STUDY OF THE COMPOSITION OF AUXILARY SUBSTANCES WHICH ARE BEEN RESPONSIBLE FOR CONDUCT OF PROLONGED (MODIFIED) ACTION OF MEDICINES

Український журнал Клінічної та лабораторної медицини Pub Date : 2023-08-30 DOI:10.37864/2079-6676-2023-1-02

O.P. Gudzenko

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Abstract

Abstract. Introduction. Realization of action of medicines, including prolonged and modified, depends on composition of auxiliary substances in a medicinal form. Aim. Study of the composition of auxilary substances which are been responsible for conduct of prolonged (modified) action of medicines. Methods. Content analysis, system analysis, documental analysis. Results. Hydrophilic and inert components are prevailing among auxiliary substances of prolonged (modified) solid oral medicinal products (SOMP) presented in the State Register of Ukraine. Hydrophobic substances and substances, soluble at the defined values of рН, are being in less. Auxiliary substances of prolonged (modified) SOMP are presented by the derivatives of Cellulose, Ethyleneglycol, Acrylic acid, Pyrrolidone, Alginic acid, inorganics and wax-like components. Gummi and hydrocarbons are also being in the composition of prolonged SOMP. Conclusion. The nomenclature of auxiliary substances that are in the composition of prolonged (modified) SOMP has differences. Certain ratios of auxiliary components in the composition of SOMP are providing adjusting of time of release of medicinal substance from medicinal form.

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对辅助物质组成的研究，这些辅助物质负责药物延长(修饰)作用的进行

摘要& # x0D;介绍。药物作用的实现，包括延长和修改，取决于药物形式中辅助物质的组成。的目标。对药物延长(修饰)作用的辅助物质组成的研究。方法。内容分析、系统分析、文献分析。结果。亲水和惰性成分普遍存在于乌克兰国家登记册中提出的延长(改性)固体口服药品(SOMP)的辅助物质中。疏水物质和在规定值рН下可溶的物质正在减少。纤维素、乙二醇、丙烯酸、吡罗烷酮、褐藻酸、无机物和蜡样组分的衍生物是延长(改性)SOMP的辅助物质。Gummi和碳氢化合物也在长时间的SOMP中。结论。延长(改性)SOMP组成中的辅助物质的命名有差异。SOMP组成中一定比例的辅助成分可调节药物从药物形式释放的时间。

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Український журнал Клінічної та лабораторної медицини

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