Investigating a Causal Relationship Between Diabetes Mellitus and Oropharyngeal Cancer: A Mendelian Randomization Study.

IF 0.9 4区医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Community dental health Pub Date : 2023-11-30 DOI:10.1922/CDH_00025Huang09

Y Huang, L Jiang, J Liu, Y Xu, F Mo, J Su, R Tao

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引用次数: 0

Abstract

Objective: Previous observational studies reported an association of diabetes mellitus (DM) with oropharyngeal cancer (OPC), however, the potential causality of the association between them remains unclear.

Methods: To explore this causal relationship in individuals of European descent, a two-sample Mendelian randomization (MR) study was conducted. A genome-wide association study (GWAS) of DM was used to represent the exposure factor (T1DM: n = 24,840; T2DM: n = 215,654), and GWAS of OPC represented the outcome (n = 3,448).

Results: Forty-one single nucleotide polymorphisms (SNPs) related to T1DM and fifty-four SNPs related to T2DM were identified as effective instrumental variables (IVs) in the two-sample MR analyses. In IVW estimates, neither T1DM nor T2DM significantly contributed to an increased risk of OPC [T1DM: OR 1.0322 (95% CI 0.9718, 1.0963), P = 0.3033; T2DM: OR 0.9998 (95% CI 0.9995, 1.0002), P = 0.2858]. Four other regression models produced similar results. MR-Egger regression results [Cochran's Q statistic was 47.1544 (P = 0.1466) in T1DM, and 35.5084 (P = 0.9512) in T2DM] suggested no horizontal pleiotropy between IVs and outcomes.

Conclusion: Our findings suggest little evidence to support the genetic role of diabetes mellitus in OPC development in the European population.

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调查糖尿病和口咽癌之间的因果关系:一项孟德尔随机研究。

目的:以往的观察性研究报道了糖尿病(DM)与口咽癌(OPC)的关联，然而，两者之间潜在的因果关系尚不清楚。方法:为了在欧洲血统个体中探索这种因果关系，进行了一项双样本孟德尔随机化(MR)研究。DM的全基因组关联研究(GWAS)被用来表示暴露因素(T1DM: n = 24840;T2DM: n = 215,654)， OPC的GWAS代表结果(n = 3,448)。结果:在两样本MR分析中，41个与T1DM相关的单核苷酸多态性(snp)和54个与T2DM相关的snp被确定为有效的工具变量(IVs)。在IVW估计中，T1DM和T2DM均未显著增加OPC的风险[T1DM: OR 1.0322 (95% CI 0.9718, 1.0963)， P = 0.3033;T2dm:或0.9998 (95% ci 0.9995, 1.0002)， p = 0.2858]。另外四个回归模型也得出了类似的结果。MR-Egger回归结果[T1DM组Cochran's Q统计值为47.1544 (P = 0.1466)， T2DM组为35.5084 (P = 0.9512)]提示IVs与预后之间无水平多效性。结论:我们的研究结果表明，在欧洲人群中，几乎没有证据支持糖尿病在OPC发展中的遗传作用。

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来源期刊

Community dental health 医学-牙科与口腔外科

CiteScore

2.20

自引率

11.80%

发文量

审稿时长

6-12 weeks

期刊介绍： The journal is concerned with dental public health and related subjects. Dental public health is the science and the art of preventing oral disease, promoting oral health, and improving the quality of life through the organised efforts of society. The discipline covers a wide range and includes such topics as: -oral epidemiology- oral health services research- preventive dentistry - especially in relation to communities- oral health education and promotion- clinical research - with particular emphasis on the care of special groups- behavioural sciences related to dentistry- decision theory- quality of life- risk analysis- ethics and oral health economics- quality assessment. The journal publishes scientific articles on the relevant fields, review articles, discussion papers, news items, and editorials. It is of interest to dentists working in dental public health and to other professionals concerned with disease prevention, health service planning, and health promotion throughout the world. In the case of epidemiology of oral diseases the Journal prioritises national studies unless local studies have major methodological innovations or information of particular interest.