Association of ATG16L1 and ATG5 gene polymorphisms with susceptibility to hepatitis B virus infection and progression to HCC in central China

IF 1.9 4区 医学 Q4 IMMUNOLOGY Microbiology and Immunology Pub Date : 2023-11-22 DOI:10.1111/1348-0421.13104
Qiaoyu Wu, Yaoling Ouyang
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Abstract

Hepatitis B virus (HBV) infection is a severe public health problem worldwide. The relationship between polymorphisms of autophagy-related 16-like 1 gene (ATG16L1) and autophagy-related gene 5 (ATG5) with susceptibility to the stage of HBV infection has been reported in different populations. Nevertheless, this association is not seen in the population of central China. This study recruited 452 participants, including 246 HBV-infected patients (139 chronically infected HBV without hepatocellular carcinoma [HCC] and 107 HBV-related HCC patients) and 206 healthy controls. Genotyping of ATG16L1 rs2241880 and ATG5 rs688810 were performed using Sanger sequencing and polymerase chain reaction-restriction fragment length polymorphism, respectively. Our results indicated that the G allele of ATG16L1 rs2241880 was more frequent in healthy controls than in patients with chronicHBV infection. After adjusting for age and sex, an association between the ATG16L1 rs2241880 polymorphism and HBV infection was significant under the dominant and allele models (p = 0.009 and 0.003, respectively). However, no association between the ATG5 polymorphisms and HBV infection was observed. We also did not find a significant association between ATG16L1 and ATG5 polymorphisms and the progression of HBV-related HCC. Therefore, the genetic polymorphism of ATG16L1 rs2241880 may be associated with susceptibility to HBV infection in the population of central China.

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中国中部地区ATG16L1和ATG5基因多态性与乙型肝炎病毒感染易感性和HCC进展的关系
乙型肝炎病毒(HBV)感染是世界范围内严重的公共卫生问题。自噬相关16-样1基因(ATG16L1)和自噬相关基因5 (ATG5)多态性与HBV感染阶段易感性的关系在不同人群中已有报道。然而,这种关联在中国中部人群中未见。该研究招募了452名参与者,包括246名HBV感染患者(139名慢性HBV感染无肝细胞癌[HCC]和107名HBV相关HCC患者)和206名健康对照。ATG16L1 rs2241880和ATG5 rs688810分别采用Sanger测序和聚合酶链反应-限制性片段长度多态性进行基因分型。我们的研究结果表明,ATG16L1 rs2241880的G等位基因在健康对照中比在慢性乙型肝炎感染患者中更常见。在调整年龄和性别后,在显性和等位基因模型下,ATG16L1 rs2241880多态性与HBV感染之间存在显著关联(p分别= 0.009和0.003)。然而,ATG5多态性与HBV感染之间没有关联。我们也没有发现ATG16L1和ATG5多态性与hbv相关HCC进展之间的显著关联。因此,ATG16L1 rs2241880基因多态性可能与中国中部人群对HBV感染的易感性有关。
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来源期刊
Microbiology and Immunology
Microbiology and Immunology 医学-免疫学
CiteScore
5.20
自引率
3.80%
发文量
78
审稿时长
1 months
期刊介绍: Microbiology and Immunology is published in association with Japanese Society for Bacteriology, Japanese Society for Virology, and Japanese Society for Host Defense Research. It is peer-reviewed publication that provides insight into the study of microbes and the host immune, biological and physiological responses. Fields covered by Microbiology and Immunology include:Bacteriology|Virology|Immunology|pathogenic infections in human, animals and plants|pathogenicity and virulence factors such as microbial toxins and cell-surface components|factors involved in host defense, inflammation, development of vaccines|antimicrobial agents and drug resistance of microbes|genomics and proteomics.
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