[Application of the 6-day subrenal capsule assay for sensitivity testing of antineoplastic chemotherapy in oral mucosa carcinoma].

Abstract

Tissues from squamous cell carcinomas of the oral cavity of 20 patients were transplanted beneath the capsule of the kidney of normal immunocompetent mice (SRCA). The xenografts of all tumors of the control group of animals without chemotherapy show an increasing tumor mass following a 6-day-test-period using a method of measurement given by Bogden et al. (1978). There were different changes of tumor diameters following the application of various antineoplastic drugs. Tumor proliferation however is not reason for these changes. There are reactions of graft's rejection which play an important part in the measured data. The only interpretation of the diameters of the xenografts using the 6-day-SRCA in normal immunocompetent mice cannot be recommended as a criterion in this predictive test.