Howyda Shabaan, Doaa Amin, Dina Abdelmotaleb
{"title":"Association between YKL-40 and Cardiovascular Events in Hemodialysis Patients","authors":"Enas Ahmad, Howyda Shabaan, Doaa Amin, Dina Abdelmotaleb","doi":"10.21608/bmfj.2023.237606.1905","DOIUrl":null,"url":null,"abstract":": Background: YKL-40, a glycoprotein, is associated with inflammatory conditions, including endothelial dysfunction and atherosclerosis. This study aimed to assess the significance of YKL-40 levels in the serum in a hemodialysis (HD) population and investigate their connection to cardiovascular disease (CVD) development. Methods: A case-control study was conducted from August 2022 to January 2023, involving 80 participants (30 patients with CVD and chronic HD, 30 patients with chronic HD without CVD, and 20 apparently healthy individuals). Laboratory assessments encompassed kidney function tests (creatinine and urea), serum sodium and potassium levels, Troponin I, highly sensitive C-reactive protein (Hs-CRP), and serum YKL-40 concentrations measured using ELISA. Incidences of CVD events among the patients were documented. Results: Significantly elevated YKL-40 levels were observed in HD patients with CVD compared to HD patients without CVD and the control group (p<0.001). There was also a significant increase in YKL-40 in HD patients without CVD compared to the control group (p<0.001). Additionally, a significant positive correlation was found between YKL-40 and Troponin I (p<0.001) in HD patients, both with and without CVD. ROC analysis indicated that YKL-40, with a cutoff value of >928.4 ng/ml, could effectively differentiate between HD patients with and without CVD. Both univariate and multivariate analyses demonstrated that troponin I and YKL-40 were associated with an increased likelihood of CVD among HD patients. Conclusion: YKL-40 is a biomarker associated with inflammation, and it is shown to have elevated levels among patients with HD. Among those patients, our study shows that YKL-40","PeriodicalId":8803,"journal":{"name":"Benha Veterinary Medical Journal","volume":"14 8","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Benha Veterinary Medical Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.21608/bmfj.2023.237606.1905","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

: Background: YKL-40, a glycoprotein, is associated with inflammatory conditions, including endothelial dysfunction and atherosclerosis. This study aimed to assess the significance of YKL-40 levels in the serum in a hemodialysis (HD) population and investigate their connection to cardiovascular disease (CVD) development. Methods: A case-control study was conducted from August 2022 to January 2023, involving 80 participants (30 patients with CVD and chronic HD, 30 patients with chronic HD without CVD, and 20 apparently healthy individuals). Laboratory assessments encompassed kidney function tests (creatinine and urea), serum sodium and potassium levels, Troponin I, highly sensitive C-reactive protein (Hs-CRP), and serum YKL-40 concentrations measured using ELISA. Incidences of CVD events among the patients were documented. Results: Significantly elevated YKL-40 levels were observed in HD patients with CVD compared to HD patients without CVD and the control group (p<0.001). There was also a significant increase in YKL-40 in HD patients without CVD compared to the control group (p<0.001). Additionally, a significant positive correlation was found between YKL-40 and Troponin I (p<0.001) in HD patients, both with and without CVD. ROC analysis indicated that YKL-40, with a cutoff value of >928.4 ng/ml, could effectively differentiate between HD patients with and without CVD. Both univariate and multivariate analyses demonstrated that troponin I and YKL-40 were associated with an increased likelihood of CVD among HD patients. Conclusion: YKL-40 is a biomarker associated with inflammation, and it is shown to have elevated levels among patients with HD. Among those patients, our study shows that YKL-40
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
血液透析患者YKL-40与心血管事件的关系
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Cowpea 11S globulin spray quadruples shrimp shelf-life and maintains freshness Prevalence of some Foodborne Pathogens (FBPs) in imported chilled and frozen beef in Egypt Evaluation of the antidiabetic and hepatoprotective effect of Origanum majorana leaf extract and its nanoparticles in streptozotocin-induced diabetes in rats Ameliorative effect of lemon balm on eltroxin induced-hyperthyroidism in rats Molecular characterization of isolated duck viral hepatitis and its pathogenicity in one day and seven day old ducklings in Qalyubia governorate.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1