Prognostic Value of 18F-Fluorodeoxyglucose Uptake of Bone Marrow on PET/CT in Patients with Limited Disease Small Cell Lung Cancer

IF 0.3 4区医学 Q4 ONCOLOGY Uhod-Uluslararasi Hematoloji-Onkoloji Dergisi Pub Date : 2023-06-30 DOI:10.4999/uhod.236821

Merve Ayik Turk

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Abstract

Merve AYIK TURK1, Berna KOMURCUOGLU2, Ahmet YANARTAS3, Ozgur BATUM2, Yunus TURK4, Mehmet Ufuk YILMAZ5 1Izmir Bozyaka Training and Research Hospital, Department of Pulmonology, İzmir 2Dr. Suat Seren Chest Diseases and Surgery Training and Research Hospital, Department of Pulmonology, İzmir 3Dr. Suat Seren Chest Diseases and Surgery Training and Research Hospital, Department of Nuclear Medicine, İzmir 4Dr. Suat Seren Chest Diseases and Surgery Training and Research Hospital, Department of Thoracic Surgery, İzmir 5Medicana Health Groups, Department of Pulmonology, İzmir Keywords: Small cell lung cancer, Prognostic factors, Limited stage, Bone marrow FDG uptake Small cell lung cancer (SCLC) is a malignancy from the neuroendocrine tumor family, which has a poor prognosis and presents with metastases at the time of the diagnosis. The present study investigated the relationship between bone marrow fluorodeoxy-D-glucose (FDG) uptake and survival to evaluate prognosis in limited-stage SCLC. This single-center retrospective study examined a total of 220 patients diagnosed with limited-stage SCLC between January 2010 and June 2019. Bone marrow FDG uptake, serum inflammatory markers, and other factors used to determine the prognosis, as well as overall survival (OS) and progression-free survival (PFS), were recorded and retrospectively analyzed. Within physiological limits, bone marrow standardized uptake value (SUV) mean of > 1.95 was identified as a good prognostic factor for PFS (p= 0.03). The multivariate analysis of OS and PFS revealed that the Eastern Cooperative Oncology Group (ECOG) performance scale (p= 0.001) was a common independent prognostic factor. Stages of the disease, albumin levels and bone marrow-to-liver ratio (BLR) [one of the positron emission tomography/computed tomography (PET/CT) parameters] of < 0.8 were prognostic factors for OS. The bone marrow SUV mean was positively correlated with the primary tumor SUV max and SUV mean. The bone marrow SUV mean is a parameter that can be used to predict PFS in limited-stage SCLC. For OS, in turn, the BLR was identified as an independent factor.

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PET/CT对局限性小细胞肺癌患者骨髓18f -氟脱氧葡萄糖摄取的预后价值

Merve AYIK TURK1, Berna KOMURCUOGLU2, Ahmet YANARTAS3, Ozgur BATUM2, Yunus TURK4, Mehmet Ufuk YILMAZ5 1Izmir Bozyaka培训与研究医院肺病科，İzmir 2中山七胸外科培训研究医院，肺科，İzmir七科胸外科培训研究医院，核医学部，İzmir七胸外科培训与研究医院胸外科İzmir 5Medicana健康集团肺内科İzmir关键词:小细胞肺癌，预后因素，局限期，骨髓FDG摄取小细胞肺癌(Small cell lung cancer, SCLC)是一种神经内分泌肿瘤家族的恶性肿瘤，预后较差，诊断时伴有转移。本研究探讨骨髓氟脱氧- d-葡萄糖(FDG)摄取与生存的关系，以评估有限期SCLC的预后。这项单中心回顾性研究调查了2010年1月至2019年6月期间诊断为有限期SCLC的220例患者。记录并回顾性分析骨髓FDG摄取、血清炎症标志物和其他决定预后的因素，以及总生存期(OS)和无进展生存期(PFS)。在生理限度内，骨髓标准化摄取值(SUV)平均值为;1.95被认为是PFS的良好预后因素(p= 0.03)。OS和PFS的多变量分析显示，Eastern Cooperative Oncology Group (ECOG)绩效量表(p= 0.001)是常见的独立预后因素。疾病分期、白蛋白水平和骨髓肝比(BLR)[正电子发射断层扫描/计算机断层扫描(PET/CT)参数之一];0.8个是OS的预后因素。骨髓SUV均值与原发肿瘤SUV max、SUV均值呈正相关。骨髓SUV均值是预测有限期SCLC患者PFS的一个参数。对于OS，反过来，BLR被确定为一个独立的因素。

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来源期刊

Uhod-Uluslararasi Hematoloji-Onkoloji Dergisi ONCOLOGY-

CiteScore

1.60

自引率

16.70%

发文量

审稿时长

>12 weeks

期刊介绍： Target of Publication is the public representation of new scientific results of fundamental, problem-oriented, and search scientific investigations; analytical articles and reviews by actual scientific problems of coal mining industry, short reports in the field of coal mining industry, including the results of work of scientific meetings, conferences, summit’s and congresses in the field of mining. The basic purpose of the journal is the promotion of innovative activity in the coal mining industry by highlighting and discussing the results of basic and applied research, the experience in applying results of innovation for the development of the Russian coal mining. The most important tasks of the journal are: the generalization of scientific and practical achievements of specialists in the field of coal mining industry, specializing in the implementation of promising basic and applied research and development of priorities of high technologies; the scientific concept of the publication; the publication of the latest achievements in the field of innovation in coal mining industry. The journal lays special emphasis on methodical elaborations, analytical investigations in the sphere of coal mining. Targets of Journal are in publication of new results of scientific investigations performed by scientists, post-graduate students, and doctoral candidates performed by from higher schools, Russian Academy of Sciences, other scientific organizations of Russia, CIS countries, and foreign universities