The Role of Metallic Nanoparticles in the Prevention and Treatment of Parasitic Diseases in Poultry

Fatemeh Heshmati, Shimen Gevargiz Sangar, Amirmehdi Amoozadehsamakoosh, Elham Azadi, Nima Komeili
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Abstract

The development of nanotechnology for the treatment of parasitic diseases is still in its infancy. However, it is expected that this new field can provide a solution to parasitic diseases and compensate for the lack of vaccines to prevent them. It can also provide new treatment options for parasitic diseases resistant to current treatments. Nanomaterials have been developed for antibacterial and anticancer therapies. However, it is important to determine their antiparasitic potential due to the wide variety of their physicochemical properties. When designing metallic nanoparticles (MeNPs) and specialized nanosystems like MeNPs encapsulated within a drug shell, it is essential to consider several key physicochemical properties. Shape, size, surface charge, and type of surfactant control are some of these physicochemical properties. In addition to interacting with parasite cells’ target molecules, shell molecules are also important. By developing antiparasitic drugs using nanotechnology and nanomaterials for diagnostics, new and effective methods of treatment and diagnostic tools for poultry diseases are expected to be available in the future to enhance poultry disease prevention and reduce morbidity and mortality rates.
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金属纳米颗粒在家禽寄生虫病防治中的作用
用于治疗寄生虫病的纳米技术的发展仍处于起步阶段。然而,预计这一新领域可以为寄生虫病提供解决方案,并弥补缺乏预防它们的疫苗。它还可以为对现有治疗方法产生耐药性的寄生虫病提供新的治疗选择。纳米材料已被开发用于抗菌和抗癌治疗。然而,由于其物理化学性质的多样性,确定其抗寄生虫潜能是很重要的。在设计金属纳米粒子(MeNPs)和特殊的纳米系统时,如在药物外壳内封装的MeNPs,必须考虑几个关键的物理化学性质。形状、大小、表面电荷和表面活性剂控制类型是这些物理化学性质的一部分。除了与寄生虫细胞的靶分子相互作用外,壳分子也很重要。通过利用纳米技术和纳米材料开发用于诊断的抗寄生虫药物,有望在未来提供新的有效的家禽疾病治疗方法和诊断工具,以加强家禽疾病的预防并降低发病率和死亡率。
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