Developing an Ovine Model of Impact Traumatic Brain Injury

IF 0.7 Q4 TRANSPORTATION SCIENCE & TECHNOLOGY SAE International Journal of Transportation Safety Pub Date : 2023-09-20 DOI:10.4271/09-11-02-0016
Charlie C Magarey, Ryan D Quarrington, Claire F Jones
{"title":"Developing an Ovine Model of Impact Traumatic Brain Injury","authors":"Charlie C Magarey, Ryan D Quarrington, Claire F Jones","doi":"10.4271/09-11-02-0016","DOIUrl":null,"url":null,"abstract":"<div>Traumatic brain injury is a leading cause of global death and disability. Clinically relevant large animal models are a vital tool for understanding the biomechanics of injury, providing validation data for computation models, and advancing clinical translation of laboratory findings. It is well-established that large angular accelerations of the head can cause TBI, but the effect of head impact on the extent and severity of brain pathology remains unclear. Clinically, most TBIs occur with direct head impact, as opposed to inertial injuries where the head is accelerated without direct impact. There are currently no active large animal models of impact TBI. Sheep may provide a valuable model for studying TBI biomechanics, with relatively large brains that are similar in structure to that of humans. The aim of this project is to develop an ovine model of impact TBI to study the relationships between impact mechanics and brain pathology. An elastic energy impact injury device has been developed to apply scalable head impacts to rapidly rotate the head without causing hard tissue damage. A motion constraint device has been developed to limit the head motion to a single plane of rotation. The apparatus has been tested using deceased animals to assess the controllability of impact velocities, the repeatability of head kinematics, and the dynamic response of the head to impact. Impact velocities are effectively controlled by modulating the elastic energy stored in the impact piston. The resulting head kinematics are somewhat variable, and are influenced by impact location, time-dependent postmortem tissue changes, and specimen head and neck physiology. Model development will continue, and in vivo testing will be conducted to assess the brain pathology following impacts of varying severity.</div>","PeriodicalId":42847,"journal":{"name":"SAE International Journal of Transportation Safety","volume":"38 1","pages":"0"},"PeriodicalIF":0.7000,"publicationDate":"2023-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"SAE International Journal of Transportation Safety","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4271/09-11-02-0016","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"TRANSPORTATION SCIENCE & TECHNOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Traumatic brain injury is a leading cause of global death and disability. Clinically relevant large animal models are a vital tool for understanding the biomechanics of injury, providing validation data for computation models, and advancing clinical translation of laboratory findings. It is well-established that large angular accelerations of the head can cause TBI, but the effect of head impact on the extent and severity of brain pathology remains unclear. Clinically, most TBIs occur with direct head impact, as opposed to inertial injuries where the head is accelerated without direct impact. There are currently no active large animal models of impact TBI. Sheep may provide a valuable model for studying TBI biomechanics, with relatively large brains that are similar in structure to that of humans. The aim of this project is to develop an ovine model of impact TBI to study the relationships between impact mechanics and brain pathology. An elastic energy impact injury device has been developed to apply scalable head impacts to rapidly rotate the head without causing hard tissue damage. A motion constraint device has been developed to limit the head motion to a single plane of rotation. The apparatus has been tested using deceased animals to assess the controllability of impact velocities, the repeatability of head kinematics, and the dynamic response of the head to impact. Impact velocities are effectively controlled by modulating the elastic energy stored in the impact piston. The resulting head kinematics are somewhat variable, and are influenced by impact location, time-dependent postmortem tissue changes, and specimen head and neck physiology. Model development will continue, and in vivo testing will be conducted to assess the brain pathology following impacts of varying severity.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
绵羊冲击创伤性脑损伤模型的建立
创伤性脑损伤是全球死亡和残疾的主要原因之一。临床相关的大型动物模型是理解损伤生物力学的重要工具,为计算模型提供验证数据,并推进实验室结果的临床转化。头部的大角加速度可以引起TBI,但头部撞击对脑部病理的程度和严重程度的影响尚不清楚。临床上,大多数脑损伤发生在头部直接撞击,而不是惯性损伤,即头部在没有直接撞击的情况下加速。目前还没有大型的撞击性脑损伤动物模型。绵羊可能为研究脑外伤生物力学提供一个有价值的模型,因为绵羊的大脑相对较大,结构与人类相似。本项目旨在建立绵羊撞击性脑损伤模型,研究撞击力学与脑病理学之间的关系。开发了一种弹性能量冲击损伤装置,用于应用可伸缩的头部冲击来快速旋转头部而不造成硬组织损伤。开发了一种运动约束装置,将头部运动限制在单一旋转平面内。该装置已使用死亡动物进行测试,以评估冲击速度的可控性,头部运动学的可重复性以及头部对冲击的动态响应。通过调节存储在冲击活塞中的弹性能量,有效地控制了冲击速度。由此产生的头部运动学在某种程度上是可变的,并受到撞击位置、时间依赖性死后组织变化和标本头部和颈部生理的影响。将继续开发模型,并进行体内试验,以评估不同严重程度影响后的脑病理。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
SAE International Journal of Transportation Safety
SAE International Journal of Transportation Safety TRANSPORTATION SCIENCE & TECHNOLOGY-
CiteScore
1.10
自引率
0.00%
发文量
21
期刊最新文献
Experimental Study on Ship Squat in Intermediate Channel Study of Vehicle-Based Metrics for Assessing the Severity of Side Impacts Distilled Routing Transformer for Driving Behavior Prediction Reviewers Thermal Modeling of the Electric Vehicle Fire Hazard Effects on Parking Building
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1