{"title":"Investigation of a Static <i>k</i><sub>L</sub><i>a</i> Measurement Method Using an Optical Dissolved Oxygen Sensor with Fast Response Time","authors":"Eiji Nagamori, Takashi Sato","doi":"10.1252/kakoronbunshu.49.142","DOIUrl":null,"url":null,"abstract":"kLa値(酸素移動容量係数)は培養槽のスケールアップ指標として広く利用されており,その測定には従来から複数種の測定法が用いられてきた.中でも静的方法は菌体培養を必要せず,測定条件を柔軟に変更でき,繰り返し測定も容易であるため非常に簡便である.一方で従来のガルバニ電池式溶存酸素センサーでは応答遅れが顕著で,実培養で使用されるような高いkLa値の培養条件の評価が不可能であった.今回,応答速度が顕著に速い光学式溶存酸素センサーを用いることで300 h−1以上の高いkLaが静的方法により測定可能であることを明らかにした.さらに全くの同条件(同一容器,同一撹拌条件など)にて各種のkLa測定法との相関付けを行った.","PeriodicalId":17698,"journal":{"name":"Kagaku Kogaku Ronbunshu","volume":"96 1","pages":"0"},"PeriodicalIF":0.3000,"publicationDate":"2023-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Kagaku Kogaku Ronbunshu","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1252/kakoronbunshu.49.142","RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ENGINEERING, CHEMICAL","Score":null,"Total":0}