Issue Information

Abstract

Cover: In Döpper et al. (http://doi.org/10.1002/cpsc.120), the image shows immunostaining for early retinal markers and all retinal cell types. At d35, the outer layer stains positive for the early eye field marker RX. Moreover, in the outer part, retinal progenitor cells (VSX2), and in the inner part, ganglion cells are present (BRN3). CRX, a marker for retinal progenitors and immature photoreceptors, is present at d35, and a shift to the outer layer can be detected at d61. Horizontal cells (PROX1) and amacrine cells (AP2α) are present in the inner nuclear layer (d61, d126). Cone photoreceptors (RXRγ, ARR3; d96, d126, d152) and rod photoreceptors (NRL; d152) are present in the outer nuclear layer. Bipolar cells (PKCα) and Müller glia cells (VIM) are present in the inner nuclear layer (d152). A schematic overview of the retina with the seven different cell types organized in specific layers is given. Secondary antibodies were labeled in green (AlexaFluor 488), and nuclei were stained with DAPI (blue). Scale bar: 50 µm.