Tissue distribution and excretion of iotrolan after intravenous and suboccipital injections in animals.

H J Weinmann, P Scholz, W Mützel
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Abstract

The fate of iotrolan in the body is determined by its physicochemical characteristics and biologic inertness. Iotrolan is distributed in the extracellular space after intravenous or intracisternal injections. No absorption occurred after oral administration. Iotrolan is eliminated almost exclusively by renal excretion in an unmetabolized form. The results found are very similar to those published for other x-ray contrast agents used in uroangiography.

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静脉注射和枕下注射后iotrolan在动物体内的组织分布和排泄。
碘曲兰在体内的命运是由它的物理化学特性和生物惰性决定的。静脉注射或腹腔注射后,碘曲兰分布于细胞外间隙。口服后无吸收。Iotrolan几乎完全通过肾脏排泄以非代谢形式排出。发现的结果与发表的用于泌尿血管造影的其他x线造影剂的结果非常相似。
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