[Experimental model of ischemic injury of the spinal cord after temporary occlusion of the thoracic artery in the dog].

I Sulla, M Santa, J Marsala
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Abstract

An experimental model for the ischemic damage of the spinal marrow is described by occlusion of the descending thoracic aorta at a level with the 5th or 6th thoracic vertebrae during 30 min. 17 dogs were operated in general anesthesia. The thoracic aorta was clamped by a Pean's clamp in the 1st group (11 animals). One dog was not paralysed, another dog died after thrombosis of the aorta in the locality of clamping. The occlusion was carried out by means of a tourniquet in a 2nd group (6 animals) and pH, blood gas values, and blood pressure in the axillary artery or the common carotid artery were measured. An increase of the blood pressure above the initial value was prevented by slow infusion of nitroprusside. The oxygen pressure in the spinal marrow tissue was measured continuously simultaneously. All these animals survived the operation and a complete damage of the spinal marrow occurred.

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[犬胸动脉暂时性闭塞后脊髓缺血性损伤的实验模型]。
通过在30分钟内阻断胸降主动脉至第5或第6胸椎的水平来描述脊髓缺血性损伤的实验模型。17只狗在全身麻醉下进行手术。第一组(11只)采用Pean钳夹持胸主动脉。1只犬未瘫痪,1只犬夹持部位主动脉血栓形成死亡。第二组(6只)采用止血带闭塞,测定腋动脉或颈总动脉pH值、血气值和血压。缓慢输注硝普钠可防止血压高于初始值。同时连续测定脊髓组织内氧压。所有这些动物都在手术中幸存下来,脊髓完全受损。
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