Protective Effect of Pomegranate Juice Extract Against Antitubercular Drugs Induced Hepatic Fibrosis

Q4 Pharmacology, Toxicology and Pharmaceutics Toxicology International Pub Date : 2023-09-20 DOI:10.18311/ti/2023/v30i3/30923
J. Ramesh, Anilkumar Banothu, Kala Kumar Bharani, P. Shivakumar, M. Jeevanalatha, Y. Ravikumar
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Abstract

The current study aimed to know the therapeutic efficacy of Punica granatum (fruit juice extract) against anti-TB druginduced hepatic fibrosis in rats. 24 male Wistar albino rats were randomly divided into four groups, with six rats in each. INH at 27 mg/kg B.W., RIF at 54 mg/kg B.W., and PZA at 135 mg/kg B.W. were administered orally to Groups 2, 3 and 4 from days 1 to 28. Group 1 was maintained as normal control, and group 2 was a toxic control (administered anti-TB drugs, p/o). Groups 3 and 4 were administered (p/o) with Enalapril at 5mg/kg B.W. and Punica granatum (fresh juice extract) at 1 ml/rat, respectively, from day 1 to 28. Serum samples were collected on the 14th and 28th to assess various biochemical parameters, and liver samples were collected at the end of the experiment to analyze antioxidant parameters, TGF β1, and histopathological examination. The biochemical parameters showed significant (p<0.05) alterations in AST, ALT, GGT, antioxidant profile (TBARS GSH, GST, GPx and SOD), and expression of TGF β1 levels in group 2 along with collagen deposition and alterations in the histopathology when compared with group 1. There was a significant improvement in treatment groups 3 and 4 at different time intervals. These changes were reversed in groups 3 and 4, which were administered Enalapril and Punica granatum juice extract, respectively.
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石榴汁提取物对抗结核药物致肝纤维化的保护作用
本研究旨在了解石榴汁提取物对抗结核药物性肝纤维化大鼠的治疗作用。24只雄性Wistar白化大鼠随机分为4组,每组6只。第1 ~ 28天,第2、3、4组分别口服INH 27 mg/kg B.W、RIF 54 mg/kg B.W和PZA 135 mg/kg B.W。1组维持正常对照组,2组为毒性对照组(给予抗结核药物,p/o)。第3组和第4组分别给予依那普利(5mg/kg B.W.)和石榴汁提取物(1ml /只)(p/o),第1 ~ 28天。14日和28日采集血清样本评估各项生化参数,实验结束时采集肝脏样本分析抗氧化参数、TGF β1及组织病理学检查。与1组比较,2组的生化指标AST、ALT、GGT、抗氧化谱(TBARS、GSH、GST、GPx、SOD)、TGF β1表达水平、胶原沉积及组织病理学改变均显著(p<0.05)改变。治疗3组和治疗4组在不同时间间隔内均有显著改善。这些变化在3组和4组逆转,分别给予依那普利和石榴汁提取物。
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来源期刊
Toxicology International
Toxicology International Environmental Science-Health, Toxicology and Mutagenesis
CiteScore
0.60
自引率
0.00%
发文量
23
期刊介绍: Toxicology International is a peer-reviewed International Research Journal published bi-annually by the Society of Toxicology, India. The Journal is concerned with various disciplines of Toxicology including man, animals, plants and environment and publishes research, review and general articles besides opinions, comments, news-highlights and letters to editor.
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