Investigation of Circulating Vaccine Derived Poliovirus Type 2 Outbreak, Sierra Leone, December 2020: Lessons from the First Three Cases

Gebru Gebrekrstos Negash, Sheriff Amara Alhaji, Elduma Adel Hussein
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Abstract

Circulating Vaccine Derived Poliovirus (cVDPV), is a genetic mutation of the Sabin virus. Sierra Leone reported its last case of wild polio virus in 2010. However, in December 2020, the national disease surveillance program was notified of three people with acute flaccid paralysis who had cVDPV2. We investigated to identify the source, determine the magnitude of the outbreak and risk factors.
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对2020年12月塞拉利昂流行疫苗衍生脊髓灰质炎病毒2型暴发的调查:来自前三个病例的教训
循环疫苗衍生脊髓灰质炎病毒(cVDPV)是沙宾病毒的一种基因突变。塞拉利昂在2010年报告了最后一例野生脊髓灰质炎病毒病例。然而,在2020年12月,国家疾病监测计划通知了三名患有急性弛缓性麻痹的人,他们患有cVDPV2。我们进行了调查,以确定来源,确定疫情的规模和危险因素。
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