Comparison of clinical effectiveness of propofol auto co-induction and midazolam propofol co-induction using the priming principle among patients undergoing surgeries

Abstract

Introduction and Aim: Anaesthesia is a balance between adequate usage of anaesthetic drugs and the state of arousal of the patient. Inadequate dose of anaesthesia leads to increased incidence of awareness, while administration of generous drugs leads to complications such as hemodynamic instability and delayed recovery. The objective of the present study was to investigate the clinical effectiveness of propofol auto co-induction (PP) and midazolam propofol co-induction (PM) using the priming principle among patients undergoing surgeries.   Materials and Methods: A prospective, randomized and comparative study, recruited 80 patients who were admitted for elective surgeries was carried out after the approval from institutional ethics committee approval and the trial was registered with the clinical trial registry-India (CTRI). Patients were randomly divided into 2 groups: PP group, where patients received 0.4mg/kg of propofol and PM group, where patients received 0.05mg/kg of midazolam. This was followed by propofol induction (2 mg/kg)-10mg every 15 seconds until a BIS value of 45 was attained in both groups. The collected data was assessed for the normality using the Shapiro-Wilk test. A p-value greater than 0.05 (>0.05) was considered to check the normality. The Student’s t-test and Mann-Whitney U test was used to analyse parametric data and non-parametric data before and after the intervention, respectively.   Results: The results depicted a significantly reduced requirement of propofol (induction dose) in the PM group.   Conclusion: Pre-dosing with Midazolam significantly decreases the induction dose (propofol) requirement without affecting hemodynamic stability.