Tectorigenin suppresses the viability of gastric cancer cells in vivo and in vitro

IF 4.6 3区农林科学 Q1 FOOD SCIENCE & TECHNOLOGY Quality Assurance and Safety of Crops & Foods Pub Date : 2023-09-21 DOI:10.15586/qas.v15i3.1357

Wenchong Song, Weiwei Lv, Ning Bi, Guanglin Wang

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Abstract

Gastric cancer is currently the 4th most common malignant tumor with a poor prognosis in 2022. New and effective drugs are needed to combat this disease to treat advanced gastric cancer. Tectorigenin (Tec) has a series of pharmacological activities, such as anti-inflammatory and anticancer. However, the effect of Tec on the progression of gastric cancer is unclear. In this study, we investigated the role of Tec in regulating cell viability, cell cycle, and tumor growth of gastric cancer. To detect the role of Tec in the progression of gastric cancer in vitro and in mice, we performed several in vitro assays such as MTT, colony formation, wound closure, transwell, Immunoblot assays, and in vivo tumor growth assays. Our data confirmed that Tec restrained the viability of gastric cancer cells at concentrations of 100, 200, and 300 μM. It also denied the motility of gastric cancer cells. Tec treatment also induced the cell cycle arrest of gastric cancer cells. Mechanically, Tec could suppress the activation of the PI3K/Akt pathway and stop gastric cancer progression. We, therefore, thought Tec could serve as a drug for treating gastric cancer.

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鸢尾黄素在体内和体外均抑制胃癌细胞的活力

胃癌是目前第四大最常见的恶性肿瘤，2022年预后较差。需要新的和有效的药物来对抗这种疾病，以治疗晚期胃癌。鸢尾黄素(Tectorigenin, Tec)具有抗炎、抗癌等一系列药理作用。然而，Tec对胃癌进展的影响尚不清楚。在本研究中，我们研究了Tec在胃癌细胞活力、细胞周期和肿瘤生长中的作用。为了检测Tec在体外和小鼠胃癌进展中的作用，我们进行了几种体外试验，如MTT、菌落形成、伤口闭合、transwell、免疫印迹试验和体内肿瘤生长试验。我们的数据证实，Tec在100、200和300 μM浓度下抑制胃癌细胞的活力。同时也否定了胃癌细胞的运动性。Tec还能诱导胃癌细胞周期阻滞。机械上，Tec可以抑制PI3K/Akt通路的激活，阻止胃癌的进展。因此，我们认为Tec可以作为治疗胃癌的药物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Quality Assurance and Safety of Crops & Foods FOOD SCIENCE & TECHNOLOGY-

CiteScore

4.60

自引率

7.50%

发文量

审稿时长

1 months

期刊介绍： ''Quality Assurance and Safety of Crops & Foods'' is an international peer-reviewed journal publishing research and review papers associated with the quality and safety of food and food sources including cereals, grains, oilseeds, fruits, root crops and animal sources. It targets both primary materials and their conversion to human foods. There is a strong focus on the development and application of new analytical tools and their potential for quality assessment, assurance, control and safety. The scope includes issues of risk assessment, traceability, authenticity, food security and socio-economic impacts. Manuscripts presenting novel data and information that are likely to significantly contribute to scientific knowledge in areas of food quality and safety will be considered. ''Quality Assurance and Safety of Crops & Foods'' provides a forum for all those working in the specialist field of food quality and safety to report on the progress and outcomes of their research.